Impacto de la obesidad en la función inmunitaria y el trastorno depresivo: revisión integradora
DOI:
https://doi.org/10.25118/2763-9037.2023.v13.631Palabras clave:
trastorno depresivo, sistema inmunológico, obesidad, inflamación, citocinasResumen
Objectivo: Esta revisión integradora tiene como objetivo buscar y analizar la evidencia científica sobre la relación entre obesidad, función inmune y trastorno depresivo. Métodos: El presente estudio es una revisión descriptiva de la literatura relativa a las palabras clave: obesidad, depresión, inmunológico, inflamación, psiconeuroinmunología y citocinas. Los critérios de inclusion fueron: artículos publicados en inglés; artículos referentes a la revisión integrativa y artículos publicados e indexados en la base de datos PubMed en los últimos 17 años. Resultados: Una gran cantidad de pruebas indica que la función inmunitaria parece estar comprometida en la obesidad y está relacionada con los síntomas depresivos. Sin embargo, aún se necesitan más pruebas para dilucidar mejor los componentes fisiológicos de la etiología de las incidencias depresivas a través de la obesidad y las alteraciones inmunológicas asociadas. Conclusiones: El escenario fisiopatológico de la obesidad está estrechamente relacionado con los cambios en la función inmunitaria y éstos pueden promover el desencadenamiento de síntomas depresivos a través de diversos mecanismos fisiológicos y, por tanto, repercutir negativamente en el estado de salud mental.
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Derechos de autor 2023 Tainá Patrícia Teixeira Bezerra, Roberto Mendes dos Santos , Alfredo José Minervino, Naiara Naiana Dejani
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