When pregnancy and patient’s bipolarity becomes true
DOI:
https://doi.org/10.25118/2763-9037.2013.v3.369Keywords:
bipolar disorders, woman, pregnancyAbstract
There’s even a little more than 10 years, physicians advised women with bipolar disorder not to have children. Although this thinking is now outdated, they often still face difficult decisions about how to handle their treatment during pregnancy. Most drugs prescribed for bipolar disorder are associated with some risk of congenital malformations, but patients who discontinue the medication have a high risk of recurrence of a depressive, manic or mixed episode. During the postpartum period, the relapse rate
is even higher, reaching 50% to 70% by some estimates. And even more alarming: bipolar women are 100 times more likely than other women to develop postpartum psychosis, a severe condition that can result in maternal suicide and infanticide.
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• 1. Viguera AC, Whitfield T, Baldessarini RJ, Newport DJ, Stowe Z, Reminick A, et al. Risk of recurrence in women with bipolar disorder during pregnancy: prospective study of mood stabilizer discontinuation. The American journal of psychiatry. 2007 Dec 5;164:1817–24.
• 2. Viguera AC, Nonacs R, Cohen LS, Tondo L, Murray A, Baldessarini RJ. Risk of recurrence of bipolar disorder in pregnant and nonpregnant women after discontinuing lithium maintenance. The American journal of psychiatry. 2000 Feb 28;157:179–84.
• 3. Freeman MP, Smith KW, Freeman SA, McElroy SL, Kmetz GE, Wright R, et al. The impact of reproductive events on the course of bipolar disorder in women. The Journal of clinical psychiatry. 2002 May 8;63:284–7.
• 4. Rosa AR, Marco M, Fachel JMG, Kapczinski F, Stein AT, Barros HMT. Correlation between drug treatment adherence and lithium treatment attitudes and knowledge by bipolar patients. Progress in neuropsychopharmacology & biological psychiatry. 2006 Dec 24;31:217–24.
• 5. Benazzi F. Gender differences in bipolar-II disorder. Eur Arch Psychiatry Clin Neurosci. 2006;256:67–71.
• 6. Arnold LM, McElroy SL, Keck PE Jr. The role of gender in mixed mania. Compr Psychiatry. 2000;41:83–87.
• 7. Curtis V. Women are not the same as men: specific clinical issues for female patients with bipolar disorder. Bipolar disorders. 2005 Mar 13;7 Suppl 1:16–24.
• 8. Leibenluft E. Women with bipolar illness: clinical and research issues. Am J Psychiatry. 1996;153:163–173.
• 9. Altshuler LL, Kupka RW, Hellemann G, et al. Gender and depressive symptoms in 711 patients with bipolar disorder evaluated prospectively in the Stanley Foundation Bipolar Treatment Outcome Network. Am J Psychiatry. 2010;167:708–715.
• 10. Dias RS, Lafer B, Russo C, Del Debbio A, Nierenberg AA, Sachs GS, et al. Longitudinal follow-up of bipolar disorder in women with premenstrual exacerbation: findings from STEP-BD. The American journal of psychiatry. 2011 Apr 7;168:386–94.
• 11. Einarson TR, Lee C, Smith R, Manley J, Perstin J, Loniewska M, et al. Quality and content of abstracts in papers reporting about drug exposures during pregnancy. Birth defects research. Part A, Clinical and molecular teratology. 2006 Sep 27;76:621–8.
• 12. Bodén R, Lundgren M, Brandt L, Reutfors J, Andersen M, Kieler H. Risks of adverse pregnancy and birth outcomes in women treated or not treated with mood stabilisers for bipolar disorder: population based cohort study. BMJ (Clinical research ed.). 2012 Nov 8;345:e7085.
• 13. Lee H-C, Lin H-C. Maternal bipolar disorder increased low birthweight and preterm births: a nationwide population-based study. Journal of affective disorders. 2010 Jan 31;121:100–5.
• 14. Henin A, Biederman J, Mick E, Sachs GS, HirshfeldBecker DR, Siegel RS, et al. Psychopathology in the offspring of parents with bipolar disorder: a controlled study. Biological psychiatry. 2005 Oct 20;58:554–61.
• 15. Gentile S. Review presentation of available safety data on major psychotropic categories. Eur Neuropsychopharmacol 2012 ;22: S 150.
• 16. Cohen LS. Treatment of bipolar disorder during pregnancy. The Journal of clinical psychiatry. 2007 Sep 2;68 Suppl 9:4–9.
• 17. Cohen LS et al. Treatment of Mood Disorders During Pregnancy and Postpartum. Psychiatr Clin N Am. 2010;33:273-93.
• 18. Perucca E, Tomson T. Prenatal exposure to antiepileptic drugs. Lancet. 2006 May 7;367(9521):1467–9.
• 19. Nguyen HTT, Sharma V, McIntyre RS. Teratogenesis associated with antibipolar agents. Advances in therapy. 2009 Apr 13;26:281–94.
• 20. Viguera AC, Cohen LS, Whitfield T, Reminick AM, Bromfield E, Baldessarini RJ. Perinatal use of anticonvulsants: differences in attitudes and recommendations among neurologists and psychiatrists. Archives of women’s mental health. 2010 Mar 17;13:175–8.
• 21. Gentile S. Lithium in pregnancy: the need to treat, the duty to ensure safety. Expert opinion on drug safety. 2012 Apr 19;11:425–37.
• 22. Sabers A, Tomson T. Managing antiepileptic drugsduring pregnancy and lactation. Current opinion in neurology. 2009 Jun 16;22:157–61.
• 23. Gentile S. Antipsychotic therapy during early and late pregnancy. A systematic review. Schizophrenia bulletin. 2010 Jun 1;36:518–44.
• 24. Gentile S. Bipolar disorder in pregnancy: to treat or not to treat? BMJ (Clinical research ed.). 2012 Nov 11;345:e7367.
• 25. Terp IM, Mortensen PB. Post-partum psychoses. Clinical diagnoses and relative risk of admission after parturition. The British journal of psychiatry : the journal of mental science. 1998 Dec 6;172:521–6.
• 26. Viguera AC, Tondo L, Koukopoulos AE, Reginaldi D, Lepri B, Baldessarini RJ. Episodes of mood disorders in 2,252 pregnancies and postpartum periods. The American journal of psychiatry. 2011 Dec 29;168:1179–85.
• 27. Bergink V; Bouvy PF; Vervoort JSP; Koorengevel KM; Steegers EAP; Kushner SA: Prevention of postpartum psychosis and mania in women at high risk. Am J Psychiatry 2012; 169:609–615
• 28. Heron J, McGuinness M, Blackmore ER, Craddock N, Jones I. Early postpartum symptoms in puerperal psychosis. BJOG : an international journal of obstetrics and gynaecology. 2008 Jan 13;115:348–53.
• 29. Heron J, Robertson Blackmore E, McGuinness M, Craddock N, Jones I. No “latent period” in the onset of bipolar affective puerperal psychosis. Archives of women’s mental health. 2007 Apr 1;10:79–81.
• 30. Mendes Ribeiro JA, Vardanega S, Frey BN. O manejo dos transtornos psiquiátricos graves e persistentes: o papel das Unidades Materno-Infantis in_Rennó Jr J, Ribeiro HL. Tratado de Saúde Mental da Mulher. São Paulo, Atheneu, 1 Ed, 2012, 389-94.
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