Depressão na doença de Parkinson prodrômica: uma revisão sistemática
DOI:
https://doi.org/10.25118/2763-9037.2025.v15.1507Palavras-chave:
Depressão, doença de Parkinson, sintomas depressivosResumo
Introdução: A doença de Parkinson (DP) é marcada não apenas por sintomas motores, mas também por sintomas não motores, como distúrbio do sono REM, constipação intestinal, anosmia, disautonomia, depressão, ansiedade, comprometimento cognitivo e outros. É possível que esses sintomas antecedam a bradicinesia, formando uma condição denominada DP Prodrômica (DPP). A identificação da DPP permite a otimização do tratamento e do cuidado. A identificação desses pacientes com DPP permanece um desafio, visto que muitos dos sintomas listados são prevalentes na população idosa. A depressão é destacada como um sintoma prodrômico, mas identificar pacientes com sintomas depressivos que fazem parte da DPP é uma tarefa desafiadora. Objetivos: realizar uma revisão sistemática da literatura, visando identificar avanços e atualizações em relação à depressão na DPP, permitindo a identificação de pacientes com depressão que fazem parte do grupo de pacientes com DPP. Métodos: revisão sistemática da literatura, seguindo as diretrizes do protocolo PRISMA 2020; busca pelos descritores depressão, sintomas depressivos e doença de parkinson prodrômica na Plataforma Pubmed. Foram encontradas 25 publicações; Ao final, restaram 9 artigos para inclusão na revisão. Resultados: observou-se valor preditivo na combinação de distúrbio do sono REM e depressão para o desenvolvimento de TP; a presença de dois ou mais sintomas prodrômicos combinados representou um fator preditivo para TP; a hospitalização por depressão previu o risco de desenvolver TP. Conclusão: a combinação de depressão e outros sintomas prodrômicos prediz o TP, bem como a gravidade e a refratariedade do quadro depressivo. Os sintomas prodrômicos permanecem um desafio, mas podem ser ativamente investigados.
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