Insights into compulsive eating behavior, body image, and inflammation among individuals with schizophrenia

Authors

  • Isabel de Andrade Amato Department of Psychiatry, School of Medical Sciences, State University of Campinas, FCM-UNICAMP, Campinas, SP, Brazil https://orcid.org/0000-0002-4427-8392
  • Renato Oliveira Silva Department of Medical Sciences, School of Medicine of the Mineiro Triangle, FMTM, Uberaba, MG, Brazil https://orcid.org/0009-0008-3174-1377
  • Pedro Gabriel Lorencetti Department of Psychiatry, School of Medical Sciences, State University of Campinas, FCM-UNICAMP, Campinas, SP, Brazil https://orcid.org/0000-0002-3374-8838
  • Sérgio Roberto Correa Vicentin Department of Psychiatry, School of Medical Sciences, State University of Campinas, FCM-UNICAMP, Campinas, SP, Brazil https://orcid.org/0000-0003-3907-7497
  • Thaís Paulino do Prado Laboratory of Cell Signaling, University of Campinas, Brazil. Nursing School, University of Campinas, Campinas, SP, Brazil https://orcid.org/0000-0001-5740-8072
  • Vanessa Cristina Bobbo Laboratory of Cell Signaling, University of Campinas, Brazil. Nursing School, University of Campinas, Campinas, SP, Brazil https://orcid.org/0000-0003-2941-2386
  • Guilherme Augusto da Silva Nogueira Laboratory of Cell Signaling, University of Campinas, SP, Brazil https://orcid.org/0000-0001-8659-6236
  • Eloisa Helena Rubello Valler Celeri Department of Psychiatry, School of Medical Sciences, State University of Campinas, FCM-UNICAMP, Campinas, SP, Brazil
  • Renata Cruz Soares de Azevedo Department of Psychiatry, School of Medical Sciences, State University of Campinas (FCM-UNICAMP), Campinas, SP, Brazil. https://orcid.org/0000-0002-7098-7109
  • Lício Augusto Velloso Laboratory of Cell Signaling, University of Campinas, Campinas, SP, Brazil https://orcid.org/0000-0002-4806-7218
  • Paulo Dalgalarrondo Department of Psychiatry, School of Medical Sciences, State University of Campinas, FCM-UNICAMP, Campinas, SP, Brazil
  • Amilton dos Santos Junior Department of Psychiatry, School of Medical Sciences, State University of Campinas, FCM-UNICAMP, Campinas, SP, Brazil https://orcid.org/0000-0002-4328-4619

DOI:

https://doi.org/10.25118/2763-9037.2023.v13.832

Keywords:

Binge-Eating Disorder, Inflammation, Schizophrenia, Body Dissatisfaction

Abstract

Objective: Binge Eating Disorder (BED) is highly prevalent in individuals with schizophrenia. This study aimed to explore the perception of compulsive eating in patients with schizophrenia and its associations with clinical, psychopathological, and inflammatory markers. Methods: 45 participants with a complaint of binge eating were assessed using the Binge Eating Scale (BES). Clinical and anthropometric assessments were performed, which included body fat measurements, as well as psychopathological dimension measurements using the Positive and Negative Symptom Scale (PANSS). In addition, a body image satisfaction questionnaire based on items from the Body Shape Satisfaction Scale (BSSS) and the Body Shape Questionnaire (BSQ) was administered. Serum inflammatory marker analyses were also conducted, which included the measurement of IL-1β, IL-6, IL-10, TNF-α, and leptin. Results: Spearman correlation tests revealed positive correlations between BES scores, body image dissatisfaction, and PANSS score, as well as a negative correlation with IL-10. Multiple linear regression models showed that BES scores, although not sufficient for the diagnosis of binge eating, were positively associated with body image dissatisfaction score, IL-1β, IL-6 levels (both proinflammatory cytokines), and negatively with IL-10 (an anti-inflammatory cytokine). Conclusion: Our findings suggest that chronic inflammation and psychopathology in individuals with schizophrenia may be associated with impulsive eating behaviors and poorer body image perception. In addition to inflammation, binge eating may contribute to increased cardiovascular mortality and worsening health status of these patients.

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Author Biographies

Isabel de Andrade Amato, Department of Psychiatry, School of Medical Sciences, State University of Campinas, FCM-UNICAMP, Campinas, SP, Brazil

http://lattes.cnpq.br/2510165152556853

Renato Oliveira Silva , Department of Medical Sciences, School of Medicine of the Mineiro Triangle, FMTM, Uberaba, MG, Brazil

http://lattes.cnpq.br/6819200470294837

Pedro Gabriel Lorencetti , Department of Psychiatry, School of Medical Sciences, State University of Campinas, FCM-UNICAMP, Campinas, SP, Brazil

http://lattes.cnpq.br/0558179934502163

Sérgio Roberto Correa Vicentin, Department of Psychiatry, School of Medical Sciences, State University of Campinas, FCM-UNICAMP, Campinas, SP, Brazil

http://lattes.cnpq.br/3041793226766598

Thaís Paulino do Prado, Laboratory of Cell Signaling, University of Campinas, Brazil. Nursing School, University of Campinas, Campinas, SP, Brazil

http://lattes.cnpq.br/3713084059383152

Vanessa Cristina Bobbo, Laboratory of Cell Signaling, University of Campinas, Brazil. Nursing School, University of Campinas, Campinas, SP, Brazil

http://lattes.cnpq.br/5962197320309169

https://orcid.org/0000-0003-2941-2386

Guilherme Augusto da Silva Nogueira, Laboratory of Cell Signaling, University of Campinas, SP, Brazil

http://lattes.cnpq.br/4342514679968307

Eloisa Helena Rubello Valler Celeri, Department of Psychiatry, School of Medical Sciences, State University of Campinas, FCM-UNICAMP, Campinas, SP, Brazil

http://lattes.cnpq.br/3239631273846906

https://orcid.org/0000-0001-9849-9214

Renata Cruz Soares de Azevedo, Department of Psychiatry, School of Medical Sciences, State University of Campinas (FCM-UNICAMP), Campinas, SP, Brazil.

http://lattes.cnpq.br/5231527082445602

Lício Augusto Velloso, Laboratory of Cell Signaling, University of Campinas, Campinas, SP, Brazil

http://lattes.cnpq.br/0009613666274466

Paulo Dalgalarrondo, Department of Psychiatry, School of Medical Sciences, State University of Campinas, FCM-UNICAMP, Campinas, SP, Brazil

http://lattes.cnpq.br/3850243072472292

https://orcid.org/0000-0001-9849-9214

Amilton dos Santos Junior, Department of Psychiatry, School of Medical Sciences, State University of Campinas, FCM-UNICAMP, Campinas, SP, Brazil

http://lattes.cnpq.br/0084146121342864

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2023-12-07

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1.
Amato I de A, Silva RO, Lorencetti PG, Vicentin SRC, Prado TP do, Bobbo VC, et al. Insights into compulsive eating behavior, body image, and inflammation among individuals with schizophrenia. Debates em Psiquiatria [Internet]. 2023 Dec. 7 [cited 2025 Nov. 6];13:1-22. Available from: https://revistardp.org.br/revista/article/view/832

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Vol. 13 (2023)

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Copyright (c) 2023 Isabel de Andrade Amato, Renato Oliveira Silva , Pedro Gabriel Lorencetti , Sérgio Roberto Correa Vicentin, Thaís Paulino do Prado, Vanessa Cristina Bobbo, Guilherme Augusto da Silva Nogueira, Eloisa Helena Rubello Valler Celeri, Renata Cruz Soares de Azevedo, Lício Augusto Velloso, Paulo Dalgalarrondo, Amilton dos Santos Junior

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