Clinical use, misuse and abuse of benzodiazepines: a review
DOI:
https://doi.org/10.25118/2763-9037.2012.v2.880Keywords:
anxiety, treatment, benzodiazepines, drugs dependencyAbstract
Objective: The objective of this review is to critically analyze the use of anxiolytics, their advantages and risks. Method: A bibliographic and historical research was conducted on the evolution of the use of anxiolytics in psychiatry, their misuse, the resulting abuse and the risks of dependence inherent in these situations. Results: The clinical effects of benzodiazepines were contrasted with the current trend of using neurotransmitter reuptake inhibitor antidepressants in anxiety disorders. Conclusion: It is concluded that benzodiazepines continue to be very useful substances in daily clinical practice.
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• 1 – Hetema, , J.H., Neale, M.C. & Kendler, K.S. – A review and meta-analysis of the genetic epidemiology of anxiety disorders – Am.J. Psychiatry 158: 1568-1578, 2001 DOI: https://doi.org/10.1176/appi.ajp.158.10.1568
• 2 – Torgersen, S. – Genetic factors in anxiety disorders – Arch. Of Gen. Psychiatry 40: 1085-1089, 1953 DOI: https://doi.org/10.1001/archpsyc.1983.01790090047007
• 3 – Ban, T. – Psychopharmacology – Williams and Wilkins Co. (Baltimore), 1969, 485 pp
• 4 – Grinker, R. & Spiegel, J.P. – Brief psychotherapies in war neuroses – J. of Psychosomatic Medicine 6: 121- 131, 1944 DOI: https://doi.org/10.1097/00006842-194404000-00002
• 5 – Tobin, J.M., Bird, I.F. & Boyle, D.E. – Preliminary evaluation of Librium (RO 5-0690) in the treatment of anxiety reactions – Dis. Nerv. Syst 31: 11-22, 1960
• 6 - Marks, J. – The benzodiazepines – Use, overuse, misuse, abuse – MTP Press Ltd., Lancaster, England, 1978, 127 pp
• 7 - Bueno, J. R. – Farmacodependências – Uma revisão - J. bras. Psiq.21: 127-136, 1972
• 8 - Findley, J. G., Robinson, W. W, & Peregrino, L. – Addiction of secobarbital and chlordiazepoxide in the Rhesus monkey of self induced preference prodecure - Psychopharmacologia 26: 93-114, 1972 DOI: https://doi.org/10.1007/BF00422097
• 9 -Yanagita, T. & Takahashi, S – Dependence liability of several hypnotic drugs evaluated in monkeys - J.Pharmacol.Exp.Ther. 185: 307-316, 1973
• 10 -Hollister, L. E., Mortzenbecker, F. P. & Degan, R. O. – Withdrawal reactions from chlordiazepoxide (“Librium”) Psychopharmacologia 2: 63- 68, 1961 DOI: https://doi.org/10.1007/BF00429621
• 11 -Hollister, L. E. in The benzodiazepines – Garattini,S., Mussini, E.& O’Randall, L. (eds.) – Raven Press, N.York, 1973 p115
• 12 -Kryspin-Exner, K. & Demel, E. – The use of tranquilizers in the treatment of mixed drug abuse -J.Clin.Pharmacol. Biopharm. 12: 13-18, 1975
• 13 -Cortese, S., Mattos,P. & Bueno, J. R. – Deficits mnêmicos associados ao uso de antidepressores - J.bras.Psiq.47: 343-348, 1998
• 14 -Kaplan & Sadock’s Synopsis in Psychiatry – 7th edition, Kaplan, H. I., Sadock, B.J. & Grebb, J.H. eds. – Wiiliam and Wilkins, 1994, p 911
• 15 -Thase, M.E. –Treatment of anxiety with venlafaxine XR - Expert Review of Neurotherapeuthics 6: 269-282, 2006 DOI: https://doi.org/10.1586/14737175.6.3.269
• 16 -Stahl,S.M., Ahmed, S. & Haudiquet, V. – Analysis of the rate of improvement of specific psychic and somatic symptoms on general anxiety disorders during long-term treatment with venlafaxine XR - CNS Spectrum 12: 703-711, 2007 DOI: https://doi.org/10.1017/S1092852900021544
• 17 -Berney, P., Halperin, D., Tango, R., Daeniker-Dayer, I. & Schulz, P. – Psychopharmacology Bulletin, Sept. 2008
• 18 -Teicher, M. H., Glod, C. & Cole, J.O. – Am.J.Psychiat. 147: 207, 1990 DOI: https://doi.org/10.1176/ajp.147.12.1692
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