Rhabdomyolysis secondary to zolpidem-induced seizures
DOI:
https://doi.org/10.25118/2763-9037.2023.v13.764Keywords:
seizures, drug misuse, rhabdomyolysis, substance-related disorders, zolpidemAbstract
Introduction: Rhabdomyolysis is a condition in which muscle destruction and necrosis occurs. Of varied etiology, it may be associated with convulsive crises. Zolpidem is a non-benzodiazepine sedative and hypnotic agent that under conditions of abuse and frequency can cause seizures. Case Report: Male, 26-year-old man was taken to the emergency room at a general hospital due to anxiety, where he had episodes of seizures. The condition progresses to rhabdomyolysis. History of zolpidem abuse. Discussion: High doses of zolpidem alter the selective agonism in the benzodiazepine-1 receptor and the abrupt withdrawal of the medication can lead to seizures with evolution, in severe cases, to rhabdomyolysis. Conclusions: Self-medication and abusive use of substances such as zolpidem have the potential to cause tolerance and dependence and may lead to life-threatening clinical conditions.
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