Interface of endocrinological diseases with psychiatric repercussions: a literature review

Authors

DOI:

https://doi.org/10.25118/2763-9037.2021.v11.271

Keywords:

Endocrinology, Psychiatry, Biological Psychiatry

Abstract

Introduction: Several clinical syndromes can present neurological and psychiatric symptoms.  Objective: This article is focused on describing the main endocrines syndromes witch can be developed with psychiatric disorders. Method: A literature review was carried out by searching and analyzing articles in English at Pubmed with descriptors and complemented with references from primary articles. Discussion: thyroid diseases as hypothyroidism and hyperthyroidism and diseases related to the adrenal glands as pheochromocytoma, Addison's disease and Cushing's syndromes and disease can cause psychiatric symptoms, either suppressing existing symptoms or intensifying them. Conclusion: it can be verified that the clinical psychiatrist must maintain attention to the clinical interfaces of endocrine diseases since these conditions can mimic the most common psychiatric conditions and must to know how to create a routine clinical and laboratory screening to exclude or diagnose these cases.

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References

Isaac ML, Larson EB. Medical conditions with neuropsychiatric Manifestations. Med Clin North Am. 2014 Sep; 98(5):1193-208. http://dx.doi.org/10.1016/j.mcna.2014.06.012 - PMid:25134879

Feldman AZ, Shrestha RT, Hennessey JV. Neuropsychiatric Manifestations of Thyroid Disease. Endocrinology and Metabolism Clinics of North America. 2013. https://doi.org/10.1016/j.ecl.2013.05.005 - PMid:24011880

Lee KA, Park KT, Yu HM, Jin HY, Baek HS, Park TS. Subacute thyroiditis presenting as acute psychosis: a case report and literature review. Korean J Intern Med [Internet]. 2013 Mar [cited 2019 Jul 23];28(2):242-6. Available from: http://www.ncbi.nlm.nih.gov/pubmed/23526704 - https://doi.org/10.3904/kjim.2013.28.2.242 - PMid:23526704 - PMCid:PMC3604616

Ittermann T, Völzke H, Baumeister SE, Appel K, Grabe HJ. Diagnosed thyroid disorders are associated with depression and anxiety. Soc Psychiatry Psychiatr Epidemiol [Internet]. 2015 Sep [cited 2019 Jul 23];50(9):1417-25. Available from: http://www.ncbi.nlm.nih.gov/pubmed/25777685 - https://doi.org/10.1007/s00127-015-1043-0 - PMid:25777685

Siegmann EM, Müller HHO, Luecke C, Philipsen A, Kornhuber J, Grömer TW. Association of depression and anxiety disorders with autoimmune thyroiditis: A systematic review and meta-analysis. JAMA Psychiatry.2018. https://doi.org/10.1001/jamapsychiatry.2018.0190 - PMid:29800939 PMCid:PMC6137529

Khemka D, Ali JA, Koch CA. Primary hypothyroidism associated with acute mania: Case series and literature review. Experimental and Clinical Endocrinology and Diabetes. 2011. https://doi.org/10.1055/s-0031-1277137 - PMid:21553358

Loh HH, Lim LL, Yee A, Loh HS. Association between subclinical hypothyroidism and depression: An updated systematic review and meta-analysis. BMC Psychiatry. 2019. https://doi.org/10.1186/s12888-018-2006-2 - PMid:30621645 PMCid:PMC6325749

Tang R, Wang J, Yang L, Ding X, Zhong Y, Pan J, et al. Subclinical Hypothyroidism and Depression: A Systematic Review and Meta-Analysis. Front Endocrinol (Lausanne). 2019. https://doi.org/10.3389/fendo.2019.00340 - PMid:31214119 PMCid:PMC6558168

Cohen BM, Sommer BR, Vuckovic A. Antidepressant-resistant depression in patients with comorbid subclinical hypothyroidism or high-normal TSH levels. Am J Psychiatry. 2018. https://doi.org/10.1176/appi.ajp.2017.17080949 - PMid:29961367

Swee DS, Chng CL, Lim A. Clinical characteristics and outcome of thyroid storm: a case series and review of neuropsychiatric derangements in thyrotoxicosis. Endocr Pract [Internet]. 2015 Feb [cited 2019 Jul 23];21(2):182-9. Available from: http://www.ncbi.nlm.nih.gov/pubmed/25370315 - https://doi.org/10.4158/EP14023.OR - PMid:25370315

Golub D, Rodack V. Antipsychotics in Hyperthyroid-Related Psychosis: Case Report and Systematic Review. Neuro Endocrinol Lett [Internet]. 2018 Mar [cited 2019 Aug 23];39(1):65-74. Available from: http://www.ncbi.nlm.nih.gov/pubmed/29803209

Gunawardane PTK, Grossman A. Phaeochromocytoma and Paraganglioma. Adv Exp Med Biol [Internet]. 2017 [cited 2019 Jul 24];956:239-59. Available from: http://www.ncbi.nlm.nih.gov/pubmed/27888488 - https://doi.org/10.1007/5584_2016_76 - PMid:27888488

Medvei VC, Cattell WR. Mental symptoms presenting in phaeochromocytoma: a case report and review. J R Soc Med [Internet]. 1988 Sep [cited 2019 Jul 24];81(9):550-1. Available from: http://www.ncbi.nlm.nih.gov/pubmed/3054110 https://doi.org/10.1177/014107688808100923 - PMid:3054110 PMCid:PMC1291775

Brown JS. Cases of remission of psychosis following resection of pheochromocytoma or paraganglioma. Schizophr Res. 2016. https://doi.org/10.1016/j.schres.2016.08.012 - PMid:27534680

Leung A, Zun L, Nordstrom K, Wilson MP. Psychiatric Emergencies for Physicians: Clinical Management and Approach to Distinguishing Pheochromocytoma From Psychiatric and Thyrotoxic Diseases in the Emergency Department. J Emerg Med [Internet]. 2017 Nov [cited 2019 Jul 24];53(5):712-6. Available from: http://www.ncbi.nlm.nih.gov/pubmed/28874302 - https://doi.org/10.1016/j.jemermed.2017.05.032 - PMid:28874302

Addison T: On the Constitutional and Local Effects of Disease of the Suprarenal Capsules. Birmingham, Ala, Classics of Medicine Library, 1980

Oelkers W: Adrenal Insufficiency. N Engl J Med 1996; 335:1206- 1212. https://doi.org/10.1056/NEJM199610173351607 - PMid:8815944

Eisenbarth GS, Gottlieb PA. Autoimmune polyendocrine syndromes. N Engl J Med 2004; 350:2068-2079. https://doi.org/10.1056/NEJMra030158 - PMid:15141045

Dekkers OM, van der Klaauw AA, Pereira AM, Biermasz NR, Honkoop PJ, Roelfsema F, Smit JW, Romijn JA. Quality of life is decreased after treatment for nonfunctioning pituitary macroadenoma. J Clin Endocrinol Metab 2006; 91:3364-3369. https://doi.org/10.1210/jc.2006-0003 - PMid:16787991

Løvas K, Husebye ES. High prevalence and increasing incidence of Addison's disease in western Norway. Clin Endocrinol (Oxf). 2002;56:787-91. https://doi.org/10.1046/j.1365-2265.2002.t01-1-01552.x - PMid:12072049

Erichsen MM, Løva˚s K, Skinningsrud B, Wolff AB, Undlien DE, Svartberg J, Fougner KJ, Berg TJ, Bollerslev J, Mella B, Carlson JA, Erlich H, Husebye ES. Clinical, immunological, and genetic features of autoimmune primary adrenal insufficiency: observations from a Norwegian registry. J Clin Endocrinol Metab. 2009;94:4882-90. https://doi.org/10.1210/jc.2009-1368 - PMid:19858318

Thomsen AF, Kvist TK, Andersen PK, Kessing LV. The risk of affective disorders in patients with adrenocortical insufficiency. Psychoneuroendocrinology. 2006;31:614-22. https://doi.org/10.1016/j.psyneuen.2006.01.003 - PMid:16545526

Holtzman CW, Trotman HD, Goulding SM, Ryan AT, MacDonald AN, Shapiro DI, Brasfield JL, Walker EF. Stress and neurodevelopmental processes in the emergence of psychosis. Neuroscience. 2013;249:172-91. https://doi.org/10.1016/j.neuroscience.2012.12.017 - PMid:23298853 - PMCid:PMC4140178

Gould E, Woolley CS, McEwen BS. Short-term glucocorticoid manipulations affect neuronal morphology and survival in the adult dentate gyrus. Neuroscience 1990; 37:367-375. https://doi.org/10.1016/0306-4522(90)90407-U

Squire LR, Zola-Morgan S. Memory: brain systems and behavior. Trends Neurosci 1988. https://doi.org/10.1016/0166-2236(88)90144-0

Mizoguchi K, Ishige A, Takeda S, Aburada M, Tabira T. Endogenous glucocorticoids are essential for maintaining prefrontal cortical cognitive function. J Neurosci 2004; 24:5492-5499. https://doi.org/10.1523/JNEUROSCI.0086-04.2004 - PMid:15201321 - PMCid:PMC6729338

Filipsson H, Monson JP, Koltowska-Haggstrom M, Mattsson A, Johannsson G. The impact of glucocorticoid replacement regimens on metabolic outcome and comorbidity in hypopituitary patients. J Clin Endocrinol Metab 2006;91:3954-3961. https://doi.org/10.1210/jc.2006-0524 - PMid:16895963

Johannsson G, Falorni A, Skrtic S, Lennernas H, Quinkler M, Monson JP, Stewart PM. Adrenal insufficiency: review of clinical outcomes with current glucocorticoid replacement therapy. Clin Endocrinol (Oxf) 2015; 82:2-11. https://doi.org/10.1111/cen.12603 - PMid:25187037

Bornstein SR, Allolio B, Arlt W, et al. Diagnosis and Treatment of Primary Adrenal Insufficiency: An Endocrine Society Clinical Practice Guideline. J Clin Endocrinol Metab 2016; 101:364. https://doi.org/10.1210/jc.2015-1710 - PMid:26760044 PMCid:PMC4880116

Grossman AB. Clinical Review: The diagnosis and management of central hypoadrenalism. J Clin Endocrinol Metab 2010; 95:4855. https://doi.org/10.1210/jc.2010-0982 - PMid:20719838

Anglin RE, Rosebush PI, Mazurek MF. The Neuropsychiatric Profile of Addison's Disease: Revisiting a Forgotten Phenomenon. J Neuropsychiatry Clin Neurosci. 2006;18(4):450-9. http://doi.org/10.1176/jnp.2006.18.4.450 - PMID:17135373

Newell-Price J, Bertagna X, Grossman AB, Nieman LK. Cushing's syndrome. Lancet 2006;367:1605-1617. https://doi.org/10.1016/S0140-6736(06)68699-6

Pivonello R, Simeoli C, De Martino MC, Cozzolino A, De Leo M, Iacuaniello D, Pivonello C, Negri M, Pellecchia MT, Iasevoli F, Colao A. Neuropsychiatric disorders in Cushing's syndrome. Front. Neurosci. 2015,9,129. https://doi.org/10.3389/fnins.2015.00129 PMid:25941467 - PMCid:PMC4403344

Merke DP, Giedd JN, Keil MF, Mehlinger SL, Wiggs EA, Holzer S, Rawson E, Vaituzis AC, Stratakis CA, Chrousos GP. Children experience cognitive decline despite reversal of brain atrophy one year after resolution of Cushing syndrome. J Clin Endocrinol Metab 2005;90:2531-2536. https://doi.org/10.1210/jc.2004-2488 - PMid:15741254

Bauduin SEEC, van der Wee NJA, van der Werff SJA. Curr Opin Endocrinol Diabetes Obes. 2018 Aug;25(4):285-289. https://doi.org/10.1097/MED.0000000000000414 - PMid:29746308

Simmons NE, Do HM, Lipper MH, Laws ER Jr. Cerebral atrophy in Cushing's disease. Surg Neurol 2000; 53:72-76. https://doi.org/10.1016/S0090-3019(99)00197-4

Resmini E, Santos A, Gomez-Anson B, Vives Y, Pires P, Crespo I, Portella MJ, Juan-Delago M, Barahona MJ, Webb SM. Verbal and visual memory performance and hippocampal volumes, measured by 3-Tesla magnetic resonance imaging, in patients with Cushing's syndrome. J Clin Endocrinol Metab 2012; 97:663-671. https://doi.org/10.1210/jc.2011-2231 - PMid:22162471

Santos A, Resmini E, Crespo I, Pires P, Vives-Gilabert Y, Granell E, Valassi E, Gómez-Anson B, Martínez-Momblán MA, Mataró M, Webb SM. Small cerebellar cortex volume in patients with active Cushing's syndrome. Eur J Endocrinol 2014; 171:461-469. https://doi.org/10.1530/EJE-14-0371 - PMid:25005936

Cohen SI. Cushing's syndrome: a psychiatric study of 29 patients. Br J Psychiatry 1980; 136:120-124. https://doi.org/10.1192/bjp.136.2.120 - PMid:7370477

Kelly WF, Kelly MJ, Faragher B. A prospective study of psychiatric and psychological aspects of Cushing's syndrome. Clin Endocrinol (Oxf) 1996; 45:715-720. https://doi.org/10.1046/j.1365-2265.1996.8690878.x - PMid:9039337

Tiemensma J, Biermasz NR, Middelkoop HA, van der Mast RC, Romijn JA, Pereira AM. Increased prevalence of psychopathology and maladaptive personality traits after long-term cure of Cushing's disease. J Clin Endocrinol Metab 2010;95:E129-E141. https://doi.org/10.1210/jc.2010-0512 - PMid:20660031

Tiemensma J, Kokshoorn NE, Biermasz NR, Keijser BJSA, Wassenaar MJE, Middelkoop HAM, Pereira AM, Romijnet JA. Subtle cognitive impairments in patients with long-term cure of Cushing's disease. J Clin Endocrinol Metab 2010;95:2699-2714. https://doi.org/10.1210/jc.2009-2032 - PMid:20371667

Nieman LK, Biller BM, Findling JW, Murad MH, Newell-Price J, Savage MO, Tabarinet A. Treatment of Cushing's syndrome: an Endocrine Society clinical practice guideline. J Clin Endocrinol Metab. 2015;100:2807-31. https://doi.org/10.1210/jc.2015-1818 - PMid:26222757 PMCid:PMC4525003

Sonino N, Fallo F, Fava GA. Psychosomatic aspects of Cushing's syndrome. Rev Endocr Metab Disord. 2010;11:95-104. https://doi.org/10.1007/s11154-009-9123-7 - PMid:19960264

Starkman MN. Neuropsychiatric findings in Cushing's syndrome and exogenous glucocorticoid administration. Endocrinol Metab Clin N Am. 2013;42:477-88. https://doi.org/10.1016/j.ecl.2013.05.010 PMid:24011881

Santos A, Resmini E, Pascual JC, Crespo I, Webb SM. Psychiatric Symptoms in Patients with Cushing's Syndrome: Prevalence, Diagnosis and Management. Drugs. 2017 May;77(8):829-842. https://doi.org/10.1007/s40265-017-0735-z - PMID:28393326.

Sonino N, Fava GA. Psychiatric disorders associated with Cushing's syndrome: epidemiology, pathophysiology and treatment. CNS Drugs. 2001;15:361-73. https://doi.org/10.2165/00023210-200115050-00003 - PMid:11475942

Dorn LD, Burgess ES, Friedman TC, Dubbert B, Gold PW, Chrousos GP. The longitudinal course of psychopathology in Cushing's syndrome after correction of hypercortisolism. J Clin Endocrinol Metab. 1997;82:912-9. https://doi.org/10.1210/jc.82.3.912 - https://doi.org/10.1210/jcem.82.3.3834 - PMid:9062506

Published

2021-12-29

How to Cite

1.
Lafayette DSA, Urquiza PAC, Brito EMC, Costa SPGA, Cantilino A. Interface of endocrinological diseases with psychiatric repercussions: a literature review. Debates em Psiquiatria [Internet]. 2021 Dec. 29 [cited 2024 Dec. 22];11:1-19. Available from: https://revistardp.org.br/revista/article/view/271

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