Prodromal and at-risk states for bipolar disorder: opportunities for prevention
DOI:
https://doi.org/10.25118/2236-918X-6-5-4Keywords:
Bipolar, mania, prodrome, early stagesAbstract
Bipolar disorder (BD) is a chronic, potentially severe psychiatric illness. In recent years, research focusing on the prodromal and early stages of BD have shown that early detection and intervention strategies have the potential to delay, reduce the severity, or even prevent full episodes of mania. According to this view, a new pathway presents for the clinical management of mood disorders, including not only concern with the treatment of manic and depressive episodes, but also seeking the early detection and diagnosis, andfundamentally, the prevention of BD. The purpose of this article is to discuss data available in the literature on the early stages of BD, the challenges involved in early detection, and the implications that this approach may have for interventions and clinical management before or after the development of the first episode of mania, which is the established marker for the beginning of the disease.
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Post RM, Denicoff KD, Leverich GS, Altshuler LL, Frye MA, Suppes TM, et al. Morbidity in 258 bipolar outpatients followed for 1 year with daily prospective ratings on the NIMH life chart method. J Clin Psychiatry. 2003;64:680-90; quiz 738-9.
Murray CJ, Lopez AD. The global burden of disease: a comprehensive assessment of mortality and disability from diseases, injuries, and risk factors in 1990 and projected to 2020. Cambridge: Harvard University; 1996.
Kapczinski F, Vieta E, Andreazza AC, Frey BN, Gomes FA, Tramontina J, et al. Allostatic load in bipolar disorder: implications for pathophysiology and treatment. Neurosci Biobehav Rev. 2008;32:675-92.
Berk M, Conus P, Lucas N, Hallam K, Malhi GS, Dodd S, et al. Setting the stage: from prodrome to treatment resistance in bipolar disorder. Bipolar Disord. 2007;9:671-8.
Kapczinski F, Dias VV, Kauer-Sant’Anna M, Frey BN, Grassi-Oliveira R, Colom F, et al. Clinical implications of a staging model for bipolar disorders. Expert Rev Neurother. 2009;9:957-66.
Berk M, Hallam KT, McGorry PD. The potential utility of a staging model as a course specifier: a bipolar disorder perspective. J Affect Disord. 2007;100:279-81.
Berk M, Kapczinski F, Andreazza AC, Dean OM, Giorlando F, Maes M, et al. Pathways underlying neuroprogression in bipolar disorder: focus on inflammation, oxidative stress and neurotrophic factors. Neurosci Biobehav Rev. 2011;35:804-17.
Brietzke E, Mansur RB, Soczynska JK, Kapczinski F, Bressan RA, McIntyre RS. Towards a multifactorial approach for prediction of bipolar disorder in at risk populations. J Affect Disord. 2012;140:82-91.
McGorry PD, Yung AR. Early intervention in psychosis: an overdue reform. Aust N Z J Psychiatry. 2003;37:393-8.
McGorry PD, Hickie IB, Yung AR, Pantelis C, Jackson HJ. Clinical staging of psychiatric disorders: a heuristic framework for choosing earlier, safer and more effective interventions. Aust N Z J Psychiatry. 2006;40:616-22.
Taylor M, Bressan RA, Pan Neto P, Brietzke E. Early intervention for bipolar disorder: current imperatives, future directions. Rev Bras Psiquiatr. 2011;33:s197-212.
Bechdolf A, Ratheesh A, Wood SJ, Tecic T, Conus P, Nelson B, et al. Rationale and first results of developing at-risk (prodromal) criteria for bipolar disorder. Curr Pharm Des. 2012;18:358-75.
Singh MK. Is there validity to the bipolar prodrome? J Clin Psychiatry. 2015;76:e655-6.
Rios AC, Noto MN, Rizzo LB, Mansur R, Martins FE Jr, Grassi-Oliveira R, et al. Early stages of bipolar disorder: characterization and strategies for early intervention. Rev Bras Psiquiatr. 2015;37:343-9.
Passos IC, Jansen K, Kapczinski F. Developmental staging models in bipolar disorder. Int J Bipolar Disord. 2015;3:33.
Scott J. Bipolar disorder: from early identification to personalized treatment. Early Interv Psychiatry. 2011;5:89-90.
Correll CU, Hauser M, Penzner JB, Auther AM, Kafantaris V, Saito E, et al. Type and duration of subsyndromal symptoms
in youth with bipolar I disorder prior to their first manic episode. Bipolar Disord. 2014;16:478-92.
Goetz M, Novak T, Vesela M, Hlavka Z, Brunovsky M, Povazan M, et al. Early stages of pediatricbipolar disorder: retrospecti ve analysis of a Czech inpati ent sample. Neuropsychiatr Dis Treat. 2015;11:2855-64.
Noto MN, Noto C, Caribe AC, Miranda-Scippa Â, Nunes SO, Chaves AC, et al. Clinical characteristi cs and infl uence of childhood trauma on the prodrome of bipolar disorder. Rev Bras Psiquiatr. 2015;37:280-8.
Bellivier F, Golmard JL, Rietschel M, Schulze TG, Malafosse A, Preisig M, et al. Age at onset in bipolar I aff ecti ve disorder: further evidence for three subgroups. Am J Psychiatry. 2003;160:999-1001.
Kessler RC, Berglund P, Demler O, Jin R, Koretz D, Merikangas KR, et al. The epidemiology of major depressive disorder: results from the Nati onal Comorbidity Survey Replicati on (NCS-R). JAMA. 2003;289:3095-105.
Egeland JA, Hostett er AM, Pauls DL, Sussex JN. Prodromal symptoms before onset of manicdepressive disorder suggested by fi rst hospital admission histories. J Am Acad Child Adolesc Psychiatry. 2000;39:1245-52.
Fergus EL, Miller RB, Luckenbaugh DA, Leverich GS, Findling RL, Speer AM, et al. Is there progression from irritability/dyscontrol to major depressive and manic symptoms? A retrospecti ve community survey of parents of bipolar children. J Aff ect Disord. 2003;77:71-8.
Rucklidge JJ. Retrospecti ve parent report of psychiatric histories: do checklists reveal specifi c prodromal indicators for postpubertalonset pediatric bipolar disorder? Bipolar Disord. 2008;10:56-66.
Skjelstad DV, Malt UF, Holte A. Symptoms and signs of the initi al prodrome of bipolar disorder: a systemati c review. J Aff ect Disord. 2010;126:1-13.
Birmaher B, Axelson D, Goldstein B, Strober M, Gill MK, Hunt J, et al. Four-year longitudinal course of children and adolescents with bipolar spectrum disorders: the Course and Outcome of Bipolar Youth (COBY) study. Am J Psychiatry. 2009;166:795-804.
Bechdolf A, Nelson B, Cott on SM, Chanen A, Thompson A, Kett le J, et al. A preliminary evaluati on of the validity of at-risk criteria for bipolar disorders in help-seeking adolescents and young adults. J Aff ect Disord. 2010;127:316-20.
Bechdolf A, Ratheesh A, Cott on SM, Nelson B, Chanen AM, Bett s J, et al. The predicti ve validity of bipolar at-risk (prodromal) criteria in help-seeking adolescents and young adults: a prospecti ve study. Bipolar Disord. 2014;16:493-504.
McNamara RK, Strawn JR, Chang KD, DelBello MP. Interventi ons for youth at high risk for bipolar disorder and schizophrenia. Child Adolesc Psychiatr Clin N Am. 2012;21:739-51.
Bauer M, Juckel G, Correll CU, Leopold K, Pfennig A. Diagnosis and treatment in the early illness phase of bipolar disorders. Eur Arch Psychiatry Clin Neurosci. 2008;258:50-4.
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