Behavioral effect in experimental models of depression by gastrin releasing peptide microinjection via intra nucleus accumbens
DOI:
https://doi.org/10.25118/2763-9037.2021.v11.221Keywords:
Major Depressive Disorder, Depression, GRPAbstract
Introduction: Major Depressive Disorder is a common medical condition in the population, which can affect not only mental capacity, but also physical capacity, even causing incapacity for work. Its cause is still unknown, although some theories are gaining ground, such as the neurogenesis hypotheses as well as the neuroplasticity hypothesis, which emerged in a context where the classic monoamine hypothesis no longer explains all cases. In this context, a strong association between hyperactivity of the hypothalamic-pituitary-adrenal axis as well as gastroin-testinal tract hormones was highlighted in studies raising the hypothesis that depression has associated metabolic factors, even leading to the characterization of metabolic disease ac-cording to some authors. Objective: Thus, the present study seeks to analyze the behavioral effect of the gastrointestinal tract hormone GRP in view of the present evidence on its possible relationship with the patho-physiology of depression. Methods: Twenty Swiss mice were selected to perform the social defeat procedure, analysis with forced swimming test and intervention with Fluoxetine in the control and GRP in the experimental. Results: Social defeat stress increased the immobility time in the forced swim test by 13 seconds in the submissive mice, the GRP injection reduced the immobility time with a difference of 78 seconds for the control group treated with Fluoxetine. Conclusion: Thus, GRP, compared to other hor-mones studied in depression, had a positive effect on depres-sion and a possible therapy for its treatment.
Downloads
Metrics
References
Belujon P, Grace AA. Dopamine system dysregulation in major depressive disorders. Int J Neuropsychopharmacol. 2017;20(12):1036-46. https://doi.org/10.1093/ijnp/pyx056 - PMid:29106542 - PMCid:PMC5716179
Drevets WC, Price JL, Furey ML. Brain structural and functional abnormalities in mo-od disorders: Implications for neurocircuitry models of depression. Brain Struct Funct. 2008;213(1-2):93-118. https://doi.org/10.1007/s00429-008-0189-x - PMid:18704495 PMCid:PMC2522333
Francis TC, Lobo MK. Emerging Role for Nucleus Accumbens Medium Spiny Neuron Subtypes in Depression. Biol Psychiatry [Internet]. 2016;81(8):645-53. https://doi.org/10.1016/j.biopsych.2016.09.007 - PMid:27871668 PMCid:PMC5352537
Hendrickx H, McEwen BS, Ouderaa F Van Der. Metabolism, mood and cognition in aging: The importance of lifestyle and dietary intervention. Neurobiology of Aging. 2005; 26(1):1-5, Supplement, https://doi.org/10.1016/j.neurobiolaging.2005.10.005
Flor LS, Campos MR. Prevalência de diabetes mellitus e fatores associados na população adulta brasileira: evidências de um inquérito de base populacional. Rev Bras Epidemiol [Internet]. 2017;20(1):16-29. https://doi.org/10.1590/1980-5497201700010002 - PMid:28513791
Wexler DJ, Porneala B, Chang Y, Huang ES, Huffman JC, Grant RW. Diabetes differentially affects depression and selfrated health byage in the U.S. Diabetes Care. 2012;35(7):1575-7. https://doi.org/10.2337/dc11-2266 - PMid:22611066 PMCid:PMC3379579
Villanueva R. Neurobiology of Major Depressive Disorder. Psychosom Med. 2013;2013(2013):1-7. https://doi.org/10.1155/2013/873278 - PMid:24222865 PMCid:PMC3810062
Grippo AJ, Johnson AK. Stress, depression and cardiovascular dysregulation: A review of neurobiological mechanisms and the integration of research from preclinical disease models. Stress. 2009;12(1):1-21. https://doi.org/10.1080/10253890802046281 PMid:19116888 - PMCid:PMC2613299
Rohleder N, Schommer NC, Hellhammer DH, Engel R, Kirschbaum C. Sex differences in glucocorticoid sensitivity of proinflammatory cytokine production after psychosocial stress. Psychosom Med. 2001;63(6):966-72. https://doi.org/10.1097/00006842-200111000-00016 - PMid:11719636
Lutter M, Nestler EJ. Homeostatic and Hedonic Signals Interact in the Regulation of Food Intake. J Nutr [Internet]. 2009 Mar 1;139(3):629-32. https://doi.org/10.3945/jn.108.097618 - PMid:19176746 PMCid:PMC2714382
O'Kushky J, Ye P. Neurodevelopmental effects of insulin-like growth factor signaling. Front Neuroendocrinol. 2012;33(3):230-51. https://doi.org/10.1016/j.yfrne.2012.06.002 - PMid:22710100 PMCid:PMC3677055
Malberg JE, Platt B, Rizzo SJS, Ring RH, Lucki I, Schechter LE, Rosenzweig-Lipson S. Increasing the levels of insulin-like growth factor-I by an IGF binding protein inhibitor produces anxiolytic and antidepressant-like effects. Neuropsychopharmacology. 2007; 32(11):2360-8. https://doi.org/10.1038/sj.npp.1301358 - PMid:17342171
Hoshaw BA, Malberg JE, Lucki I. Central administration of IGF-I and BDNF leads to long-lasting antidepressant-like effects. Brain Res. 2005;1037(1-2):204-8. https://doi.org/10.1016/j.brainres.2005.01.007 - PMid:15777771
Becker C, Zeau B, Rivat C, Blugeot A, Hamon M, Benoliel JJ. Repeated social defeat-induced depression-like behavioral and biological alterations in rats: Involvement of cholecystokinin. Mol Psychiatry. 2008;13(12):1079-92. https://doi.org/10.1038/sj.mp.4002097 -PMid:17893702
Vialou V, Bagot RC, Cahill ME, Ferguson D, Robison AJ, Dietz DM, et al. Prefrontal Cortical Circuit for Depression and Anxiety-Related Behaviors Mediated by Cholecystokinin: Role of FosB. J Neurosci [Internet]. 2014;34(11):3878-87. https://doi.org/10.1523/JNEUROSCI.1787-13.2014 - PMid:24623766 PMCid:PMC3951691
Del Boca C, Lutz PE, Le Merrer J, Koebel P, Kieffer BL. Cholecystokinin knockdown in the basolateral amygdala has anxiolytic and antidepressant-like effects in mice. Neuroscience [Internet]. 2012 Aug 12;218(9):185-95. https://doi.org/10.1016/j.neuroscience.2012.05.022 - PMid:22613736 - PMCid:PMC3532740
Schwartsmann G, Henriques J, Roesler R. Gastrin-Releasing Peptide Receptor as a Molecular Target for Psychiatric and Neurological Disorders. CNS & Neurol Disord - Drug Targets [Internet]. 2006;5(2):197-204. https://doi.org/10.2174/187152706776359673 -PMid:16611092
Yao L, Chen J, Chen H, Xiang D, Yang C, Xiao L, Liu W, Wang H, Wang G, Zhu F, Liu Z. Hypothalamic gastrin-releasing peptide receptor mediates an antidepressant-like effect in a mouse model of stress. Am J Transl Res [Internet]. 2016;8(7):3097-105. PMID: 27508030 - PMCID: PMC4969446.
Monje FJ, Kim E-J, Cabatic M, Lubec G, Herkner KR, Pollak DD. A role for glucocor-ticoid-signaling in depression-like behavior of gastrin-releasing peptide receptor knock-out mice. Annals of Med [Internet]. 2011;43(5):389-402. https://doi.org/10.3109/07853890.2010.538716 - PMid:21254899
Roesler R, Kent P, Luft T, Schwartsmann G, Merali Z. Gastrin-releasing peptide receptor signaling in the integration of stress and memory. Neurobiol Learn Mem [Internet]. 2014;112:44-52. https://doi.org/10.1016/j.nlm.2013.08.013 - PMid:24001571
Flood JF, Morley JE. Effects of bombesin and gastrin-releasing peptide on memory processing. Brain Res. 1988;460(2):314-22. https://doi.org/10.1016/0006-8993(88)90375-7
Merali Z, Kent P, Du L, Hrdina P, Palkovits M, Faludi G, Poulter MO, Bédard T, Anisman H. Corticotropin-releasing hormone, arginine vasopressin, gastrin-releasing peptide, and neuromedin B alterations in stress-relevant brain regions of suicides and control subjects. Biol Psychiatry. 2006;59(7):594-602. https://doi.org/10.1016/j.biopsych.2005.08.008 - PMid:16197926
Merali Z, Anisman H, James JS, Kent P, Schulkin J. Effects of corticosterone on corticotrophin-releasing hormone and gastrin-releasing peptide release in response to an aversive stimulus in two regions of the forebrain (central nucleus of the amygdala and prefrontal cortex). Eur J Neurosci. 2008;28(1):165-72. https://doi.org/10.1111/j.1460-9568.2008.06281.x - PMid:18662341
Iniguez SD, Aubry A, Riggs LM, Alipio JB, Zanca RM, Flores-Ramirez FJ, Hernandez MA, Nieto, SJ, Musheyev D, Serrano PA. Social defeat stress induces depression-like behavior and alters spine morphology in the hip-pocampus of adolescent male C57BL/6 mice. Neurobiol Stress. 2016;5:54-64. https://doi.org/10.1016/j.ynstr.2016.07.001 - PMid:27981196 PMCid:PMC5154707
Riggs LM, Nieto SJ, Dayrit G, Zamora NN, Shawhan KL, Cruz B, Warren BL. Social defeat stress induces a depression-like phenotype in adolescent male c57BL/6 mice. HHS Public Access. 2014;17(3):247-55. https://doi.org/10.3109/10253890.2014.910650 - PMid:24689732 - PMCid:PMC5534169
Stepanichev M, Dygalo NN, Grigoryan G, Shishkina GT, Gulyaeva N. Rodent models of depression: Neurotrophic and neuroinflammatory biomarkers. Biomed Res Int. 2014;2014. https://doi.org/10.1155/2014/932757 - PMid:24999483 PMCid:PMC4066721
Tsankova NM, Berton O, Renthal W, Kumar A, Neve RL, Nestler EJ. Sustained hip-pocampal chromatin regulation in a mouse model of depression and antidepressant action. Nat Neurosci. 2006;9(4):519-25. https://doi.org/10.1038/nn1659 - PMid:16501568
Nikolaos Kokras, Dimitrios Baltas, Foivos Theocharis, Christina Dalla. Kinoscope: An Open-Source Computer Program for Behavioral Pharmacologists. Front Behav Neu-rosci | www.frontiersin.org [Internet]. 2017 [citado 25 de agosto de 2019];11(88):1-7. https://doi.org/10.3389/fnbeh.2017.00088 - PMid:28553211 PMCid:PMC5427106
Nicotine Exposure during Adolescence Induces a Depression-Like State in Adulthood. Neuropsychopharmacology [Internet]. 2009 May 17;34(6):1609-24. https://doi.org/10.1038/npp.2008.220 - PMid:19092782 - PMCid:PMC2692426
Qi J, Zhang S, Wang H, Barker DJ, Miranda-Barrientos J, Morales M. VTA glutama-tergic inputs to nucleus accumbens drive aversion by acting on GABAergic interneu-rons. Nat Neurosci [Internet]. 2016 May 28;19(5):725-33. https://doi.org/10.1038/nn.4281 - PMid:27019014 - PMCid:PMC4846550
El-Din AG, Aly MA, Ramadan MA, Mostafa M, Hamed SM. Behavioral Monitoring Tool. Egypt; 2011. Available at: http://ratmonitoring.sourceforge.net/#
Xiang D, Wang H, Sun S, Yao L, Li R, Zong X, Wang G, Liu Z. GRP Receptor Regulates Depression Behavior via Interaction With 5-HT2a Receptor. Front Psychiatry. 2020;10(January):1-9. https://doi.org/10.3389/fpsyt.2019.01020 - PMid:32047449 PMCid:PMC6997338
Wang P, Li H, Barde S, Zhang MD, Sun J, Wang T, Zhang P, Luo H, Wang Y, Yang Y, Wang C, Svenningsson P, Theodorsson E, Hokfelt TGM, Xu ZQD. Depression-like behavior in rat: Involvement of galanin receptor subtype 1 in the ventral periaqueductal gray. Proc Natl Acad Sci U S A. 2016;113(32):E4726-35. https://doi.org/10.1073/pnas.1609198113 - PMid:27457954 PMCid:PMC4987783
Prakash N, Stark CJ, Keisler MN, Luo L, Der-Avakian A, Dulcis D. Serotonergic plas-ticity in the dorsal raphe nucleus characterizes susceptibility and resilience to anhedo-nia. J Neurosci. 2020;40(3):569-84. https://doi.org/10.1523/JNEUROSCI.1802-19.2019 - PMid:31792153 - PMCid:PMC6961996
Savanthrapadian S, Meyer T, Elgueta C, Booker SA, Vida I, Bartos M. Synaptic properties of SOM-and CCK-expressing cells in dentate gyrus interneuron networks. J Neurosci. 2014;34(24):8197-209. https://doi.org/10.1523/JNEUROSCI.5433-13.2014 - PMid:24920624 - PMCid:PMC6608234
Hassan AM, Mancano G, Kashofer K, Fröhlich EE, Matak A, Mayerhofer R, Reichmann F, Olivares M, Neyrinck AM, Delzenne NM, Claus SP, Holzer P. High-fat diet induces depression-like behaviour in mice associated with changes in microbiome, neuropeptide Y, and brain metabolome. Nutr Neurosci. 2019;22(12):877-93. https://doi.org/10.1080/1028415X.2018.1465713 - PMid:29697017
Vialou V, Bagot RC, Cahill ME, Ferguson D, Robison AJ, Dietz DM, Fallon B, Mazei-Robison M, Ku SM, Harrigan E, Winstanley CA, Joshi T, Feng J, Berton O, Nestler EJ. Prefrontal cortical circuit for depression- and anxiety-related behaviors mediated by cholecysto-kinin: Role of ΔFosB. J Neurosci. 2014;34(11):3878-87. https://doi.org/10.1523/JNEUROSCI.1787-13.2014 - PMid:24623766 PMCid:PMC3951691
Choi J, Kim JE, Kim TK, Park JY, Lee JE, Kim H, Lee EH, Han PL. TRH and TRH receptor system in the basolateral amygdala mediate stress-induced depression-like behaviors. Neuropharmacology [Internet]. 2015;97:346-56. https://doi.org/10.1016/j.neuropharm.2015.03.030 - PMid:26107116
Witzmann FA, Li J, Strother WN, McBride WJ, Hunter L, Crabb DW, Lumeng L, Li TK. Innate differences in protein expression in the nucleus accumbens and hippocampus of inbred alcohol-preferring and -nonpreferring rats. In: Proteomics [Internet]. Proteomics; 2003 [citado 4 de outubro de 2020]. p. 1335-44. https://doi.org/10.1002/pmic.200300453 - PMid:12872235 PMCid:PMC2652869
Kramer DJ, Risso D, Kosillo P, Ngai J, Bateup HS. Combinatorial expression of Grp and Neurod6 defines dopamine neuron populations with distinct projection patterns and disease vulnerability. eNeuro [Internet]. 1 de maio de 2018 [citado 4 de outubro de 2020];5(3). https://doi.org/10.1523/ENEURO.0152-18.2018 - PMid:30135866 PMCid:PMC6104179
Xiang D, Wang H, Sun S, Yao L, Li R, Zong X, Wang G, Liu Z. GRP Receptor Regulates Depression Behavior via Interaction With 5-HT2a Receptor. Front Psychiatry. 2020;10(January):1-9. https://doi.org/10.3389/fpsyt.2019.01020 - PMid:32047449 PMCid:PMC6997338
Downloads
Published
How to Cite
Issue
Section
License
Copyright (c) 2021 Rodrigo de Almeida, Jorge Henna Neto, Eduardo Ernani Piazza da Silva
This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.
Debates em Psiquiatria allows the author (s) to keep their copyrights unrestricted. Allows the author (s) to retain their publication rights without restriction. Authors should ensure that the article is an original work without fabrication, fraud or plagiarism; does not infringe any copyright or right of ownership of any third party. Authors should also ensure that each one complies with the authorship requirements as recommended by the ICMJE and understand that if the article or part of it is flawed or fraudulent, each author shares responsibility.
Attribution-NonCommercial 4.0 International (CC BY-NC 4.0) - Debates em Psiquiatria is governed by the licencse CC-By-NC
You are free to:
- Share — copy and redistribute the material in any medium or format
- Adapt — remix, transform, and build upon the material
The licensor cannot revoke these freedoms as long as you follow the license terms. Under the following terms:
- Attribution — You must give appropriate credit, provide a link to the license, and indicate if changes were made. You may do so in any reasonable manner, but not in any way that suggests the licensor endorses you or your use.
- NonCommercial — You may not use the material for commercial purposes.
No additional restrictions — You may not apply legal terms or technological measures that legally restrict others from doing anything the license permits.
