Transcranial magnetic stimulation in psychiatry

Authors

  • Marco Antonio Marcolin Transcranial Magnetic Stimulation Nucleus, Instituto de Psiquiatria, Hospital das Clínicas da Faculdade de Medicina USP, São Paulo (SP), Brazil
  • Hellen Livia Drumond Marra Transcranial Magnetic Stimulation Nucleus, Instituto de Psiquiatria, Hospital das Clínicas da Faculdade de Medicina USP, São Paulo (SP), Brazil
  • Caio Abujadi Transcranial Magnetic Stimulation Nucleus, Instituto de Psiquiatria, Hospital das Clínicas da Faculdade de Medicina USP, São Paulo (SP), Brazil
  • Carlos Gustavo Sardinha Mansur Transcranial Magnetic Stimulation Nucleus, Instituto de Psiquiatria, Hospital das Clínicas da Faculdade de Medicina USP, São Paulo (SP), Brazil
  • Martin Luiz Myczkowski Transcranial Magnetic Stimulation Nucleus, Instituto de Psiquiatria, Hospital das Clínicas da Faculdade de Medicina USP, São Paulo (SP), Brazil
  • Philip Leite Ribeiro Transcranial Magnetic Stimulation Nucleus, Instituto de Psiquiatria, Hospital das Clínicas da Faculdade de Medicina USP, São Paulo (SP), Brazil
  • Rodrigo Lancelote Alberto Transcranial Magnetic Stimulation Nucleus, Instituto de Psiquiatria, Hospital das Clínicas da Faculdade de Medicina USP, São Paulo (SP), Brazil
  • Bianca Boura Bellini Transcranial Magnetic Stimulation Nucleus, Instituto de Psiquiatria, Hospital das Clínicas da Faculdade de Medicina USP, São Paulo (SP), Brazil

DOI:

https://doi.org/10.25118/2763-9037.2012.v2.887

Keywords:

transcranial magnetic stimulation, brain stimulation, clinical applications, adverse effects

Abstract

Objective: The objective of this article was to describe the experience with Transcranial Magnetic Stimulation at the Institute of Psychiatry of the Hospital das Clínicas of the Medical School of the University of São Paulo (HC-FMUSP), and its application in psychiatric clinical practice. Methods: A general description of the principles and history of Transcranial Magnetic Stimulation (TMS) was provided. Furthermore, the main results of research conducted by us over 13 years in areas such as depression, schizophrenia, obsessive-compulsive disorder, chemical dependency, cognitive impairment, childhood (autism), among others, were compiled. Issues related to safety and side effects of importance for clinical practice are also addressed. Results: These are addressed together with the main studies presented in the body of the text. Conclusion: TMS is a procedure with multiple therapeutic indications in psychiatric and neurological disorders, in addition to having diagnostic potential and usefulness in neurosurgical planning. It is currently approved by the Federal Council of Medicine for the treatment of depression and auditory hallucinations, regardless of research protocols. It is an innovative method in its technical aspects: non-invasive, focal and painless stimulation, simple to apply and with low risk for research in human beings, in addition to a benign profile of side effects.

Downloads

Download data is not yet available.

Metrics

Metrics Loading ...

Author Biographies

Marco Antonio Marcolin, Transcranial Magnetic Stimulation Nucleus, Instituto de Psiquiatria, Hospital das Clínicas da Faculdade de Medicina USP, São Paulo (SP), Brazil

Hellen Livia Drumond Marra, Transcranial Magnetic Stimulation Nucleus, Instituto de Psiquiatria, Hospital das Clínicas da Faculdade de Medicina USP, São Paulo (SP), Brazil

Caio Abujadi, Transcranial Magnetic Stimulation Nucleus, Instituto de Psiquiatria, Hospital das Clínicas da Faculdade de Medicina USP, São Paulo (SP), Brazil

Carlos Gustavo Sardinha Mansur, Transcranial Magnetic Stimulation Nucleus, Instituto de Psiquiatria, Hospital das Clínicas da Faculdade de Medicina USP, São Paulo (SP), Brazil

Martin Luiz Myczkowski, Transcranial Magnetic Stimulation Nucleus, Instituto de Psiquiatria, Hospital das Clínicas da Faculdade de Medicina USP, São Paulo (SP), Brazil

Philip Leite Ribeiro, Transcranial Magnetic Stimulation Nucleus, Instituto de Psiquiatria, Hospital das Clínicas da Faculdade de Medicina USP, São Paulo (SP), Brazil

Rodrigo Lancelote Alberto, Transcranial Magnetic Stimulation Nucleus, Instituto de Psiquiatria, Hospital das Clínicas da Faculdade de Medicina USP, São Paulo (SP), Brazil

Bianca Boura Bellini, Transcranial Magnetic Stimulation Nucleus, Instituto de Psiquiatria, Hospital das Clínicas da Faculdade de Medicina USP, São Paulo (SP), Brazil

References

- George MS, Wassermann EM. Rapid-rate transcranial magnetic stimulation and ECT. Convuls Ther 1994;10:251-254.

- Marcolin MA, Da Costa CA. Estimulação Magnética Transcraniana - Uma propedêutica neurológica e uma terapêutica psiquiátrica. Psiquiatria Biológica, 1999; 7: 69-75.

- Mhalla A, de Andrade DC, Baudic S, Perrot S, Bouhassira D. Alteration of cortical excitability in patients with fibromyalgia. Pain., 2010; 149: 495-500. DOI: https://doi.org/10.1016/j.pain.2010.03.009

- Greenberg BD, Ziemann U, Cora-Locatelli G, Harmon A, Murphy DL, Keel JC, Wassermann EM. Altered cortical excitability in obsessive-compulsive disorder. Neurology. 2000; 54:142-7. DOI: https://doi.org/10.1212/WNL.54.1.142

- Rossi S, Hallett M, Rossini PM, Pascual-Leone A. Safety, ethical considerations, and application guidelines for the use of transcranial magnetic stimulation in clinical practice and research. . Clin Neurophysiol. 2009; 120: 2008-2039. DOI: https://doi.org/10.1016/j.clinph.2009.08.016

- Pascual-Leone A, Valls-Solé J, Brasil-Neto JP, Cohen L, Hallett M. Seizure induction and transcranial magnetic stimulation. Lancet, 1992; 339: 997 DOI: https://doi.org/10.1016/0140-6736(92)91582-S

- Pascual-Leone A, Bartres-Faz D, Keenan JP. Transcranial magnetic stimulation: studying the brain behaviour relationship by inducing “virtual lesions”. Trans R Soc Lond B Biol Sci, 1999; 354: 1229-1238. DOI: https://doi.org/10.1098/rstb.1999.0476

- Romero, J.R.; Anschel, D.; Sparing, R.; Gangitano, M.; Pascual-Leone, A. Subthreshold low frequency repetitive transcranial magnetic stimulation selectively decreases facilitation in the motor cortex. Clin Neurophysiol, 2002,113:101-7. DOI: https://doi.org/10.1016/S1388-2457(01)00693-9

- Dannon PN, Dolberg OT, Schreiber S, Grunhaus L. Three and six-month outcome following courses of either ECT or rTMS in a population of severely depressed individuals--preliminary report. Biol Psychiatry, 2002; 113: 687-90. DOI: https://doi.org/10.1016/S0006-3223(01)01274-4

- Loo CK, Mitchell PB. A review of the efficacy of transcranial magnetic stimulation (TMS) treatment for depression, and current and future strategies to optimize efficacy. Journal of Affective Disorders, 2005;88:255-67 DOI: https://doi.org/10.1016/j.jad.2005.08.001

- Lisanby SH, Datto CJ, Szuba MP. ECT and TMS: past, present, and future. Depress Anxiety, 2000; 12: 115-7. DOI: https://doi.org/10.1002/1520-6394(2000)12:3<115::AID-DA1>3.0.CO;2-M

- Rumi DO, Gattaz WF, Rigonatti SP, Rosa MA, Fregni F, Rosa MO, Mansur C, Myczkowski ML, Moreno RA, Marcolin MA. Transcranial magnetic stimulation accelerates theantidepressant effect of amitriptyline in severe depression: a double-blind placebo-controlled study. Biol Psychiatry, 2005; 57: 162-6. DOI: https://doi.org/10.1016/j.biopsych.2004.10.029

- Pacual-Leone,A.; Rubio, B.; Pallardo, F.; Catala,M.D. Rapid-rate transcranial magnetic stimulation of left dorsolateral pré-frontal cortex in drug-resistant depression. Lancet, 1996; 348: 233-237. DOI: https://doi.org/10.1016/S0140-6736(96)01219-6

- Menkes DL, Bodnar P, Ballesteros RA, Swenson MR. Right frontal lobe slow frequency repetitive transcranial magnetic stimulation (SF r-TMS) is an effective treatment for depression: a case-control pilot study of safety and efficacy. J Neurol Neurosurg Psychiatry, 1999; 67: 113-5. DOI: https://doi.org/10.1136/jnnp.67.1.113

- Demirtas-Tatlidede A, Mechanic-Hamilton D, Press DZ, Pearlman C, Stern WM, Thall M, Pascual-Leone A. An openlabel, prospective study of repetitive transcranial magnetic stimulation (rTMS) in the long-term treatment of refractory depression: reproduce; 69: 930-4. DOI: https://doi.org/10.4088/JCP.v69n0607

- Cohen RB , Boggio PS, Fregni F. Risk factors for relapse after remission with repetitive transcranial magnetic stimulation for the treatment of depression. Depress Anxiety, 2009; 26: 682-8. DOI: https://doi.org/10.1002/da.20486

- Schüle C, Zwanzger P, Baghai T, Mikhaiel P, Thoma H, Möller HJ, Rupprecht R, Padberg F. Effects of antidepressant pharmacotherapy after repetitive transcranial magnetic stimulation in major depression: an open follow-up study. J Psychiatr Res., 2003; 37:145-53. DOI: https://doi.org/10.1016/S0022-3956(02)00101-2

- Nahas Z, Bohning DE, Molloy MA, Oustz JA, Risch SC, George MS. Safety and Feasibility of Repetitive Transcranial Magnetic Stimulation in the Treatment of Anxious Depression in Pregnancy: A Case Report. J Clin Psychiatry. 1999: 50-2. DOI: https://doi.org/10.4088/JCP.v60n0111

- Klirova M, Novak T, Kopecek M, Mohr P, Strunzova V. Repetitive transcranial magnetic stimulation (rTMS) in major depressive episode during pregnancy. Neuro Endocrinol Lett., 2008; 29: 69-70.

- Burt T, Lisanby H, Sackeim H. Neuropsychiatric applications of transcranial magnetic stimulation: a metaanalysis. International Journal of Neuro psychopharmacology, 2002, 5:73–10. DOI: https://doi.org/10.1017/S1461145702002791

- Hoffman RE, Boutros NN, Berman RM, Roessler E, Belger A, Krystal JH, Charney DS. Transcranial magnetic stimulation of left temporoparietal cortex in three patients reporting hallucinated “voices”. Biol Psychiatry, 1999; 1: 130-2. DOI: https://doi.org/10.1016/S0006-3223(98)00358-8

- Mansur CG, Myczkowki ML, de Barros CabralS, Sartorelli M do C, Bellini BB, Dias AM, Bernik MA, Marcolin MA. Placebo effect after prefrontal magnetic stimulation in the treatment of resistant obsessivecompulsive disorder: a randomized controlled trial. Int J Neuropsychopharmacol., 2010; 13:217–227.

- Mantovani A, Simpson HB, Fallon BA, Rossi S, Lisanby SH. Randomized sham-controlled trial of repetitive transcranial magnetic stimulation in treatment-resistant obsessive-compulsive disorder. Int J Neuropsychopharmacol., 2010;13:217–227. DOI: https://doi.org/10.1017/S1461145709990435

- Volkow, N. D., and Li, T. K. “Drug addiction: the neurobiology of behaviour gone awry.” Nature reviews. Neuroscience,2004; 5: 963-70. DOI: https://doi.org/10.1038/nrn1539

- Johann, M., Wiegand, R., Kharraz, A., Bobbe, G., Sommer, G., and Hajak, G. Transcranial Magnetic Stimulation for Nicotine Dependende. Psychiatrr Prax, 2003, 30: 129-S131.

- Politi, E., Fauci, E., Santoro, A., and Smeraldi, E. Daily sessions of Transcranial Magnetic Stimulation to the Left Prefrontal Cortex Gradually reduce Cocaine Craving. American J Addict, 2008, 17:345-6. DOI: https://doi.org/10.1080/10550490802139283

- Mishra, B. R., Nizamie, S. H., Das, B., and Praharaj, S. K. Efficacy of repetitive transcranial magnetic stimulation in alcohol dependence : a sham-controlled study. Addiction, 2010, 105:49-55. DOI: https://doi.org/10.1111/j.1360-0443.2009.02777.x

- Ribeiro PL, Arnaut D, Marra H, Bellini BB, Lancelote CA, Mansur CG, Myczcowski ML, Baltieri DA, Marcolin MA. Poster Presentation at World Biological Association Congress, Prague, 2011. Publications ate the Congress Annals (no annals publishing house available)

- Guse B , Falkai P, Wobrock T. Cognitive effects of highfrequency repetitive transcranial magnetic stimulation: a systematic review. J Neural Transm., 2010; 117:105-22. DOI: https://doi.org/10.1007/s00702-009-0333-7

- Bentwich J, Dobronevsky E, Aichenbaum S, Shorer R, Peretz R, Khaigrekht M, Marton RG, Rabey JM. Beneficial effect of repetitive transcranial magnetic stimulation combined with cognitive training for the treatment of Alzheimer’s disease: a proof of concept study. J Neural Transm., 2011, 118:463–471. DOI: https://doi.org/10.1007/s00702-010-0578-1

- Solé-Padullés C, Bartrés-Faz D, Junqué C, Clemente IC, Molinuevo JL, Bargalló N, Sánchez-Aldeguer J, Bosch B, Falcón C, Valls-Solé J. Repetitive transcranial magnetic stimulation effects on brain function and cognition among elders with memory dysfunction. A randomized sham-controlled study. Cereb Cortex., 2006; 16:1487-93. DOI: https://doi.org/10.1093/cercor/bhj083

- Nardone R, Bergmann J, Christova M, Caleri F, Tezzon F, Ladurner G, Trinka E, Golaszewski S. Effect of Transcranial Brain Stimulation for the treatment of Alzheimer Disease. Int J Alzheimers Dis., 2012; 2012:2-5. DOI: https://doi.org/10.1155/2012/687909

- Rubio-Morell B, Rotenberg A, Hernández-Expósito S, Pascual-Leone Á.The use of noninvasive brain stimulation in childhood psychiatric disorders: new diagnostic and therapeutic opportunities and challenges. Rev Neurol., 2011; 53:209-25. DOI: https://doi.org/10.33588/rn.5304.2011072

- Sokhadze EM, El-Baz A, Baruth J, Mathai G, Sears L, Casanova MF. Effects of Low Frequency Repetitive Transcranial Magnetic Stimulation (rTMS) on Gamma Frequency Oscillations and Event-Related Potentials During Processing of Illusory Figures in Autism. J Autism Dev Disord., 2009; 39: 619-34 DOI: https://doi.org/10.1007/s10803-008-0662-7

- Sokhadze EM, Baruth JM, Sears L, Sokhadze GE, El-Baz AS, Casanova MF. Prefrontal Neuromodulation Using rTMS Improves Error Monitoring and Correction Function in Autism. Appl Psychophysiol Biofeedback., 2012; 37:91-102. DOI: https://doi.org/10.1007/s10484-012-9182-5

- Wassermann EM. Risk and Safety of Repetitive Transcranial Magnetic Stimulation: Report and Suggested Guidelines from the International Worksop on the Safety of rTMS. Electroencephalogr Clin Neurophysiol,, 1998; 108:1-16. DOI: https://doi.org/10.1016/S0168-5597(97)00096-8

- Karlström EF, Lundström R, Stensson O, Mild KH.Therapeutic staff exposure to magnetic field pulses during TMS/rTMS treatments. Bioelectromagnetics, 2006; 27:156-8.10 -Hollister, L. E., Mortzenbecker, F. P. & Degan, R. O. – Withdrawal reactions from chlordiazepoxide (“Librium”) Psychopharmacologia 2: 63- 68, 1961 DOI: https://doi.org/10.1002/bem.20194

Published

2012-08-31

How to Cite

1.
Marcolin MA, Marra HLD, Abujadi C, Mansur CGS, Myczkowski ML, Ribeiro PL, Alberto RL, Bellini BB. Transcranial magnetic stimulation in psychiatry. Debates em Psiquiatria [Internet]. 2012 Aug. 31 [cited 2024 Dec. 18];2(4):6-13. Available from: https://revistardp.org.br/revista/article/view/887

Conference Proceedings Volume

Section

Original Articles

Plaudit