ADHD neuroimaging: findings from structural and functional magnetic resonance imaging

Authors

  • Felipe Almeida Picon Programa de Transtornos de Déficit de Atenção/Hiperatividade em Adultos – ProDAH-A – Hospital de Clínicas de Porto Alegre – Universidade Federal do Rio Grande do Sul – UFRGS; Instituto Nacional de Psiquiatria do Desenvolvimento – INPD; Grupo de Estudos sobre Adições Tecnológicas – GEAT.

DOI:

https://doi.org/10.25118/2763-9037.2014.v4.248

Keywords:

ADHD, structural MRI, functional MRI, default mode network, intrinsic functional connectivity, resting state functional connectivity

Abstract

This review first describes the operation of the following MRI methodologies: Voxel-based morphometry, surface-based morphometry, diffusion tensor imaging, task-based fMRI and resting state fMRI. Then brings the key findings of these techniques in the study of ADHD.

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References

Matthews M, Nigg JT, Fair DA. Attention Deficit Hyperactivity Disorder. Curr Top Behav Neurosci. 2013;11.Epub ahead of print. https://doi.org/10.1007/978-3-662-45758-0_249 DOI: https://doi.org/10.1007/978-3-662-45758-0_249

Cortese S, Castellanos FX. Neuroimaging of attentiondeficit/hyperactivity disorder: current neuroscience-informed perspectives for clinicians. Curr Psychiatry Rep. 2012;14:568-78. https://doi.org/10.1007/s11920-012-0310-y DOI: https://doi.org/10.1007/s11920-012-0310-y

Valera EM, Faraone SV, Murray KE, Seidman LJ. Meta-analysis of structural imaging findings in attention-deficit/ hyperactivity disorder. Biol Psychiatry. 2007;61:1361-9. https://doi.org/10.1016/j.biopsych.2006.06.011 DOI: https://doi.org/10.1016/j.biopsych.2006.06.011

Ellison-Wright I, Ellison-Wright Z, Bullmore E. Structural brain change in ADHD identified by meta-analysis. BMC Psychiatry. 2008;8:1-8. https://doi.org/10.1186/1471-244X-8-51 DOI: https://doi.org/10.1186/1471-244X-8-51

Nakao T, Radua J, Rubia K, Mataix-Cols D. Gray Matter Volume Abnormalities in ADHD: Voxel-Based Meta-Analysis Exploring the Effects of Age and Stimulant Medication. Am J Psychiatry. 2011;168:1154-63. https://doi.org/10.1176/appi.ajp.2011.11020281 DOI: https://doi.org/10.1176/appi.ajp.2011.11020281

Sowell ER, Thompson PM, Welcome SE, Henkenius AL, Toga AW, Peterson BS. Cortical abnormalities in children and adolescents with attention-deficit hyperactivity disorder. Lancet. 2003;362:1699-707. https://doi.org/10.1016/S0140-6736(03)14842-8 DOI: https://doi.org/10.1016/S0140-6736(03)14842-8

Shaw P, Clasen L, Giedd J, Rapoport J. Longitudinal mapping of cortical thickness and clinical outcome in children and adolescents with attention-eficit/hyperactivity disorder. Arch Gen Psychiatry. 2006;63:540-9. https://doi.org/10.1001/archpsyc.63.5.540 DOI: https://doi.org/10.1001/archpsyc.63.5.540

Wolosin SM, Richardson ME, Hennessey JG, Denckla MB, Mostofsky SH. Abnormal cerebral cortex structure in children with ADHD. Hum Brain Mapp. 2009;30:175-84. https://doi.org/10.1002/hbm.20496 DOI: https://doi.org/10.1002/hbm.20496

Narr KL, Woods RP, Lin J, et al. Widespread cortical thinning is a robust anatomical marker for attention-deficit/ hyperactivity disorder. J Am Acad Child Adolesc Psychiatry. 2009;48:1014-22. https://doi.org/10.1097/CHI.0b013e3181b395c0 DOI: https://doi.org/10.1097/CHI.0b013e3181b395c0

Shaw P, Eckstrand K, Lerch JP, Greenstein D, ClasenL. Attention-deficit/hyperactivity disorder is characterized by a dealy in cortical maturation. PNAS. 2007:1-6.

Shaw P, Gornick M, Lerch J, et al. Polymorphisms of the dopamine D4 receptor, clinical outcome, and cortical structure in attention-deficit/hyperactivity disorder. Arch Gen Psychiatry. 2007;64:921-31. https://doi.org/10.1001/archpsyc.64.8.921 DOI: https://doi.org/10.1001/archpsyc.64.8.921

Ivanov I, Bansal R, Hao X, et al. Morphological abnormalities of the thalamus in youths with attention deficit hyperactivity disorder. Am J Psychiatry. 2010;167:397-408. https://doi.org/10.1176/appi.ajp.2009.09030398 DOI: https://doi.org/10.1176/appi.ajp.2009.09030398

Ashtari M, Kumra S, Bhaskar SL, et al. Attention-deficit/ hyperactivity disorder: a preliminary diffusion tensor imaging study. Biol Psychiatry. 2005;57:448-55. https://doi.org/10.1016/j.biopsych.2004.11.047 DOI: https://doi.org/10.1016/j.biopsych.2004.11.047

Casey BJ, Epstein JN, Buhle J, et al. Frontostriatal connectivity and its role in cognitive control in parent-child dyads with ADHD. Am J Psychiatry. 2007;164:1729-36. https://doi.org/10.1176/appi.ajp.2007.06101754 DOI: https://doi.org/10.1176/appi.ajp.2007.06101754

Hamilton LS, Levitt JG, O'Neill J, et al. Reduced white matter integrity in attention-deficit hyperactivity disorder. Neuroreport. 2008;19:1705-8. https://doi.org/10.1097/WNR.0b013e3283174415 DOI: https://doi.org/10.1097/WNR.0b013e3283174415

Cao Q, Sun L, Gong G, et al. The macrostructural and microstructural abnormalities of corpus callosum in children with attention deficit/hyperactivity disorder: A combined morphometric and diffusion tensor MRI study. Brain Res. 2010;1310:172-180. https://doi.org/10.1016/j.brainres.2009.10.031 DOI: https://doi.org/10.1016/j.brainres.2009.10.031

Kobel M, Bechtel N, Specht K, et al. Structural and functional imaging approaches in attention deficit/hyperactivity disorder: does the temporal lobe play a key role? Psychiatry Res. 2010;183:230-6. https://doi.org/10.1016/j.pscychresns.2010.03.010 DOI: https://doi.org/10.1016/j.pscychresns.2010.03.010

Davenport ND, Karatekin C, White T, Lim KO. Differential fractional anisotropy abnormalities in adolescents with ADHD or schizophrenia. Psychiatry Res. 2010;181:193-8. https://doi.org/10.1016/j.pscychresns.2009.10.012 DOI: https://doi.org/10.1016/j.pscychresns.2009.10.012

Konrad K, Eickhoff SB. Is the ADHD brain wired differently? A review on structural and functional connectivity in attention deficit hyperactivity disorder. Hum Brain Mapp. 2010;31:904-16. https://doi.org/10.1002/hbm.21058 DOI: https://doi.org/10.1002/hbm.21058

Ogawa S, Lee TM, Kay AR, Tank DW. Brain magnetic resonance imaging with contrast dependent on blood oxygenation. Proc Natl Acad Sci USA. 1990;87:9868-72. https://doi.org/10.1073/pnas.87.24.9868 DOI: https://doi.org/10.1073/pnas.87.24.9868

Dickstein SG, Bannon K, Milham MP. The neural correlates of attention deficit hyperactivity disorder: an ALE meta-analysis. J Child Psychol Psychiatry. 2006;47:1051-62. https://doi.org/10.1111/j.1469-7610.2006.01671.x DOI: https://doi.org/10.1111/j.1469-7610.2006.01671.x

Buckner RL, Andrews-Hanna JR, Schacter DL. The brain's default network: anatomy, function, and relevance to disease. Ann N Y Acad Sci. 2008;1124:1-38. https://doi.org/10.1196/annals.1440.011 DOI: https://doi.org/10.1196/annals.1440.011

Sonuga-Barke EJS, Castellanos FX. Spontaneous attentional fluctuations in impaired states and pathologicalconditions: a neurobiological hypothesis. Neurosci Biobehav Rev. 2007;31:977-86. https://doi.org/10.1016/j.neubiorev.2007.02.005 DOI: https://doi.org/10.1016/j.neubiorev.2007.02.005

Lin P, Sun J, Yu G, et al. Global and local brain network reorganization in attention-deficit/hyperactivity disorder. Brain Imaging and Behavior. 2013;11.Epub ahead of print. 25. Fair DA, Posner J, Nagel BJ, et al. Atypical default network connectivity in youth with attention-deficit/hyperactivity disorder. Biol Psychiatry. 2010;68:1084-91. https://doi.org/10.1016/j.biopsych.2010.07.003 DOI: https://doi.org/10.1016/j.biopsych.2010.07.003

Castellanos FX, Margulies DS, Kelly C, et al. Cingulate-precuneus interactions: a new locus of dysfunction in adult attention-deficit/hyperactivity disorder. Biol Psychiatry. 2008;63:332-7. https://doi.org/10.1016/j.biopsych.2007.06.025 DOI: https://doi.org/10.1016/j.biopsych.2007.06.025

Rubia K, Halari R, Mohammad A-M, Taylor E, Brammer M. Methylphenidate normalizes frontocingulate underactivation during error processing in attention-deficit/hyperactivity disorder. Biol Psychiatry. 2011;70:255-62. https://doi.org/10.1016/j.biopsych.2011.04.018 DOI: https://doi.org/10.1016/j.biopsych.2011.04.018

Nooner KB, Colcombe SJ, Tobe RH, et al. The NKIRockland Sample: A Model for Accelerating the Pace of Discovery Science in Psychiatry. Front Neurosci. 2012;6:152. https://doi.org/10.3389/fnins.2012.00152 DOI: https://doi.org/10.3389/fnins.2012.00152

Published

2014-04-30

How to Cite

1.
Picon FA. ADHD neuroimaging: findings from structural and functional magnetic resonance imaging. Debates em Psiquiatria [Internet]. 2014 Apr. 30 [cited 2025 Feb. 5];4(2):36-41. Available from: https://revistardp.org.br/revista/article/view/248

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