Efeito da atividade física e do exercício sobre o comprometimento cognitivo leve e a demência: uma revisão da literatura
DOI:
https://doi.org/10.25118/2763-9037.2024.v14.1075Palavras-chave:
doença de Alzheimer, prevenção de doenças, terapêutica, Alzheimer, demência, exercício físico, atividade física, prevenção, depressão resistente ao tratamentoResumo
Introdução: O aumento da prevalência global de distúrbios cognitivos, incluindo o comprometimento cognitivo leve (CCL) e a demência, exige intervenções eficazes. Esta revisão da literatura examina o impacto da atividade física e do exercício em indivíduos com CCL e demência. Objetivo e método: Foi realizada uma pesquisa abrangente da literatura e uma revisão narrativa para explorar a influência da atividade física na saúde cognitiva, enfatizando mecanismos como o aumento do fluxo sanguíneo cerebral e fatores neurotróficos. Resultados e discussão: Os estudos revisados sugerem que a atividade física regular pode afetar positivamente a função cognitiva e pode servir como um componente valioso em estratégias abrangentes para a prevenção e o gerenciamento de distúrbios cognitivos. As evidências destacam o papel potencial da atividade física na redução do risco de demência e na diminuição do declínio cognitivo. Conclusão: A integração da atividade física e do exercício nas rotinas diárias e nas estratégias de saúde é fundamental para enfrentar o desafio crescente dos distúrbios cognitivos, potencialmente melhorando a qualidade de vida dos indivíduos afetados e reduzindo a carga social associada a eles.
Downloads
Métricas
Referências
Ferretti CEL, Nitrini R, Brucki SMD. Indirect cost with dementia: a Brazilian study. Dement Neuropsychol. 2015;9(1):42-50. https://doi.org/10.1590/s1980-57642015dn91000007 PMID:29213940 - PMCID:PMC5618990 DOI: https://doi.org/10.1590/S1980-57642015DN91000007
Vargas EA, Gallardo AMR, Manrrique GG, Murcia-Paredes LM, Riano MCA; Grupo DNEUROPSY. Prevalence of dementia in Colombian populations. Dement Neuropsychol. 2014;8(4):323-9. https://doi.org/10.1590/s1980-57642014dn84000004 PMID:29213921 - PMCID:PMC5619179 DOI: https://doi.org/10.1590/S1980-57642014DN84000004
Elahi FM, Miller BL. A clinicopathological approach to the diagnosis of dementia. Nat Rev Neurol. 2017;13(8):457-76. https://doi.org/10.1038/nrneurol.2017.96 PMID:28708131 PMCID:PMC5771416
Lopez OL, Kuller LH. Epidemiology of aging and associated cognitive disorders: prevalence and incidence of Alzheimer's disease and other dementias. Handb Clin Neurol. 2019;167:139-48. https://doi.org/10.1016/b978-0-12-804766-8.00009-1 PMID:31753130 DOI: https://doi.org/10.1016/B978-0-12-804766-8.00009-1
Elahi FM, Miller BL. A clinicopathological approach to the diagnosis of dementia. Nat Rev Neurol. 2017;13(8):457-76. https://doi.org/10.1038/nrneurol.2017.96 PMID:28708131 PMCID:PMC5771416 DOI: https://doi.org/10.1038/nrneurol.2017.96
Soria Lopez JA, González HM, Léger GC. Alzheimer's disease. Handb Clin Neurol. 2019;167:231-55. https://doi.org/10.1016/b978-0-12-804766-8.00013-3 PMID:31753135 DOI: https://doi.org/10.1016/B978-0-12-804766-8.00013-3
Larson EB. Evaluation of cognitive impairment and dementia. Alphen aan den Rijn: UpToDate; 2019 https://www.uptodate.com/contents/evaluation-of-cognitive-impairment-and-dementia
Raz L, Knoefel J, Bhaskar K. The neuropathology and cerebrovascular mechanisms of dementia. J Cereb Blood Flow Metab. 2016;36(1):172-86. https://doi.org/10.1038/jcbfm.2015.164 PMID:26174330 PMCID:PMC4758551 DOI: https://doi.org/10.1038/jcbfm.2015.164
Hasin DS, O'Brien CP, Auriacombe M, Borges G, Bucholz K, Budney A, Compton WM, Crowley T, Ling W, Petry NM, Schuckit M, Grant BF. DSM-5 criteria for substance use disorders: recommendations and rationale. Am J Psychiatry. 2013;170(8):834-51. https://doi.org/10.1176/appi.ajp.2013.12060782 PMID:23903334 - PMCID:PMC3767415 DOI: https://doi.org/10.1176/appi.ajp.2013.12060782
Jongsiriyanyong S, Limpawattana P. Mild cognitive impairment in clinical practice: a review article. Am J Alzheimers Dis Other Demen. 2018;33(8):500-7. https://doi.org/10.1177/1533317518791401 PMID:30068225 - PMCID:PMC10852498
Brucki SMD. Epidemiology of mild cognitive impairment in Brazil. Dement Neuropsychol. 2013;7(4):363-6. https://doi.org/10.1590/s1980-57642013dn74000002 PMID:29213859 - PMCID:PMC5619496 DOI: https://doi.org/10.1590/S1980-57642013DN74000002
Langa KM, Levine DA. The diagnosis and management of mild cognitive impairment: a clinical review. JAMA. 2014;312(23):2551-61. https://doi.org/10.1001/jama.2014.13806 PMID:25514304 PMCID:PMC4269302 DOI: https://doi.org/10.1001/jama.2014.13806
Dominguez LJ, Veronese N, Vernuccio L, Catanese G, Inzerillo F, Salemi G, Barbagallo M. Nutrition, Physical activity, and other lifestyle factors in the prevention of cognitive decline and dementia. Nutrients. 2021;13(11):4080. https://doi.org/10.3390/nu13114080 PMID:34836334 - PMCID:PMC8624903 DOI: https://doi.org/10.3390/nu13114080
Livingston G, Sommerlad A, Orgeta V, Costafreda SG, Huntley J, Ames D, Ballard C, Banerjee S, Burns A, Cohen-Mansfield J, Cooper C, Fox N, Gitlin LN, Howard R, Kales HC, Larson EB, Ritchie K, Rockwood K, Sampson EL, Samus Q, Schneider LS, Selbæk G, Teri L, Mukadam N. Dementia prevention, intervention, and care. Lancet. 2017;390(10113):2673-734. https://doi.org/10.1016/s0140-6736(17)31363-6 PMID:28735855 DOI: https://doi.org/10.1016/S0140-6736(17)31363-6
Brett L, Traynor V, Stapley P. Effects of physical exercise on health and well-being of individuals living with a dementia in nursing homes: a systematic review. J Am Med Dir Assoc. 2016;17(2):104-16. https://doi.org/10.1016/j.jamda.2015.08.016 PMID:26432622 DOI: https://doi.org/10.1016/j.jamda.2015.08.016
Liang JH, Lu L, Li JY, Qu XY, Li J, Qian S, Wang YQ, Jia RX, Wang CS, Xu Y. Contributions of modifiable risk factors to dementia incidence: a bayesian network analysis. J Am Med Dir Assoc. 2020;21(11):1592-9.e13. https://doi.org/10.1016/j.jamda.2020.04.006 PMID:32563753 DOI: https://doi.org/10.1016/j.jamda.2020.04.006
Colcombe SJ, Erickson KI, Scalf PE, Kim JS, Prakash R, McAuley E, Elavsky S, Marquez DX, Hu L, Kramer AF. Aerobic exercise training increases brain volume in aging humans. J Gerontol A Biol Sci Med Sci. 2006;61(11):1166-70. https://doi.org/10.1093/gerona/61.11.1166 PMID:17167157 DOI: https://doi.org/10.1093/gerona/61.11.1166
Fabel K, Wolf SA, Ehninger D, Babu H, Leal-Galicia P, Kempermann G. Additive effects of physical exercise and environmental enrichment on adult hippocampal neurogenesis in mice. Front Neurosci. 2009;3:50. https://doi.org/10.3389/neuro.22.002.2009 PMID:20582277 PMCID:PMC2858601 DOI: https://doi.org/10.3389/neuro.22.002.2009
Law LL, Barnett F, Yau MK, Gray MA. Effects of combined cognitive and exercise interventions on cognition in older adults with and without cognitive impairment: a systematic review. Ageing Res Rev. 2014;15:61-75. https://doi.org/10.1016/j.arr.2014.02.008 PMID:24632497 DOI: https://doi.org/10.1016/j.arr.2014.02.008
Demurtas J, Schoene D, Torbahn G, Marengoni A, Grande G, Zou L, Petrovic M, Maggi S, Cesari M, Lamb S, Soysal P, Kemmler W, Sieber C, Mueller C, Shenkin SD, Schwingshackl L, Smith L, Veronese N; European Society of Geriatric Medicine Special Interest Group in Systematic Reviews and Meta-Analyses, Frailty, Sarcopenia, and Dementia. Physical activity and exercise in mild cognitive impairment and dementia: an umbrella review of intervention and observational studies. J Am Med Dir Assoc. 2020;21(10):1415-22.e6. https://doi.org/10.1016/j.jamda.2020.08.031 PMID:32981668 DOI: https://doi.org/10.1016/j.jamda.2020.08.031
Lu Z, Harris TB, Shiroma EJ, Leung J, Kwok T. Patterns of physical activity and sedentary behavior for older adults with Alzheimer's disease, mild cognitive impairment, and cognitively normal in Hong Kong. J Alzheimers Dis. 2018;66(4):1453-62. https://doi.org/10.3233/jad-180805 PMID:30412502 PMCID:PMC6301091 DOI: https://doi.org/10.3233/JAD-180805
Wagner M, Jurcoane A, Volz S, Magerkurth J, Zanella FE, Neumann-Haefelin T, Deichmann R, Singer OC, Hattingen E. Age-related changes of cerebral autoregulation: new insights with quantitative T2'-mapping and pulsed arterial spin-labeling MR imaging. AJNR Am J Neuroradiol. 2012;33(11):2081-7. https://doi.org/10.3174/ajnr.a3138 PMID:22700750 PMCID:PMC7965581 DOI: https://doi.org/10.3174/ajnr.A3138
Scholl M, Lockhart SN, Schonhaut DR, O'Neil JP, Janabi M, Ossenkoppele R, Baker SL, Vogel JW, Faria J, Schwimmer HD, Rabinovici GD, Jagust WJ. PET imaging of tau deposition in the aging human brain. Neuron. 2016;89(5):971-82. https://doi.org/10.1016/j.neuron.2016.01.028 PMID:26938442 PMCID:PMC4779187 DOI: https://doi.org/10.1016/j.neuron.2016.01.028
Corrada MM, Berlau DJ, Kawas CH. A population-based clinicopathological study in the oldest-old: the 90+ study. Curr Alzheimer Res. 2012;9(6):709-17. https://doi.org/10.2174/156720512801322537 PMID:22471863 PMCID:PMC3409303 DOI: https://doi.org/10.2174/156720512801322537
Hamby ME, Coppola G, Ao Y, Geschwind DH, Khakh BS, Sofroniew MV. Inflammatory mediators alter the astrocyte transcriptome and calcium signaling elicited by multiple G-protein-coupled receptors. J Neurosci. 2012;32(42):14489-510. https://doi.org/10.1523/jneurosci.1256-12.2012 PMID:23077035 PMCID:PMC3518872 DOI: https://doi.org/10.1523/JNEUROSCI.1256-12.2012
Lim D, Iyer A, Ronco V, Grolla AA, Canonico PL, Aronica E, Genazzani AA. Amyloid beta deregulates astroglial mGluR5-mediated calcium signaling via calcineurin and Nf-kB. Glia. 2013;61(7):1134-45. https://doi.org/10.1002/glia.22502 PMID:23616440 DOI: https://doi.org/10.1002/glia.22502
Orr AG, Hsiao EC, Wang MM, Ho K, Kim DH, Wang X, Guo W, Kang J, Yu GQ, Adame A, Devidze N, Dubal DB, Masliah E, Conklin BR, Mucke L. Astrocytic adenosine receptor A2A and Gs-coupled signaling regulate memory. Nat Neurosci. 2015;18(3):423-34. https://doi.org/10.1038/nn.3930 PMID:25622143 PMCID:PMC4340760 DOI: https://doi.org/10.1038/nn.3930
Hardt O, Nader K, Nadel L. Decay happens: the role of active forgetting in memory. Trends Cogn Sci. 2013;17(3):111-20. https://doi.org/10.1016/j.tics.2013.01.001 PMID:23369831 DOI: https://doi.org/10.1016/j.tics.2013.01.001
Santello M, Toni N, Volterra A. Astrocyte function from information processing to cognition and cognitive impairment. Nat Neurosci. 2019;22(2):154-66. https://doi.org/10.1038/s41593-018-0325-8 PMID:30664773 DOI: https://doi.org/10.1038/s41593-018-0325-8
Herbet G, Duffau H. Revisiting the functional anatomy of the human brain: toward a meta-networking theory of cerebral functions. Physiol Rev. 2020;100(3):1181-228. https://doi.org/10.1152/physrev.00033.2019 PMID:32078778 DOI: https://doi.org/10.1152/physrev.00033.2019
Jongsiriyanyong S, Limpawattana P. Mild cognitive impairment in clinical practice: a review article. Am J Alzheimers Dis Other Demen. 2018;33(8):500-7. https://doi.org/10.1177/1533317518791401 PMID:30068225 - PMCID:PMC10852498 DOI: https://doi.org/10.1177/1533317518791401
Oschwald J, Guye S, Liem F, Rast P, Willis S, Rocke C, Jancke L, Martin M, Mérillat S. Brain structure and cognitive ability in healthy aging: a review on longitudinal correlated change. Rev Neurosci. 2019;31(1):1-57. https://doi.org/10.1515/revneuro-2018-0096 PMID:31194693 - PMCID:PMC8572130 DOI: https://doi.org/10.1515/revneuro-2018-0096
Weil RS, Costantini AA, Schrag AE. Mild cognitive impairment in parkinson's disease-what is it? Curr Neurol Neurosci Rep. 2018;18(4):17. https://doi.org/10.1007/s11910-018-0823-9 PMID:29525906 - PMCID:PMC5845587 DOI: https://doi.org/10.1007/s11910-018-0823-9
Sui SX, Williams LJ, Holloway-Kew KL, Hyde NK, Pasco JA. Skeletal muscle health and cognitive function: a narrative review. Int J Mol Sci. 2020;22(1):255. https://doi.org/10.3390/ijms22010255 PMID:33383820 PMCID:PMC7795998 DOI: https://doi.org/10.3390/ijms22010255
Kouloutbani K, Venetsanou F, Markati A, Karteroliotis KE, Politis A. The effectiveness of physical exercise interventions in the management of neuropsychiatric symptoms in dementia patients: a systematic review. Int Psychogeriatr. 2022;34(2):177-90. https://doi.org/10.1017/s1041610221000193 PMID:33818342 DOI: https://doi.org/10.1017/S1041610221000193
Nuzum H, Stickel A, Corona M, Zeller M, Melrose RJ, Wilkins SS. Potential benefits of physical activity in MCI and dementia. Behav Neurol. 2020;2020:7807856. https://doi.org/10.1155/2020/7807856 PMID:32104516 PMCID:PMC7037481 DOI: https://doi.org/10.1155/2020/7807856
Gholamnezhad Z, Boskabady MH, Jahangiri Z. Exercise and dementia. Adv Exp Med Biol. 2020;1228:303-15. https://doi.org/10.1007/978-981-15-1792-1_20 PMID:32342466 DOI: https://doi.org/10.1007/978-981-15-1792-1_20
Jeong MK, Park KW, Ryu JK, Kim GM, Jung HH, Park H. Multi-component intervention program on habitual physical activity parameters and cognitive function in patients with mild cognitive impairment: a randomized controlled trial. Int J Environ Res Public Health. 2021;18(12):6240. https://doi.org/10.3390/ijerph18126240 PMID:34207701 - PMCID:PMC8296099 DOI: https://doi.org/10.3390/ijerph18126240
Erickson KI, Donofry SD, Sewell KR, Brown BM, Stillman CM. Cognitive aging and the promise of physical activity. Annu Rev Clin Psychol. 2022;18:417-42. https://doi.org/10.1146/annurev-clinpsy-072720-014213 PMID:35044793 DOI: https://doi.org/10.1146/annurev-clinpsy-072720-014213
Wang S, Liu HY, Cheng YC, Su CH. Exercise dosage in reducing the risk of dementia development: mode, duration, and intensity-a narrative review. Int J Environ Res Public Health. 2021;18(24):13331. https://doi.org/10.3390/ijerph182413331 PMID:34948942 - PMCID:PMC8703896 DOI: https://doi.org/10.3390/ijerph182413331
Yu F, Lin FV, Salisbury DL, Shah KN, Chow L, Vock D, Nelson NW, Porsteinsson AP, Jack C Jr. Efficacy and mechanisms of combined aerobic exercise and cognitive training in mild cognitive impairment: study protocol of the ACT trial. Trials. 2018;19(1):700. https://doi.org/10.1186/s13063-018-3054-0 PMID:30577848 PMCID:PMC6303946 DOI: https://doi.org/10.1186/s13063-018-3054-0
Antunes HKM, Santos RF, Cassilhas R, Santos RVT, Bueno OFA, Mello MT. Exercício físico e função cognitiva: uma revisão. Rev Bras Med Esporte. 2006;12(2):108-14. https://doi.org/10.1590/S1517-86922006000200011 DOI: https://doi.org/10.1590/S1517-86922006000200011
García-Hermoso A, Ramírez-Vélez R, Celis-Morales CA, Olloquequi J, Izquierdo M. Can physical activity attenuate the negative association between sitting time and cognitive function among older adults? A mediation analysis. Exp Gerontol. 2018;106:173-7. https://doi.org/10.1016/j.exger.2018.03.002 PMID:29549034 DOI: https://doi.org/10.1016/j.exger.2018.03.002
O'Callaghan C, Lewis SJG. Cognition in Parkinson's disease. Int Rev Neurobiol. 2017;133:557-83. https://doi.org/10.1016/bs.irn.2017.05.002 PMID:28802933 DOI: https://doi.org/10.1016/bs.irn.2017.05.002
Chow ZS, Moreland AT, Macpherson H, Teo WP. The central mechanisms of resistance training and its effects on cognitive function. Sports Med. 2021;51(12):2483-506. https://doi.org/10.1007/s40279-021-01535-5 PMID:34417978 DOI: https://doi.org/10.1007/s40279-021-01535-5
Law CK, Lam FM, Chung RC, Pang MY. Physical exercise attenuates cognitive decline and reduces behavioural problems in people with mild cognitive impairment and dementia: a systematic review. J Physiother. 2020;66(1):9-18. https://doi.org/10.1016/j.jphys.2019.11.014 PMID:31843427 DOI: https://doi.org/10.1016/j.jphys.2019.11.014
Giroud N, Keller M, Meyer M. Interacting effects of frontal lobe neuroanatomy and working memory capacity to older listeners' speech recognition in noise. Neuropsychologia. 2021;158:107892. https://doi.org/10.1016/j.neuropsychologia.2021.107892 PMID:34019869 DOI: https://doi.org/10.1016/j.neuropsychologia.2021.107892
d'Arbeloff T. Cardiovascular fitness and structural brain integrity: an update on current evidence. Geroscience. 2020;42(5):1285-306. https://doi.org/10.1007/s11357-020-00244-7 PMID:32767221 PMCID:PMC7525918 DOI: https://doi.org/10.1007/s11357-020-00244-7
![](https://revistardp.org.br/public/journals/1/submission_1075_1075_coverImage_pt_BR.jpg)
Downloads
Publicado
Como Citar
Edição
Seção
Licença
Copyright (c) 2024 Victor Oliveira Araújo, Maria Carolina Marinho de Andrade Gonçalves, André Felipe Costa Alves, Ingrid Arruda Castro, Maria Isabel Sobreira Cavalcante, Ana Beatriz de Queiroz Büchler de Magalhães, Guilherme Dourado Aragão Sá Araujo, Caio Sérgio Gomes Sá, Lara Maria Fujita Vieira Lima, Lúcio Ibiapina Lima Maia Filho, Halisson Rodrigues de Andrade, Luciano Barroso de Albuquerque Filho, Camilla Costa Sallem, Lavínnya Yáskara de Aquino Matoso, Pedro Iughetti Morais, Júlio César Claudino dos Santos
![Creative Commons License](http://i.creativecommons.org/l/by-nc/4.0/88x31.png)
Este trabalho está licenciado sob uma licença Creative Commons Attribution-NonCommercial 4.0 International License.
Debates em Psiquiatria permite que o (s) autor (es) mantenha(m) seus direitos autorais sem restrições. Atribuição-NãoComercial 4.0 Internacional (CC BY-NC 4.0) - Debates em Psiquiatria é regida pela licença CC-BY-NC