Psychiatric manifestations in rheumatology

Authors

DOI:

https://doi.org/10.25118/2763-9037.2022.v12.279

Keywords:

arthritis heumatoid, mental disorder, systemic lupus erythematosus

Abstract

The present literature review investigated symptoms related to Rheumatoid Arthritis and Systemic Lupus Erythematosus. We believe that a new paradigma must be established in psychiatry, considering that the relation between rheumatological diseases and psychiatric symptoms should be highlighted, helping to refine diagnosis and therapeutic proposals in mental health. Thus, we seek to trace evidence of psychiatric conditions prototypes that are more characteristically associated with the aforementioned rheumatological conditions. Symptoms related to mood disorders, mainly depression, were strongly associated with the higher incidence and morbidity in Rheumatoid Arthritis; besides, cognitive deficits, especially on moderate levels, are the most prevalent neuropsychiatric symptoms in Systemic Lupus Erythematosus. Pharmacological treatment of the underlying rheumatological disease is essential to improve the associated psychiatric condition, whether by direct or indirect influence of such condition. As for Lupus, current therapeutic strategies are largely empirical, carried out through known immunopathogenic mechanisms and results observed from treatment of severe manifestations in other organs. Regarding Rheumatoid Arthritis, the specific pharmacological treatment of the psychiatric condition is essential according to the individual demand of each patient, and intersubjectivity and the psychosomatic aspects should always be taken into consideration.

Downloads

Download data is not yet available.

Metrics

Metrics Loading ...

Author Biographies

Silvia Poliana Guedes Alcoforado Costa, Médica residente no Hospital das Clínicas da Universidade Federal de Pernambuco

Camila Farias Araujo , Médica residente no Hospital das Clínicas da Universidade Federal de Pernambuco

Taís Simplício Ramos, Graduanda do curso de Medicina da Universidade Federal de Pernambuco (UFPE)

Philip Azevedo Costa Urquiza, Médico Residente do Programa de Psiquiatria do Hospital das Clínicas de Pernambuco

Amaury Cantilino, Universidade Federal de Pernambuco

References

Isaac ML, Larson EB. Medical conditions with neuropsychiatric manifestations. Med Clin North Am [Internet]. 2014;98(5):1193-208. https://doi.org/10.1016/j.mcna.2014.06.012 - PMid:25134879 DOI: https://doi.org/10.1016/j.mcna.2014.06.012

Senna ER, Barros AL, Silva OE, Costa SE, Pereira LV, Ciconelli, RM, Ferraz MB. Prevalence of rheumatic diseases in Brazil: a study using the COPCORD approach. Journal of Rheumathology, v. 31, n. 3, 2004. p. 594-597. https://pubmed.ncbi.nlm.nih.gov/14994410/

Asano AMJ, Coriolano MGWS, Anano BJ, Lins OG. Comorbidades psiquiátricas em pacientes com lúpus eritematoso sistêmico: uma revisão sistemática dos últimos 10 anos. Rev. Bras. Reumatol. São Paulo , v. 53, n. 5, p. 431-437, Oct. 2013. https://doi.org/10.1590/S0482-50042013000500010 DOI: https://doi.org/10.1590/S0482-50042013000500010

Joaquim AF, Appenzeller S. Neuropsychiatric manifestations in rheumatoid arthritis. Autoimmun Rev [Internet]. 2015;14(12):1116-22. https://doi.org/10.1016/j.autrev.2015.07.015 - PMid:26238502 DOI: https://doi.org/10.1016/j.autrev.2015.07.015

Wang Q, Yang C, Gelernter J, Zhao H. Pervasive pleiotropy between psychiatric disorders and immune disorders revealed by integrative analysis of multiple GWAS. Hum Genet [Internet]. 2015 Nov 4 [cited 2019 Aug 25];134(11-12):1195-209.

https://doi.org/10.1007/s00439-015-1596-8 - PMid:26340901 PMCid:PMC4630076 DOI: https://doi.org/10.1007/s00439-015-1596-8

Hassan AA, Nasr MH, Mohamed AL, Kamal AM, Elmoghazy AD. Psychological affection in rheumatoid arthritis patients in relation to disease activity. Medicine (Baltimore) [Internet]. 2019 May [cited 2019 Jul 22];98(19):e15373. https://doi.org/10.1097/MD.0000000000015373 - PMid:31083165 PMCid:PMC6531278 DOI: https://doi.org/10.1097/MD.0000000000015373

Kim H-A, Jeon J-Y, Koh B-R, Park S-B, Suh C-H. Salivary cortisol levels, but not salivary α-amylase levels, are elevated in patients with rheumatoid arthritis irrespective of depression. Int J Rheum Dis [Internet]. 2016 Feb [cited 2019 Jul 22];19(2):172-7.

https://doi.org/10.1111/1756-185X.12224 - PMid:24237602 DOI: https://doi.org/10.1111/1756-185X.12224

Marrie RA, Hitchon CA, Walld R, Patten SB, Bolton JM, Sareen J, et al. Increased Burden of Psychiatric Disorders in Rheumatoid Arthritis. Arthritis Care Res (Hoboken) [Internet]. 2018 Jul [cited 2019 Aug 20];70(7):970-8. https://doi.org/10.1002/acr.23539 DOI: https://doi.org/10.1002/acr.23539

PMid:29438604 - PMCid:PMC6033023

Jump RL, Fifield J, Tennen H, Reisine S, Giuliano AJ. History of affective disorder and the experience of fatigue in rheumatoid arthritis. Arthritis Care Res (Hoboken) [Internet]. 2004 Apr 15 [cited 2019 Aug 20];51(2):239-45. https://doi.org/10.1002/art.20243 - PMid:15077266 DOI: https://doi.org/10.1002/art.20243

Matcham F, Davies R, Hotopf M, Hyrich KL, Norton S, Steer S, Galloway J. The relationship between depression and biologic treatment response in rheumatoid arthritis: An analysis of the British Society for Rheumatology Biologics Register. Rheumatol (United Kingdom) [Internet]. 2018 May 1 [cited 2019 Jul 22];57(5):835-43. https://doi.org/10.1093/rheumatology/kex528 - PMid:29447376 DOI: https://doi.org/10.1093/rheumatology/kex528

Gjevre JA, Taylor-Gjevre RM, Nair B V., Lim HJ. Do Sleepy Rheumatoid Arthritis Patients Have A Sleep Disorder? Musculoskeletal Care [Internet]. 2012 Dec [cited 2019 Aug 20];10(4):187-95. https://doi.org/10.1002/msc.1016 - PMid:22577060 DOI: https://doi.org/10.1002/msc.1016

Shin SY, Katz P, Wallhagen M, Julian L. Cognitive impairment in persons with rheumatoid arthritis. Arthritis Care Res (Hoboken) [Internet]. 2012 Aug [cited 2019 Aug 20];64(8):n/a-n/a.

https://doi.org/10.1002/acr.21683 - PMid:22505279 PMCid:PMC3744877 DOI: https://doi.org/10.1002/acr.21683

Kitamura E, Kondo Y, Kanazawa N, Akutsu T, Nishiyama K, Iizuka T. Autoimmune Encephalitis as an Extra-articular Manifestation of Rheumatoid Arthritis. Intern Med [Internet]. 2019 Apr 1 [cited 2019 Jul 22];58(7):1007-9. https://doi.org/10.2169/internalmedicine.1846-18 - PMid:30449780 - PMCid:PMC6478993 DOI: https://doi.org/10.2169/internalmedicine.1846-18

Sul A. Artigo Revisão artrite reumatoide inicial - conceitos. 2010;56(2):227-9. https://doi.org/10.1590/S0104-42302010000200024 - PMid:20499000 DOI: https://doi.org/10.1590/S0104-42302010000200024

Mota LMH, Cruz BA, Brenola CV, Pereira IA, Rezende-Fronza LS, Bertolo MB, Freitas MVC, Silva NA, Louzada-Junior P, Giorgio RDN, Lima RAC, Kairalla RA, Kawassaki AM, Bernardo WM, Castelar Pinheiro GRC. Guidelines for the diagnosis of rheumatoid arthritis. Rev Bras Reumatol [Internet]. 2013 [cited 2019 Sep 8];53(2):141-57. https://doi.org/10.1016/S2255-5021(13)70019-1 DOI: https://doi.org/10.1016/S2255-5021(13)70019-1

Aletaha D, Neogi T, Silman AJ, Funovits J, Felson DT, Bingham CO, Birnbaum, NS, Burmester, GR, Bykerk, VP, Cohen, MD, Combe, B, Costenbader, KH, Dougados, M, Emery, P, Ferraccioli, G, Hazes, JMW, Hobbs, K, Huizinga, TWJ, Kavanaugh, A, Kay, J, Kvien, TK, Laing, T, Mease, P, Ménard, HA, Moreland, LW, Naden, RL, Pincus, T, Smolen, JS, Stanislawska-Biernat, E, Symmons, D, Tak, PP, Upchurch, KS, Vencovský, J, Wolfe, F, Hawker, G. 2010 Rheumatoid arthritis classification criteria: An American College of Rheumatology/European League Against Rheumatism collaborative initiative. Arthritis Rheum [Internet]. 2010 Sep [cited 2019 Sep 8];62(9):2569-81.

https://doi.org/10.1002/art.27584 - PMid:20872595 DOI: https://doi.org/10.1002/art.27584

McGregor K, Bernatsky S, Colmegna I, Hudson M, Pastinen T, Labbe A, Greenwood CMT. An evaluation of methods correcting for cell-type heterogeneity in DNA methylation studies. Genome Biol [Internet]. 2016 May 3 [cited 2019 Jul 22];17(1):84.

https://doi.org/10.1186/s13059-016-0935-y - PMid:27142380 PMCid:PMC4855979 DOI: https://doi.org/10.1186/s13059-016-0935-y

Jiang HK, Chang DM. Non-steroidal anti-inflammatory drugs with adverse psychiatric reactions: Five case reports. Clin Rheumatol. 1999;18(4):339-45. https://doi.org/10.1007/s100670050114 - PMid:10468178 DOI: https://doi.org/10.1007/s100670050114

Alessi H, Dutra LA, Braga-Neto P, Pedroso JL, Toso FF, Kayser C, Barsottini OGP. Lúpus neuropsiquiátrico na prática clínica. Arq Neuropsiquiatr. 2016 Dec 1;74(12):1021-30. https://doi.org/10.1590/0004-282x20160150 - PMid:27992002 DOI: https://doi.org/10.1590/0004-282x20160150

Govoni M, Bortoluzzi A, Padovan M, Silvagni E, Borrelli M, Donelli F, Ceruti S, Trotta F. The diagnosis and clinical management of the neuropsychiatric manifestations of lupus. Vol. 74, Journal of Autoimmunity. Academic Press; 2016. p. 41-72.

https://doi.org/10.1016/j.jaut.2016.06.013 - PMid:27427403 DOI: https://doi.org/10.1016/j.jaut.2016.06.013

Vargas JV, Vaz CJ. Evaluation of central nervous system involvement in SLE patients. Screening psychiatric manifestations - a systematic review. Acta Reumatol Port. 2014;39(3):208-17.

Jeltsch-David H, Muller S. Neuropsychiatric systemic lupus erythematosus: Pathogenesis and biomarkers. Vol. 10, Nature Reviews Neurology. Nature Publishing Group; 2014. p. 579-96.

https://doi.org/10.1038/nrneurol.2014.148 - PMid:25201240 DOI: https://doi.org/10.1038/nrneurol.2014.148

Hajduk A, Nowicka-Sauer K, Smoleńska Z, Czuszyńska Z, Zdrojewski Z. Prevalence and correlates of suicidal thoughts in patients with neuropsychiatric lupus. Lupus. 2016;25(2):185-92.

https://doi.org/10.1177/0961203315603136 - PMid:26359173 DOI: https://doi.org/10.1177/0961203315603136

Cojocaru DC, Costin M, Bădeanu LE, Negru RD, Aursulesei V. Depression: a Fellow Traveler With Systemic Lupus Erythematosus. Rev Med Chir Soc Med Nat Iasi. 2015;119(4):974‐981.

Tang KT, Hsieh CW, Hsieh TY, Lan JL, Chen YH, Chen DY. Suicide Attempts in Patients With Systemic Lupus Erythematosus: A Single-Center Experience and Literature Review. Psychosomatics [Internet]. 2015;56(2):190-5. Available from:

https://doi.org/10.1016/j.psym.2014.05.020 - PMid:25627312 DOI: https://doi.org/10.1016/j.psym.2014.05.020

Hanly JG, Li Q, Su L, Urowitz MB, Gordon C, Bae SC, Romero-Diaz J, Sanchez-Guerrero J, Bernatsky S, Clarke AE, Wallace DJ, Isenberg DA, Rahman A, Merrill JT, Fortin PR, Gladman DD, Bruce IN, Petri M, Ginzler E, Dooley MA, Steinsson K, Ramsey-Goldman R, Zoma AA, Manzi S, Nived O, Jonsen A, Khamashta MA, Alarcón GS, van Vollenhoven RF, Aranow C, Mackay M, Ruiz-Irastorza G, Ramos-Casals M, Lim SS, Inanc M, Kalunian KC, Jacobsen S, Peschken CA, Kamen DL, Askanase A, Theriault C, Farewell V. Psychosis in Systemic Lupus Erythematosus: Results From an International Inception Cohort Study. Arthritis Rheumatol. 2019;71(2):281-9. https://doi.org/10.1002/art.40764 - PMid:30375754 - PMCid:PMC6353684 DOI: https://doi.org/10.1002/art.40764

Jafri K, Patterson SL, Lanata C. Central Nervous System Manifestations of Systemic Lupus Erythematosus. Vol. 43, Rheumatic Disease Clinics of North America. W.B. Saunders; 2017. p. 531-45. https://doi.org/10.1016/j.rdc.2017.06.003 - PMid:29061240 DOI: https://doi.org/10.1016/j.rdc.2017.06.003

Hanly JG. Diagnosis and management of neuropsychiatric SLE. Vol. 10, Nature Reviews Rheumatology. Nature Publishing Group; 2014. p. 338-47. https://doi.org/10.1038/nrrheum.2014.15 - PMid:24514913 DOI: https://doi.org/10.1038/nrrheum.2014.15

Kivity S, Baker B, Arango MT, Chapman J, Shoenfeld Y. Pharmacologic management of neuropsychiatric lupus. Vol. 9, Expert Review of Clinical Pharmacology. Taylor and Francis Ltd; 2016. p. 103-8. https://doi.org/10.1586/17512433.2016.1111137 - PMid:26559084 DOI: https://doi.org/10.1586/17512433.2016.1111137

Kamen DL, Zollars ES. Corticosteroids in Lupus Nephritis and Central Nervous System Lupus. Rheum Dis Clin North Am [Internet]. 2016;42(1):63-73. Available from: https://doi.org/10.1016/j.rdc.2015.08.008 - PMid:26611551 DOI: https://doi.org/10.1016/j.rdc.2015.08.008

Magro-Checa C, Zirkzee EJ, Huizinga TW, Steup-Beekman GM. Management of Neuropsychiatric Systemic Lupus Erythematosus: Current Approaches and Future Perspectives. Drugs. 2016;76(4):459-83. https://doi.org/10.1007/s40265-015-0534-3 - PMid:26809245 - PMCid:PMC4791452 DOI: https://doi.org/10.1007/s40265-015-0534-3

Published

2022-03-16

How to Cite

1.
Costa SPGA, Araujo CF, Ramos TS, Urquiza PAC, Cantilino A. Psychiatric manifestations in rheumatology. Debates em Psiquiatria [Internet]. 2022 Mar. 16 [cited 2024 Oct. 18];12:1-27. Available from: https://revistardp.org.br/revista/article/view/279

Issue

Section

Review Articles

Plaudit

Most read articles by the same author(s)

<< < 1 2 3 4 > >>