Effectiveness of therapeutic and pharmacological interventions in the treatment of cannabis dependence: a narrative review

Authors

  • Marcia Andrea da Silva Carvalho Sombra Especializanda, Associação de Psiquiatria Cyro Martins, CCYM, Porto Alegre, RS, Brasil https://orcid.org/0000-0003-0513-5337
  • Milton Armando Teresa Malai Moçambique Clínico e Investigador, Faculdade de Medicina, Ministério de Saúde, MISAU, Maputo, Moçambique https://orcid.org/0000-0002-5288-2207
  • Lucas Cavalcante Sombra Graduando, Psicologia, Universidade de Fortaleza, UNIFOR, Fortaleza, CE, Brasil https://orcid.org/0009-0008-8838-8201
  • Gabriel Antonio Roberto Especializando, Associação de Psiquiatria Cyro Martins, CCYM, Porto Alegre, RS, Brasil https://orcid.org/0000-0001-9814-9038
  • Renata Reis Frizon Especializando, Associação de Psiquiatria Cyro Martins, CCYM, Porto Alegre, Rio Grande do Sul, Brasil https://orcid.org/0000-0002-1856-2699
  • Aristone José Pacheco Marinho Especializando, Associação de Psiquiatria Cyro Martins, CCYM, Porto Alegre, RS, Brasil https://orcid.org/0000-0002-8747-5695
  • Isabella Scalabrini Ferrari Especializanda, Associação de Psiquiatria Cyro Martins, CCYM, Porto Alegre, RS, Brasil https://orcid.org/0000-0002-3200-5653
  • Pedro Eugênio Mazzucchi Santana Ferreira Médico Psiquiatra, Pontifícia Universidade Católica do Rio Grande do SUL, PUCRS, Porto Alegre, RS, Brasil https://orcid.org/0000-0003-4049-2604

DOI:

https://doi.org/10.25118/2763-9037.2024.v14.1301

Keywords:

cannabis use disorder, therapeutic approaches, pharmacotherapy, narrative review, marihuana

Abstract

This study reviewed therapeutic and pharmacological interventions for the treatment of Cannabis use disorder. Review studies that directly addressed therapeutic, pharmacological, or psychosocial interventions for cannabis dependence were included. The search identified 430 articles, of which 11 were included in the review. The results highlighted findings on pharmacotherapy, mixed interventions, psychotherapies, and digital treatments. We conclude that while there are promising interventions, such as behavioral therapies and digital programs, more rigorous research is needed to effectively address problematic cannabis use.

Downloads

Download data is not yet available.

Metrics

Metrics Loading ...

Author Biographies

Marcia Andrea da Silva Carvalho Sombra, Especializanda, Associação de Psiquiatria Cyro Martins, CCYM, Porto Alegre, RS, Brasil

Milton Armando Teresa Malai Moçambique, Clínico e Investigador, Faculdade de Medicina, Ministério de Saúde, MISAU, Maputo, Moçambique

Lucas Cavalcante Sombra, Graduando, Psicologia, Universidade de Fortaleza, UNIFOR, Fortaleza, CE, Brasil

Gabriel Antonio Roberto, Especializando, Associação de Psiquiatria Cyro Martins, CCYM, Porto Alegre, RS, Brasil

 

 

Renata Reis Frizon, Especializando, Associação de Psiquiatria Cyro Martins, CCYM, Porto Alegre, Rio Grande do Sul, Brasil

Aristone José Pacheco Marinho, Especializando, Associação de Psiquiatria Cyro Martins, CCYM, Porto Alegre, RS, Brasil

Isabella Scalabrini Ferrari, Especializanda, Associação de Psiquiatria Cyro Martins, CCYM, Porto Alegre, RS, Brasil

Pedro Eugênio Mazzucchi Santana Ferreira, Médico Psiquiatra, Pontifícia Universidade Católica do Rio Grande do SUL, PUCRS, Porto Alegre, RS, Brasil

References

Clarke R, Merlin M. Cannabis: evolution and ethnobotany. Oakland: University of California Press; 2016. http://www.jstor.org/stable/10.1525/j.ctt3fh2f8

Braithwaite I, Newton-Howes G, Oldfield K, Semprini A. Cannabis-based medicinal products and the role of the doctor: should we be cautious or cautiously optimistic? N Z Med J. 2019;132(1500):82–8.

Lima MCM, Valença MM, Machado CE, Melo Pereira ME, Brant PK. Uso da Cannabis medicinal e autismo. J Meml Med. 2020;2(1):5-14. https://doi.org/10.37085/jmmv2.n1.2020.pp.5-14 DOI: https://doi.org/10.37085/jmmv2.n1.2020.pp.5-14

Medeiros FC, Soares PB, Jesus RA, Teixeira DG, Alexandre MM, Sabec GZ. Uso medicinal da Cannabis sativa (Cannabaceae) como alternativa no tratamento da epilepsia. Braz J Dev. 2020;6(6):41510-23. https://doi.org/10.34117/bjdv6n6-623 DOI: https://doi.org/10.34117/bjdv6n6-623

Murnion B. Medicinal Cannabis. Aust Prescr. 2015;38(6).

https://doi.org/10.18773/austprescr.2015.072 - PMid:26843715 PMCid:PMC4674028 DOI: https://doi.org/10.18773/austprescr.2015.072

Britto LR, Araújo AN, Araújo RPC. Associações entre o uso de Cannabis e esquizofrenia: uma revisão da literatura. Rev. Ciênc. Med. Biol. 2016;15(1):95–102. https://doi.org/10.9771/cmbio.v15i1.16156 DOI: https://doi.org/10.9771/cmbio.v15i1.16156

Nascimento IC, Zocante A, Braide SM, Chaves FF, Oliveira Ferreira GL, Rezende LF. Relação entre Cannabis e psicose. Rev Universidade Vale Rio Verde. 2015;13(1):186-9.

https://doi.org/10.5892/ruvrd.v13i1.1946 DOI: https://doi.org/10.5892/ruvrd.v13i1.1946

Hall W. Getting to grips with the Cannabis problem: the evolving contributions and impact of Griffith Edwards. Addict Abingdon Engl. 2015; 110:36-9. https://doi.org/10.1111/add.12907 PMid:26042566 DOI: https://doi.org/10.1111/add.12907

Di Forti M, Marconi A, Carra E, Fraietta S, Trotta A, Bonomo M, Bianconi F, Gardner-Sood P, O'Connor J, Russo M, Stilo SA, Marques TR, Mondelli V, Dazzan P, Pariante C, David AS, Gaughran F, Atakan Z, Iyegbe C, Powell J, Morgan C, Lynskey M. Proportion of patients in south London with first-episode psychosis attributable to use of high potency Cannabis: a case-control study. Lancet Psychiatry. 2015;2(3):233-8. https://doi.org/10.1016/S2215-0366(14)00117-5 - PMid:26359901 DOI: https://doi.org/10.1016/S2215-0366(14)00117-5

Hasin DS, Sarvet AL, Cerdá M, Keyes KM, Stohl M, Galea S, Wall MM. US adult illicit Cannabis use, Cannabis use disorder, and medical marijuana laws: 1991-1992 to 2012-2013. JAMA Psychiatry. 2017;74(6):579-88. https://doi.org/10.1001/jamapsychiatry.2017.0724 DOI: https://doi.org/10.1001/jamapsychiatry.2017.0724

PMid:28445557 - PMCid:PMC5539836

Ribeiro GCA, Vieira W de A, Herval ÁM, Rodrigues RPCB, Agostini BA, Flores-Mir C, Repeke CEP, Paranhos LR. Prevalence of mental disorders among elderly men: a systematic review and meta-analysis. Sao Paulo Med J. 2020;138(3):190–200. https://doi.org/10.1590/1516-3180.2019.0454.R1.16012020 DOI: https://doi.org/10.1590/1516-3180.2019.0454.r1.16012020

Myers B, Petersen-Williams P, van der Westhuizen C, Lund C, Lombard C, Joska JA, Levitt NS, Butler C, Naledi T, Milligan P, Stein DJ, Sorsdah K. Community health worker-delivered counselling for common mental disorders among chronic disease patients in South Africa: a feasibility study. BMJ Open. 2019;9(1): e024277. https://doi.org/10.1136/bmjopen-2018-024277 PMid:30647043 PMCid:PMC6340481 DOI: https://doi.org/10.1136/bmjopen-2018-024277

Kondo K, Morasco BJ, Nugent S, Ayers C, O'Neil ME, Freeman M, Kansagara D. Pharmacotherapy for the treatment of Cannabis use disorder: a systematic review. Washington (DC): Department of Veterans Affairs (US); 2019. https://doi.org/10.7326/M19-1105 PMid:32120384 DOI: https://doi.org/10.7326/M19-1105

Sharma R, Tikka SK, Bhute AR, Bastia BK . N-acetyl cysteine in the treatment of Cannabis use disorder: a systematic review of clinical trials. Addict Behav. 2022;129:107283. DOI: https://doi.org/10.1016/j.addbeh.2022.107283

https://doi.org/ 10.1016/j.addbeh.2022.107283

Marshall K. Pharmacotherapies for Cannabis dependence. 2014 | Cochrane Library. Disponível em: https://www.cochranelibrary.com/cdsr/doi/10.1002/14651858 DOI: https://doi.org/10.1002/14651858.CD008940.pub2

Bahji A, Meyyappan AC, Hawken ER, Tibbo PG. Pharmacotherapies for Cannabis use disorder: a systematic review and network meta-analysis. Int J Drug Policy. 2021; 97:103295.

https://doi.org/10.1016/j.drugpo.2021.103295 - PMid:34062288 PMCid:PMC8881089 DOI: https://doi.org/10.1016/j.drugpo.2021.103295

Senderovich H, Patel P, Jimenez Lopez B, Waicus S. A systematic review on Cannabis hyperemesis syndrome and its management options. Med Princ Pract. 2022;31(1):29-38.

https://doi.org/10.1159/000520417 - PMid:34724666 PMCid:PMC8995641 DOI: https://doi.org/10.1159/000520417

Sabioni P, Le Foll B. Psychosocial and pharmacological interventions for the treatment of Cannabis use disorder. FOCUS. 2019;17(2):163-8.

https://doi.org/10.1176/appi.focus.17202 - PMid:32021586 PMCid:PMC6527000 DOI: https://doi.org/10.1176/appi.focus.17202

Olmos A, Tirado-Muñoz J, Farré M, Torrens M. The efficacy of computerized interventions to reduce Cannabis use: systematic review and meta-analysis. Addict Behav. 2018;79:52-60. https://doi.org/10.1016/j.addbeh.2017.11.045 - PMID:29248863 DOI: https://doi.org/10.1016/j.addbeh.2017.11.045

Nassif YB, Rahioui H, Varescon I. Psychological interventions for Cannabis use among adolescents and young adults: a systematic review. Int J Environ Res Public Health. 2023;20(14):6346. https://doi.org/10.3390/ijerph20146346 - PMID:37510578 PMCID:PMC:10380066 DOI: https://doi.org/10.3390/ijerph20146346

Walsh H, McNeill A, Purssell E, Duaso M. A systematic review and Bayesian meta-analysis of interventions which target or assess co-use of tobacco and Cannabis in single- or multi-substance interventions. Addiction. 2020;115(10):1800-14.

https://doi.org/10.1111/add.14993 - PMid:32003088 DOI: https://doi.org/10.1111/add.14993

Bonfiglio NS, Mascia ML, Cataudella S, Penna MP. Digital help for substance users (SU): a systematic review. Int J Environ Res Public Health. 2022;19(18):11309. https://doi.org/10.3390/ijerph19181130 DOI: https://doi.org/10.3390/ijerph191811309

Published

2024-09-22

How to Cite

1.
Sombra MA da SC, Moçambique MATM, Sombra LC, Roberto GA, Frizon RR, Marinho AJP, Ferrari IS, Ferreira PEMS. Effectiveness of therapeutic and pharmacological interventions in the treatment of cannabis dependence: a narrative review. Debates em Psiquiatria [Internet]. 2024 Sep. 22 [cited 2024 Oct. 18];14:1-19. Available from: https://revistardp.org.br/revista/article/view/1301

Issue

Section

Review Articles

Plaudit

Most read articles by the same author(s)