Interface de doenças endocrinológicas com repercussões psiquiátricas: uma revisão de literatura
DOI:
https://doi.org/10.25118/2763-9037.2021.v11.271Palavras-chave:
Endocrinologia, Psiquiatria, Psiquiatria BiológicaResumo
Introdução: várias síndromes clínicas podem apresentam sintomas neurológicos e psiquiátricos. Objetivo: este artigo está focado em descrever as principais síndromes endócrinas que podem cursar com alterações psiquiátricas. Método: foi realizada uma revisão de literatura por meio de busca e análise de artigos em inglês no Pubmed com descritores e complementada com referências dos artigos primários. Discussão: doenças da tireoide, como o hipotireoidismo e hipertireoidismo e doenças relacionadas às glândulas adrenais como Feocromocitoma, Doença de Addison e as Síndromes e Doença de Cushing podem ocasionar sintomas de ordem psiquiátrica, suprimindo sintomas já existentes ou intensificando os mesmos. Conclusão: pode-se perceber que o psiquiatra clínico deve manter atenção para as interfaces clínicas das doenças endócrinas uma vez que essas afecções podem mimetizar os quadros psiquiátricos mais comuns e saber como criar uma rotina de rastreio clínico e laboratorial para exclusão ou diagnóstico desses casos.
Downloads
Métricas
Referências
Isaac ML, Larson EB. Medical conditions with neuropsychiatric Manifestations. Med Clin North Am. 2014 Sep; 98(5):1193-208. http://dx.doi.org/10.1016/j.mcna.2014.06.012 - PMid:25134879
Feldman AZ, Shrestha RT, Hennessey JV. Neuropsychiatric Manifestations of Thyroid Disease. Endocrinology and Metabolism Clinics of North America. 2013. https://doi.org/10.1016/j.ecl.2013.05.005 - PMid:24011880
Lee KA, Park KT, Yu HM, Jin HY, Baek HS, Park TS. Subacute thyroiditis presenting as acute psychosis: a case report and literature review. Korean J Intern Med [Internet]. 2013 Mar [cited 2019 Jul 23];28(2):242-6. Available from: http://www.ncbi.nlm.nih.gov/pubmed/23526704 - https://doi.org/10.3904/kjim.2013.28.2.242 - PMid:23526704 - PMCid:PMC3604616
Ittermann T, Völzke H, Baumeister SE, Appel K, Grabe HJ. Diagnosed thyroid disorders are associated with depression and anxiety. Soc Psychiatry Psychiatr Epidemiol [Internet]. 2015 Sep [cited 2019 Jul 23];50(9):1417-25. Available from: http://www.ncbi.nlm.nih.gov/pubmed/25777685 - https://doi.org/10.1007/s00127-015-1043-0 - PMid:25777685
Siegmann EM, Müller HHO, Luecke C, Philipsen A, Kornhuber J, Grömer TW. Association of depression and anxiety disorders with autoimmune thyroiditis: A systematic review and meta-analysis. JAMA Psychiatry.2018. https://doi.org/10.1001/jamapsychiatry.2018.0190 - PMid:29800939 PMCid:PMC6137529
Khemka D, Ali JA, Koch CA. Primary hypothyroidism associated with acute mania: Case series and literature review. Experimental and Clinical Endocrinology and Diabetes. 2011. https://doi.org/10.1055/s-0031-1277137 - PMid:21553358
Loh HH, Lim LL, Yee A, Loh HS. Association between subclinical hypothyroidism and depression: An updated systematic review and meta-analysis. BMC Psychiatry. 2019. https://doi.org/10.1186/s12888-018-2006-2 - PMid:30621645 PMCid:PMC6325749
Tang R, Wang J, Yang L, Ding X, Zhong Y, Pan J, et al. Subclinical Hypothyroidism and Depression: A Systematic Review and Meta-Analysis. Front Endocrinol (Lausanne). 2019. https://doi.org/10.3389/fendo.2019.00340 - PMid:31214119 PMCid:PMC6558168
Cohen BM, Sommer BR, Vuckovic A. Antidepressant-resistant depression in patients with comorbid subclinical hypothyroidism or high-normal TSH levels. Am J Psychiatry. 2018. https://doi.org/10.1176/appi.ajp.2017.17080949 - PMid:29961367
Swee DS, Chng CL, Lim A. Clinical characteristics and outcome of thyroid storm: a case series and review of neuropsychiatric derangements in thyrotoxicosis. Endocr Pract [Internet]. 2015 Feb [cited 2019 Jul 23];21(2):182-9. Available from: http://www.ncbi.nlm.nih.gov/pubmed/25370315 - https://doi.org/10.4158/EP14023.OR - PMid:25370315
Golub D, Rodack V. Antipsychotics in Hyperthyroid-Related Psychosis: Case Report and Systematic Review. Neuro Endocrinol Lett [Internet]. 2018 Mar [cited 2019 Aug 23];39(1):65-74. Available from: http://www.ncbi.nlm.nih.gov/pubmed/29803209
Gunawardane PTK, Grossman A. Phaeochromocytoma and Paraganglioma. Adv Exp Med Biol [Internet]. 2017 [cited 2019 Jul 24];956:239-59. Available from: http://www.ncbi.nlm.nih.gov/pubmed/27888488 - https://doi.org/10.1007/5584_2016_76 - PMid:27888488
Medvei VC, Cattell WR. Mental symptoms presenting in phaeochromocytoma: a case report and review. J R Soc Med [Internet]. 1988 Sep [cited 2019 Jul 24];81(9):550-1. Available from: http://www.ncbi.nlm.nih.gov/pubmed/3054110 https://doi.org/10.1177/014107688808100923 - PMid:3054110 PMCid:PMC1291775
Brown JS. Cases of remission of psychosis following resection of pheochromocytoma or paraganglioma. Schizophr Res. 2016. https://doi.org/10.1016/j.schres.2016.08.012 - PMid:27534680
Leung A, Zun L, Nordstrom K, Wilson MP. Psychiatric Emergencies for Physicians: Clinical Management and Approach to Distinguishing Pheochromocytoma From Psychiatric and Thyrotoxic Diseases in the Emergency Department. J Emerg Med [Internet]. 2017 Nov [cited 2019 Jul 24];53(5):712-6. Available from: http://www.ncbi.nlm.nih.gov/pubmed/28874302 - https://doi.org/10.1016/j.jemermed.2017.05.032 - PMid:28874302
Addison T: On the Constitutional and Local Effects of Disease of the Suprarenal Capsules. Birmingham, Ala, Classics of Medicine Library, 1980
Oelkers W: Adrenal Insufficiency. N Engl J Med 1996; 335:1206- 1212. https://doi.org/10.1056/NEJM199610173351607 - PMid:8815944
Eisenbarth GS, Gottlieb PA. Autoimmune polyendocrine syndromes. N Engl J Med 2004; 350:2068-2079. https://doi.org/10.1056/NEJMra030158 - PMid:15141045
Dekkers OM, van der Klaauw AA, Pereira AM, Biermasz NR, Honkoop PJ, Roelfsema F, Smit JW, Romijn JA. Quality of life is decreased after treatment for nonfunctioning pituitary macroadenoma. J Clin Endocrinol Metab 2006; 91:3364-3369. https://doi.org/10.1210/jc.2006-0003 - PMid:16787991
Løvas K, Husebye ES. High prevalence and increasing incidence of Addison's disease in western Norway. Clin Endocrinol (Oxf). 2002;56:787-91. https://doi.org/10.1046/j.1365-2265.2002.t01-1-01552.x - PMid:12072049
Erichsen MM, Løva˚s K, Skinningsrud B, Wolff AB, Undlien DE, Svartberg J, Fougner KJ, Berg TJ, Bollerslev J, Mella B, Carlson JA, Erlich H, Husebye ES. Clinical, immunological, and genetic features of autoimmune primary adrenal insufficiency: observations from a Norwegian registry. J Clin Endocrinol Metab. 2009;94:4882-90. https://doi.org/10.1210/jc.2009-1368 - PMid:19858318
Thomsen AF, Kvist TK, Andersen PK, Kessing LV. The risk of affective disorders in patients with adrenocortical insufficiency. Psychoneuroendocrinology. 2006;31:614-22. https://doi.org/10.1016/j.psyneuen.2006.01.003 - PMid:16545526
Holtzman CW, Trotman HD, Goulding SM, Ryan AT, MacDonald AN, Shapiro DI, Brasfield JL, Walker EF. Stress and neurodevelopmental processes in the emergence of psychosis. Neuroscience. 2013;249:172-91. https://doi.org/10.1016/j.neuroscience.2012.12.017 - PMid:23298853 - PMCid:PMC4140178
Gould E, Woolley CS, McEwen BS. Short-term glucocorticoid manipulations affect neuronal morphology and survival in the adult dentate gyrus. Neuroscience 1990; 37:367-375. https://doi.org/10.1016/0306-4522(90)90407-U
Squire LR, Zola-Morgan S. Memory: brain systems and behavior. Trends Neurosci 1988. https://doi.org/10.1016/0166-2236(88)90144-0
Mizoguchi K, Ishige A, Takeda S, Aburada M, Tabira T. Endogenous glucocorticoids are essential for maintaining prefrontal cortical cognitive function. J Neurosci 2004; 24:5492-5499. https://doi.org/10.1523/JNEUROSCI.0086-04.2004 - PMid:15201321 - PMCid:PMC6729338
Filipsson H, Monson JP, Koltowska-Haggstrom M, Mattsson A, Johannsson G. The impact of glucocorticoid replacement regimens on metabolic outcome and comorbidity in hypopituitary patients. J Clin Endocrinol Metab 2006;91:3954-3961. https://doi.org/10.1210/jc.2006-0524 - PMid:16895963
Johannsson G, Falorni A, Skrtic S, Lennernas H, Quinkler M, Monson JP, Stewart PM. Adrenal insufficiency: review of clinical outcomes with current glucocorticoid replacement therapy. Clin Endocrinol (Oxf) 2015; 82:2-11. https://doi.org/10.1111/cen.12603 - PMid:25187037
Bornstein SR, Allolio B, Arlt W, et al. Diagnosis and Treatment of Primary Adrenal Insufficiency: An Endocrine Society Clinical Practice Guideline. J Clin Endocrinol Metab 2016; 101:364. https://doi.org/10.1210/jc.2015-1710 - PMid:26760044 PMCid:PMC4880116
Grossman AB. Clinical Review: The diagnosis and management of central hypoadrenalism. J Clin Endocrinol Metab 2010; 95:4855. https://doi.org/10.1210/jc.2010-0982 - PMid:20719838
Anglin RE, Rosebush PI, Mazurek MF. The Neuropsychiatric Profile of Addison's Disease: Revisiting a Forgotten Phenomenon. J Neuropsychiatry Clin Neurosci. 2006;18(4):450-9. http://doi.org/10.1176/jnp.2006.18.4.450 - PMID:17135373
Newell-Price J, Bertagna X, Grossman AB, Nieman LK. Cushing's syndrome. Lancet 2006;367:1605-1617. https://doi.org/10.1016/S0140-6736(06)68699-6
Pivonello R, Simeoli C, De Martino MC, Cozzolino A, De Leo M, Iacuaniello D, Pivonello C, Negri M, Pellecchia MT, Iasevoli F, Colao A. Neuropsychiatric disorders in Cushing's syndrome. Front. Neurosci. 2015,9,129. https://doi.org/10.3389/fnins.2015.00129 PMid:25941467 - PMCid:PMC4403344
Merke DP, Giedd JN, Keil MF, Mehlinger SL, Wiggs EA, Holzer S, Rawson E, Vaituzis AC, Stratakis CA, Chrousos GP. Children experience cognitive decline despite reversal of brain atrophy one year after resolution of Cushing syndrome. J Clin Endocrinol Metab 2005;90:2531-2536. https://doi.org/10.1210/jc.2004-2488 - PMid:15741254
Bauduin SEEC, van der Wee NJA, van der Werff SJA. Curr Opin Endocrinol Diabetes Obes. 2018 Aug;25(4):285-289. https://doi.org/10.1097/MED.0000000000000414 - PMid:29746308
Simmons NE, Do HM, Lipper MH, Laws ER Jr. Cerebral atrophy in Cushing's disease. Surg Neurol 2000; 53:72-76. https://doi.org/10.1016/S0090-3019(99)00197-4
Resmini E, Santos A, Gomez-Anson B, Vives Y, Pires P, Crespo I, Portella MJ, Juan-Delago M, Barahona MJ, Webb SM. Verbal and visual memory performance and hippocampal volumes, measured by 3-Tesla magnetic resonance imaging, in patients with Cushing's syndrome. J Clin Endocrinol Metab 2012; 97:663-671. https://doi.org/10.1210/jc.2011-2231 - PMid:22162471
Santos A, Resmini E, Crespo I, Pires P, Vives-Gilabert Y, Granell E, Valassi E, Gómez-Anson B, Martínez-Momblán MA, Mataró M, Webb SM. Small cerebellar cortex volume in patients with active Cushing's syndrome. Eur J Endocrinol 2014; 171:461-469. https://doi.org/10.1530/EJE-14-0371 - PMid:25005936
Cohen SI. Cushing's syndrome: a psychiatric study of 29 patients. Br J Psychiatry 1980; 136:120-124. https://doi.org/10.1192/bjp.136.2.120 - PMid:7370477
Kelly WF, Kelly MJ, Faragher B. A prospective study of psychiatric and psychological aspects of Cushing's syndrome. Clin Endocrinol (Oxf) 1996; 45:715-720. https://doi.org/10.1046/j.1365-2265.1996.8690878.x - PMid:9039337
Tiemensma J, Biermasz NR, Middelkoop HA, van der Mast RC, Romijn JA, Pereira AM. Increased prevalence of psychopathology and maladaptive personality traits after long-term cure of Cushing's disease. J Clin Endocrinol Metab 2010;95:E129-E141. https://doi.org/10.1210/jc.2010-0512 - PMid:20660031
Tiemensma J, Kokshoorn NE, Biermasz NR, Keijser BJSA, Wassenaar MJE, Middelkoop HAM, Pereira AM, Romijnet JA. Subtle cognitive impairments in patients with long-term cure of Cushing's disease. J Clin Endocrinol Metab 2010;95:2699-2714. https://doi.org/10.1210/jc.2009-2032 - PMid:20371667
Nieman LK, Biller BM, Findling JW, Murad MH, Newell-Price J, Savage MO, Tabarinet A. Treatment of Cushing's syndrome: an Endocrine Society clinical practice guideline. J Clin Endocrinol Metab. 2015;100:2807-31. https://doi.org/10.1210/jc.2015-1818 - PMid:26222757 PMCid:PMC4525003
Sonino N, Fallo F, Fava GA. Psychosomatic aspects of Cushing's syndrome. Rev Endocr Metab Disord. 2010;11:95-104. https://doi.org/10.1007/s11154-009-9123-7 - PMid:19960264
Starkman MN. Neuropsychiatric findings in Cushing's syndrome and exogenous glucocorticoid administration. Endocrinol Metab Clin N Am. 2013;42:477-88. https://doi.org/10.1016/j.ecl.2013.05.010 PMid:24011881
Santos A, Resmini E, Pascual JC, Crespo I, Webb SM. Psychiatric Symptoms in Patients with Cushing's Syndrome: Prevalence, Diagnosis and Management. Drugs. 2017 May;77(8):829-842. https://doi.org/10.1007/s40265-017-0735-z - PMID:28393326.
Sonino N, Fava GA. Psychiatric disorders associated with Cushing's syndrome: epidemiology, pathophysiology and treatment. CNS Drugs. 2001;15:361-73. https://doi.org/10.2165/00023210-200115050-00003 - PMid:11475942
Dorn LD, Burgess ES, Friedman TC, Dubbert B, Gold PW, Chrousos GP. The longitudinal course of psychopathology in Cushing's syndrome after correction of hypercortisolism. J Clin Endocrinol Metab. 1997;82:912-9. https://doi.org/10.1210/jc.82.3.912 - https://doi.org/10.1210/jcem.82.3.3834 - PMid:9062506
Downloads
Publicado
Como Citar
Edição
Seção
Licença
Copyright (c) 2021 Daniell de Siqueira Araújo Lafayette, Phillip de Azevedo Costa Urquiza, Eveline Maria Cosmo de Brito, Silvia Poliana Guedes Alcoforado Costa, Amaury Cantilino da Silva Júnior
Este trabalho está licenciado sob uma licença Creative Commons Attribution-NonCommercial 4.0 International License.
Debates em Psiquiatria permite que o (s) autor (es) mantenha(m) seus direitos autorais sem restrições. Atribuição-NãoComercial 4.0 Internacional (CC BY-NC 4.0) - Debates em Psiquiatria é regida pela licença CC-BY-NC