Impacto da obesidade na função imune e transtorno depressivo: revisão integrativa
DOI:
https://doi.org/10.25118/2763-9037.2023.v13.631Palavras-chave:
transtorno depressivo, sistema imunitário, obesidade, inflamação, citocinasResumo
Objetivo: Esta revisão integrativa tem como objetivo pesquisar e analisar evidências científicas sobre a relação entre a obesidade, a função imune e o transtorno depressivo. Métodos: O presente estudo é uma revisão descritiva da literatura referente às palavras-chave: obesidade, depressão, imunológico, inflamação, psiconeuroimunologia e citocinas. Os critérios de inclusão foram: artigos publicados em inglês; artigos referentes à revisão integrativa e artigos publicados e indexados no banco de dados PubMed nos últimos 17 anos. Resultados: Uma grande quantidade de evidências indica que a função imunológica parece estar comprometida na obesidade e possui, através desta, relação com desencadeamentos de sintomas depressivos. Entretanto, ainda são necessárias mais evidências para melhor elucidação dos componentes fisiológicos de etiologia das incidências depressivas através da obesidade e das alterações imunológicas associadas. Conclusões: O cenário fisiopatológico da obesidade está intimamente relacionado a alterações na função imunológica e estas podem promover desencadeamentos de sintomatologias depressivas através de mecanismos fisiológicos diversos e desta forma impactar negativamente o estado de saúde mental.
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Copyright (c) 2023 Tainá Patrícia Teixeira Bezerra, Roberto Mendes dos Santos , Alfredo José Minervino, Naiara Naiana Dejani
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