Impacto da obesidade na função imune e transtorno depressivo: revisão integrativa

Autores

DOI:

https://doi.org/10.25118/2763-9037.2023.v13.631

Palavras-chave:

transtorno depressivo, sistema imunitário, obesidade, inflamação, citocinas

Resumo

Objetivo: Esta revisão integrativa tem como objetivo pesquisar e analisar evidências científicas sobre a relação entre a obesidade, a função imune e o transtorno depressivo. Métodos: O presente estudo é uma revisão descritiva da literatura referente às palavras-chave: obesidade, depressão, imunológico, inflamação, psiconeuroimunologia e citocinas.  Os critérios de inclusão foram: artigos publicados em inglês; artigos referentes à revisão integrativa e artigos publicados e indexados no banco de dados PubMed nos últimos 17 anos. Resultados: Uma grande quantidade de evidências indica que a função imunológica parece estar comprometida na obesidade e possui, através desta, relação com desencadeamentos de sintomas depressivos. Entretanto, ainda são necessárias mais evidências para melhor elucidação dos componentes fisiológicos de etiologia das incidências depressivas através da obesidade e das alterações imunológicas associadas. Conclusões: O cenário fisiopatológico da obesidade está intimamente relacionado a alterações na função imunológica e estas podem promover desencadeamentos de sintomatologias depressivas através de mecanismos fisiológicos diversos e desta forma impactar negativamente o estado de saúde mental. 

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Biografia do Autor

Tainá Patrícia Teixeira Bezerra, Graduanda, Nutrição, Universidade Federal da Paraíba, UFPB, João Pessoa, PB, Brasil

Graduanda em Nutrição pela Universidade Federal da Paraíba. Linhas de pesquisa na iniciação científica com foco em neurociência do comportamento alimentar, neuropsiquiatria x variáveis  fisiológicas e alterações de variabilidade de frequência cardíaca em desfechos clinícos diversos.

Roberto Mendes dos Santos , Psiquiatra, Universidade Federal da Paraíba, UFPB, João Pessoa, PB, Brasil

Alfredo José Minervino, Psiquiatra, Universidade Federal da Paraíba, UFPB, João Pessoa, PB, Brasil

Naiara Naiana Dejani, Docente, Universidade Federal da Paraíba, UFPB, João Pessoa, PB, Brasil

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Publicado

2023-06-22

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1.
Bezerra TPT, Santos RM dos, Minervino AJ, Dejani NN. Impacto da obesidade na função imune e transtorno depressivo: revisão integrativa. Debates em Psiquiatria [Internet]. 22º de junho de 2023 [citado 13º de julho de 2024];13:1-18. Disponível em: https://revistardp.org.br/revista/article/view/631

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