Estimulação magnética transcraniana em psiquiatria
DOI:
https://doi.org/10.25118/2763-9037.2012.v2.887Palavras-chave:
Estimulação Magnética Transcraniana, estimulação cerebral, aplicações clínicas, efeitos adversosResumo
Objetivo: O objetivo deste artigo foi retratar a experiência com Estimulação Magnética Transcraniana no Instituto de Psiquiatria do Hospital das Clínicas da Faculdade de Medicina de Medicina USP (HC-FMUSP), e sua aplicação na prática clínica psiquiátrica. Métodos: Foi feita uma descrição geral dos princípios e histórico da Estimulação Magnética Transcraniana (EMT). E ainda, foram compilados os principais resultados de pesquisa por nós realizadas ao longo de 13 anos em áreas como depressão, esquizofrenia, transtorno obsessivo compulsivo, dependência química, comprometimento cognitivo, infância (autismo), entre outros. São abordadas também questões relativas à segurança e efeitos colaterais de importância para a prática clínica. Resultados: São abordados junto com os principais estudos apresentados no corpo do texto. Conclusão: A EMT é um procedimento de múltiplas indicações terapêuticas em transtornos psiquiátricos e neurológicos, além de ter potencial diagnóstico e utilidade no planejamento neurocirúrgico. Atualmente, tem aprovação pelo Conselho Federal de Medicina para tratamento de depressões e alucinações auditivas independentemente de protocolos de pesquisa. É um método inovador em seus aspectos técnicos: não invasivo, estímulo focal e indolor, simples de ser aplicado e com baixo risco para pesquisas em seres humanos, além de perfil benigno de feitos colaterais.
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- George MS, Wassermann EM. Rapid-rate transcranial magnetic stimulation and ECT. Convuls Ther 1994;10:251-254.
- Marcolin MA, Da Costa CA. Estimulação Magnética Transcraniana - Uma propedêutica neurológica e uma terapêutica psiquiátrica. Psiquiatria Biológica, 1999; 7: 69-75.
- Mhalla A, de Andrade DC, Baudic S, Perrot S, Bouhassira D. Alteration of cortical excitability in patients with fibromyalgia. Pain., 2010; 149: 495-500. DOI: https://doi.org/10.1016/j.pain.2010.03.009
- Greenberg BD, Ziemann U, Cora-Locatelli G, Harmon A, Murphy DL, Keel JC, Wassermann EM. Altered cortical excitability in obsessive-compulsive disorder. Neurology. 2000; 54:142-7. DOI: https://doi.org/10.1212/WNL.54.1.142
- Rossi S, Hallett M, Rossini PM, Pascual-Leone A. Safety, ethical considerations, and application guidelines for the use of transcranial magnetic stimulation in clinical practice and research. . Clin Neurophysiol. 2009; 120: 2008-2039. DOI: https://doi.org/10.1016/j.clinph.2009.08.016
- Pascual-Leone A, Valls-Solé J, Brasil-Neto JP, Cohen L, Hallett M. Seizure induction and transcranial magnetic stimulation. Lancet, 1992; 339: 997 DOI: https://doi.org/10.1016/0140-6736(92)91582-S
- Pascual-Leone A, Bartres-Faz D, Keenan JP. Transcranial magnetic stimulation: studying the brain behaviour relationship by inducing “virtual lesions”. Trans R Soc Lond B Biol Sci, 1999; 354: 1229-1238. DOI: https://doi.org/10.1098/rstb.1999.0476
- Romero, J.R.; Anschel, D.; Sparing, R.; Gangitano, M.; Pascual-Leone, A. Subthreshold low frequency repetitive transcranial magnetic stimulation selectively decreases facilitation in the motor cortex. Clin Neurophysiol, 2002,113:101-7. DOI: https://doi.org/10.1016/S1388-2457(01)00693-9
- Dannon PN, Dolberg OT, Schreiber S, Grunhaus L. Three and six-month outcome following courses of either ECT or rTMS in a population of severely depressed individuals--preliminary report. Biol Psychiatry, 2002; 113: 687-90. DOI: https://doi.org/10.1016/S0006-3223(01)01274-4
- Loo CK, Mitchell PB. A review of the efficacy of transcranial magnetic stimulation (TMS) treatment for depression, and current and future strategies to optimize efficacy. Journal of Affective Disorders, 2005;88:255-67 DOI: https://doi.org/10.1016/j.jad.2005.08.001
- Lisanby SH, Datto CJ, Szuba MP. ECT and TMS: past, present, and future. Depress Anxiety, 2000; 12: 115-7. DOI: https://doi.org/10.1002/1520-6394(2000)12:3<115::AID-DA1>3.0.CO;2-M
- Rumi DO, Gattaz WF, Rigonatti SP, Rosa MA, Fregni F, Rosa MO, Mansur C, Myczkowski ML, Moreno RA, Marcolin MA. Transcranial magnetic stimulation accelerates theantidepressant effect of amitriptyline in severe depression: a double-blind placebo-controlled study. Biol Psychiatry, 2005; 57: 162-6. DOI: https://doi.org/10.1016/j.biopsych.2004.10.029
- Pacual-Leone,A.; Rubio, B.; Pallardo, F.; Catala,M.D. Rapid-rate transcranial magnetic stimulation of left dorsolateral pré-frontal cortex in drug-resistant depression. Lancet, 1996; 348: 233-237. DOI: https://doi.org/10.1016/S0140-6736(96)01219-6
- Menkes DL, Bodnar P, Ballesteros RA, Swenson MR. Right frontal lobe slow frequency repetitive transcranial magnetic stimulation (SF r-TMS) is an effective treatment for depression: a case-control pilot study of safety and efficacy. J Neurol Neurosurg Psychiatry, 1999; 67: 113-5. DOI: https://doi.org/10.1136/jnnp.67.1.113
- Demirtas-Tatlidede A, Mechanic-Hamilton D, Press DZ, Pearlman C, Stern WM, Thall M, Pascual-Leone A. An openlabel, prospective study of repetitive transcranial magnetic stimulation (rTMS) in the long-term treatment of refractory depression: reproduce; 69: 930-4. DOI: https://doi.org/10.4088/JCP.v69n0607
- Cohen RB , Boggio PS, Fregni F. Risk factors for relapse after remission with repetitive transcranial magnetic stimulation for the treatment of depression. Depress Anxiety, 2009; 26: 682-8. DOI: https://doi.org/10.1002/da.20486
- Schüle C, Zwanzger P, Baghai T, Mikhaiel P, Thoma H, Möller HJ, Rupprecht R, Padberg F. Effects of antidepressant pharmacotherapy after repetitive transcranial magnetic stimulation in major depression: an open follow-up study. J Psychiatr Res., 2003; 37:145-53. DOI: https://doi.org/10.1016/S0022-3956(02)00101-2
- Nahas Z, Bohning DE, Molloy MA, Oustz JA, Risch SC, George MS. Safety and Feasibility of Repetitive Transcranial Magnetic Stimulation in the Treatment of Anxious Depression in Pregnancy: A Case Report. J Clin Psychiatry. 1999: 50-2. DOI: https://doi.org/10.4088/JCP.v60n0111
- Klirova M, Novak T, Kopecek M, Mohr P, Strunzova V. Repetitive transcranial magnetic stimulation (rTMS) in major depressive episode during pregnancy. Neuro Endocrinol Lett., 2008; 29: 69-70.
- Burt T, Lisanby H, Sackeim H. Neuropsychiatric applications of transcranial magnetic stimulation: a metaanalysis. International Journal of Neuro psychopharmacology, 2002, 5:73–10. DOI: https://doi.org/10.1017/S1461145702002791
- Hoffman RE, Boutros NN, Berman RM, Roessler E, Belger A, Krystal JH, Charney DS. Transcranial magnetic stimulation of left temporoparietal cortex in three patients reporting hallucinated “voices”. Biol Psychiatry, 1999; 1: 130-2. DOI: https://doi.org/10.1016/S0006-3223(98)00358-8
- Mansur CG, Myczkowki ML, de Barros CabralS, Sartorelli M do C, Bellini BB, Dias AM, Bernik MA, Marcolin MA. Placebo effect after prefrontal magnetic stimulation in the treatment of resistant obsessivecompulsive disorder: a randomized controlled trial. Int J Neuropsychopharmacol., 2010; 13:217–227.
- Mantovani A, Simpson HB, Fallon BA, Rossi S, Lisanby SH. Randomized sham-controlled trial of repetitive transcranial magnetic stimulation in treatment-resistant obsessive-compulsive disorder. Int J Neuropsychopharmacol., 2010;13:217–227. DOI: https://doi.org/10.1017/S1461145709990435
- Volkow, N. D., and Li, T. K. “Drug addiction: the neurobiology of behaviour gone awry.” Nature reviews. Neuroscience,2004; 5: 963-70. DOI: https://doi.org/10.1038/nrn1539
- Johann, M., Wiegand, R., Kharraz, A., Bobbe, G., Sommer, G., and Hajak, G. Transcranial Magnetic Stimulation for Nicotine Dependende. Psychiatrr Prax, 2003, 30: 129-S131.
- Politi, E., Fauci, E., Santoro, A., and Smeraldi, E. Daily sessions of Transcranial Magnetic Stimulation to the Left Prefrontal Cortex Gradually reduce Cocaine Craving. American J Addict, 2008, 17:345-6. DOI: https://doi.org/10.1080/10550490802139283
- Mishra, B. R., Nizamie, S. H., Das, B., and Praharaj, S. K. Efficacy of repetitive transcranial magnetic stimulation in alcohol dependence : a sham-controlled study. Addiction, 2010, 105:49-55. DOI: https://doi.org/10.1111/j.1360-0443.2009.02777.x
- Ribeiro PL, Arnaut D, Marra H, Bellini BB, Lancelote CA, Mansur CG, Myczcowski ML, Baltieri DA, Marcolin MA. Poster Presentation at World Biological Association Congress, Prague, 2011. Publications ate the Congress Annals (no annals publishing house available)
- Guse B , Falkai P, Wobrock T. Cognitive effects of highfrequency repetitive transcranial magnetic stimulation: a systematic review. J Neural Transm., 2010; 117:105-22. DOI: https://doi.org/10.1007/s00702-009-0333-7
- Bentwich J, Dobronevsky E, Aichenbaum S, Shorer R, Peretz R, Khaigrekht M, Marton RG, Rabey JM. Beneficial effect of repetitive transcranial magnetic stimulation combined with cognitive training for the treatment of Alzheimer’s disease: a proof of concept study. J Neural Transm., 2011, 118:463–471. DOI: https://doi.org/10.1007/s00702-010-0578-1
- Solé-Padullés C, Bartrés-Faz D, Junqué C, Clemente IC, Molinuevo JL, Bargalló N, Sánchez-Aldeguer J, Bosch B, Falcón C, Valls-Solé J. Repetitive transcranial magnetic stimulation effects on brain function and cognition among elders with memory dysfunction. A randomized sham-controlled study. Cereb Cortex., 2006; 16:1487-93. DOI: https://doi.org/10.1093/cercor/bhj083
- Nardone R, Bergmann J, Christova M, Caleri F, Tezzon F, Ladurner G, Trinka E, Golaszewski S. Effect of Transcranial Brain Stimulation for the treatment of Alzheimer Disease. Int J Alzheimers Dis., 2012; 2012:2-5. DOI: https://doi.org/10.1155/2012/687909
- Rubio-Morell B, Rotenberg A, Hernández-Expósito S, Pascual-Leone Á.The use of noninvasive brain stimulation in childhood psychiatric disorders: new diagnostic and therapeutic opportunities and challenges. Rev Neurol., 2011; 53:209-25. DOI: https://doi.org/10.33588/rn.5304.2011072
- Sokhadze EM, El-Baz A, Baruth J, Mathai G, Sears L, Casanova MF. Effects of Low Frequency Repetitive Transcranial Magnetic Stimulation (rTMS) on Gamma Frequency Oscillations and Event-Related Potentials During Processing of Illusory Figures in Autism. J Autism Dev Disord., 2009; 39: 619-34 DOI: https://doi.org/10.1007/s10803-008-0662-7
- Sokhadze EM, Baruth JM, Sears L, Sokhadze GE, El-Baz AS, Casanova MF. Prefrontal Neuromodulation Using rTMS Improves Error Monitoring and Correction Function in Autism. Appl Psychophysiol Biofeedback., 2012; 37:91-102. DOI: https://doi.org/10.1007/s10484-012-9182-5
- Wassermann EM. Risk and Safety of Repetitive Transcranial Magnetic Stimulation: Report and Suggested Guidelines from the International Worksop on the Safety of rTMS. Electroencephalogr Clin Neurophysiol,, 1998; 108:1-16. DOI: https://doi.org/10.1016/S0168-5597(97)00096-8
- Karlström EF, Lundström R, Stensson O, Mild KH.Therapeutic staff exposure to magnetic field pulses during TMS/rTMS treatments. Bioelectromagnetics, 2006; 27:156-8.10 -Hollister, L. E., Mortzenbecker, F. P. & Degan, R. O. – Withdrawal reactions from chlordiazepoxide (“Librium”) Psychopharmacologia 2: 63- 68, 1961 DOI: https://doi.org/10.1002/bem.20194
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Copyright (c) 2012 Marco Antonio Marcolin, Hellen Livia Drumond Marra, Caio Abujadi, Carlos Gustavo Sardinha Mansur, Martin Luiz Myczkowski, Philip Leite Ribeiro, Rodrigo Lancelote Alberto, Bianca Boura Bellini
Este trabalho está licenciado sob uma licença Creative Commons Attribution-NonCommercial 4.0 International License.
Debates em Psiquiatria permite que o (s) autor (es) mantenha(m) seus direitos autorais sem restrições. Atribuição-NãoComercial 4.0 Internacional (CC BY-NC 4.0) - Debates em Psiquiatria é regida pela licença CC-BY-NC
