Relação do transtorno de humor bipolar com o fator neurotrófico derivado do cérebro (BDNF) e alterações moleculares

Suyan Gehlm Ribeiro dos Santos; Carla Streit

doi:10.25118/2236-918X-4-2-2

Autores/as

Suyan Gehlm Ribeiro dos Santos Acadêmica do Curso de Biomedicina do Centro Universitário Metodista, IPA.
Carla Streit Bióloga, Mestre e Doutora em Bioquímica, Psicóloga especialista em Terapia Cognitiva Comportamental e Professora do Curso de Biomedicina e Biologia do Centro Universitário Metodista, IPA. Professora Doutora do Centro Universitário Metodista, IPA.

DOI:

https://doi.org/10.25118/2236-918X-4-2-2

Palabras clave:

Transtorno de Humor Bipolar, Fator Neurotrófico Derivado do Cérebro (BDNF), Alterações Genéticas, Polimorfismos

Resumen

O Transtorno de Humor Bipolar (THB) é uma doença psiquiátrica crônica caracterizada por oscilações ou mudanças cíclicas de humor. Classificado em Tipo I (predomínio de episódios maníacos) forma mais severa da doença e o Tipo II (predomínio de episódios hipomaníacos). Possui origem multifatorial, incluindo influências ambientais, biológicas e genéticas acometendo cerca de 1% a 2 % da população geral. O objetivo deste estudo foi realizar uma revisão da literatura nas bases de dados eletrônicos abordando o transtorno de humor bipolar com o papel do Fator Neurotrófico Derivado do Cérebro (BDNF) e alterações moleculares. Devido ao elevado índice de pacientes acometidos e as diversas hipóteses estudadas por pesquisadores para elucidar os mecanismos envolvidos na doença, este estudo faz-se necessário a fim de contribuir na compreensão da mesma. Conclui-se, que embora haja diversos estudos relacionando polimorfismos à predisposição do THB a fisiopatologia da doença ainda não foi elucidada completamente, necessitando de pesquisas adicionais com o intuito de auxiliar na compreensão e progressão da mesma.

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Czepielewski L, Fillho LD, Brietzke E, Grassi-Oliveira R. Bipolar disorder and metabolic syndrome: a systematic review. Rev Bras Psiquiatr. 2013; 35:88-93

World Health Organization Who. The ICD10 classification of mental and behavioural disorders: clinical descriptions and diagnostic guidelines. Geneva, 2010.

Diagnostic and statistical manual of mental disorders DSM-IV, A.P.A. Washington, DC. 2000

APA: Associação Americana de Psicologia [acessado em 07.05.2013]. Available from: http://www.apa.org/topics/bipolar/index.aspx

Perito MES, Fortunato JJ. Marcadores Biológicos da Depressão: Uma Revisão Sobre a Expressão de Fatores Neurotróficos. Rev Neurocienc. 2012; 20(4):597-603

Levy B, Manove E. Functional Outcome in Bipolar Disorder: The Big Picture. Depression Research and Treatment. 2012; 12 pages

Thakker-Varia S, Alder J. Neuropeptides in depression: Role of VGF. Behavioural Brain Research. 2009; 197: 262–278

Del-Porto JA, Del-Porto KO. História da caracterização nosológica do transtorno bipolar. Rev. Psiq. Clín. 2005; 32: 7-14

Classificação Internacional De Doenças CID-10, O.M.D.S. 2008.

Almeida KM, Moreira CLRL, Lafer B. Metabolic Syndrome and Bipolar Disorder: What Should Psychiatrists Know?. CNS Neuroscience & Therapeutics. 2012;18:160–166

Proudfoot J, Doran J, Manicavasagar V, Parker G. The precipitants of manic/hypomanic episodes in the context of bipolardisorder: A review. Journal of Affective Disorders. 2011; 133:381–387

ABP: Associação Brasileira de Psiquiatria [acessado em 05.05.2013]. Available from: http://www.abp.org.br/portal/archive/12566

Equilibrium The Bipolar Foundation [acessado em 20.01.2013]. Available from:http://www.bipolar-foundation.org/bipolar-disorder/specific-populations/

Castelo M.S et al. Screening for bipolar disorder in the primary care: a Brazilian survey. J Affect Disord. 2012, 143: 118-24

Merikangas K, Jin R, Jian-Ping He, Kessler RC, Lee S, Sampson NA et al. Prevalence and Correlates of Bipolar Spectrum Disorder in the World Mental Health Survey Initiative. Arch Gen Psychiatry. 2011; 68: 241–251.

Barman SM. Introdução ao Sistema Nervoso. In: RAFF H, LEVITZKY M. Fisiologia Médica, uma aborgagem integrada. São Paulo: ARTMED. 2011; 105-115

Cunha C, Brambilla R,Thomas KL. A simple role for BDNF in learning and memory? Frontiers in Molecular Neuroscience. 2010; 3

Sebben AD, Cocolichio F, Schmitt APV, Curra MD, Silva PV, Tres GL et al. Efeito de fatores neurotróficos sobre o reparo de nervo periférico. Scientia Medica (Porto Alegre) 2011; 21:81-89

Fernandes BS, Gama CS, Ceresér KM, Yatham LN, Fries GR, Colpo G et al. Brain-derived neurotrophic factor as a state-marker of mood episodes in bipolar disorders: A systematic review and meta-regression analysis. Journal of Psychiatric Research. 2011; 995 e1004

Grande I, Fries GR, Kunz M, Kapczinski F. The Role of BDNF as a Mediator of Neuroplasticity in Bipolar Disorder. Psychiatry Investig 2010;7:243-250

Barbosa IG, Rocha NP, Huguet RB, Ferreira RA, Salgado JV, Carvalho LA et al. Executive dysfunction in euthymic bipolar disorder patients and its association with plasma biomarkers. Journal of Affective Disorders. 2012; 137:151–155

Barbosa IG,Rocha NP, Miranda AS, Huguet RB, Bauer ME,Reis HJ et al. Increased BDNF levels in long-term bipolar disorder patients. Rev Bras Psiquiatr. 013;35:067-069

Karege F, Bondolfi G, Gervasoni N, Schwald M, Aubry JM, Bertschy G. Low Brain-Derived Neurotrophic Factor (BDNF) Levels in Serum of Depressed Patients Probably Results from Lowered Platelet BDNF Release Unrelated to Platelet Reactivity. BIOL PSYCHIATRY 2005;57:1068–1072

Yuluga B, Ozan E, Gonulo AS, Kilic E. Brain-derived neurotrophic factor, stress and depression: A minireview. Brain Research Bulletin. 2009; 78: 267–269

Aan M, Mathew SJ, Charney DS. Neurobiological mechanisms in major depressive disorder. Cmaj. 2009 Feb; 180: 305-13

Kauer-Sant’Anna M, Kapczinski F, Andreazza AC, Bond DJ, Lam RW, Young T, Yatham LN. Brain-derived neurotrophic factor and inflammatory markers in patients with early- vs. late-stage bipolar disorder. International Journal of Neuropsychopharmacology. 2009; 12: 447–458.

Gama CS, Kunz M, Magalhães PVS, Kapczinski F. Staging and neuroprogression in bipolar disorder: a systematicreview of the literature. Rev Bras Psiquiatr. 2013;35:70-74

Magalhaes PV, Jansen K, Pinheiro RT, Klamt F, Teixeira AL, Da Silva RA et al. Systemic toxicity in early-stage mood disorders. J Psychiatr Res.2011;45:1407-9.

Magalhães PVS, Fries GR, Kapczinski F. Marcadores perifericos e a fisiopatologia do transtorno bipolar. Rev Psiq Clín. 2012;39:60-7

Tramontina JF, Andreazza AC, Kauer-Sant’Anna M, Stertz L, Goi J, Chiarani F et al. Brain-derived neurotrophic factor serum levels before and after treatment for acute mania. Neuroscience Letters. 2009; 452:111–113

Kenna GA, Roder-Hanna N, Leggio L, Zywiak WH, Clifford J, Edwards S et al. Association of the 5-HTT gene-linked promoter region (5-HTTLPR) polymorphism with psychiatric disorders: review of psychopathology and pharmacotherapy. Pharmacogenomics and Personalized Medicine. 2012; 5: 19–35

Michelon L, Vallada H. Genética do transtorno bipolar. Rev Bras Psiquiatr. 2004; 26:12-6

Andreazza AC, Young LT. The neurobiology of bipolar disorder: identifying targets for specific agents and synergies for combination treatment. International Journal of Neuropsychopharmacology. 2013; 1:14

Tramontina JF, Miranda DM, Filho HCS, Romano-Silva MA. Genética e transtorno bipolar. In: Kapczinski F, Quevedo J. Transtorno Bipolar e teórica clínica. São Paulo: ARTMED. 2009; 61-74

Egan MF, Kojima M, Callicott JH, Goldberg TE, Kolachana BS, Bertolino A et al. The BDNF val66met Polymorphism Affects Activity-Dependent Secretion of BDNF and Human Memory and Hippocampal Function. Cell. 2003 Jan; 112: 257–269

Teh CA, Lee TS, Kuchibhatla M, Ashley-Koch A, MacFall J, Krishnan R et al. Bipolar Disorder, Brain-Derived Neurotrophic Factor (BDNF) Val66Met Polymorphism and Brain Morphology. PLoS ONE. 2012; 7:38469

Mercedes Z´ R, Ricardo D´ V, Nieves B, Aurora A, Biotza G, Marı´a I. Z et al. Catechol O-methyltransferase and monoamine oxidase A genotypes, and plasma catecholamine metabolites in bipolar and schizophrenic patients. Neurochemistry International. 2010, 56:774–779

Virit O, Erdal ME, Savas HA, Barlas O, Yumru M, Gokdogan T et al. Catechol-O-methyltransferase gene Val108/158Met polymorphism in bipolar disorder. Neurology, Psychiatry and Brain Research. 2011; 1 7:4 6 –50

Nishioka AS, Perin EA, Sampaio AS, Cordeiro Q, Cappi C, Mastrorosa RS et al. O papel do polimorfismo funcional VNTR da regiao promotora do gene MAOA nos transtornos psiquiátricos. Rev Psiq Clín. 2011; 38:34-42

Caspi A, Hariri AR, Holmes A, Uher R, Moffitt TE. Genetic Sensitivity to the Environment: The Case of the Serotonin Transporter Gene and Its Implications for Studying Complex Diseases and Traits. Am J Psychiatry 2010; 167:509–527

Neves FS, Malloy-Diniz LF, Romano-Silva MA, Aguiar GC, Matos LO, Correa H. Is the serotonin transporter polymorphism (5-HTTLPR) a potential marker for suicidal behavior in bipolar disorder patients?. Journal of Affective Disorders. 2010; 125:98–102

Li D, He L. Meta-analysis supports association between serotonin transporter (5-HTT) and suicidal behavior. Molecular Psychiatry. 2007; 12:47–54

Hauser J, Leszczynska A, Samochowiec J, Czerski PM, Ostapowicz A, Chlopocka M et al. Association analysis of the insertion/deletion polymorphism in serotonin transporter gene in patients with affective disorder. Eur Psychiatry. 2003 May;18:129-32.

Rybakowski JK. Genetic Influences on Response to Mood Stabilizers in Bipolar Disorder. CNS Drugs. 2013; 27:165–173

Rybakowski JK, Suwalska A, Czerski PM, Dmitrzak-Weglarz M, Leszczynska-Rodziewicz A, Hauser J. Prophylactic effect of lithium in bipolar affective illness may be related to serotonin transporter genotype. Pharmacol Rep. 2005; 57:124-7

Dwivedi Y, Pandey GN. Adenylyl cyclase-cyclicAMP signaling in mood disorders: Role of the crucial phosphorylating enzyme protein kinase A. Neuropsychiatric Disease and Treatment 2008; 4:161–176

Mamdani F; Alda M; Grof P; Young LT, Rouleau G, Turecki G. Lithium Response and Genetic Variation in the CREB Family of Genes. Am J Med Genet B Neuropsychiatr Genet. 2008 June 5; 147B: 500–504.

McDonald ML, MacMullen C, Liu DJ, Leal SM, Davis RL.Genetic association of cyclic AMP signaling genes with bipolar disorder. Transl Psychiatry. 2012 ; 2;2:e169.