Tendencias emergentes en el tratamiento del trastorno obsesivo-compulsivo: una revisión de la literatura

Autores/as

DOI:

https://doi.org/10.25118/2763-9037.2024.v14.1309

Palabras clave:

trastorno obsesivo-compulsivo, TOC, terapia cognitivo-conductual, farmacoterapia, neuromodulación, intervenciones digitales, investigación genética, terapias integrativas, TOC pediátrico

Resumen

El trastorno obsesivo-compulsivo (TOC) es una afección de salud mental crónica y debilitante caracterizada por pensamientos persistentes e intrusivos y comportamientos repetitivos. Los tratamientos tradicionales, incluida la terapia cognitivo-conductual (TCC) y la farmacoterapia, han demostrado eficacia, pero a menudo están limitados por una respuesta parcial y altas tasas de recaída. Esta revisión de la literatura examina las tendencias emergentes en el tratamiento del TOC, destacando los avances en psicoterapia, nuevos agentes farmacológicos, técnicas de neuromodulación, intervenciones digitales, investigación genética y de biomarcadores, y terapias integrativas. Además, explora enfoques personalizados para poblaciones pediátricas y analiza las direcciones y desafíos futuros en este campo. La revisión subraya el potencial de estos tratamientos innovadores para mejorar los resultados terapéuticos y mejorar la calidad de vida de las personas con TOC.

Descargas

Los datos de descargas todavía no están disponibles.

Métricas

Cargando métricas ...

Biografía del autor/a

Kirolos Eskandar, Physician, Diakonie Klinik Mosbach, Mosbach, Germany

Citas

American Psychiatric Association. Diagnostic and statistical manual of mental disorders: DSM-5. 5th ed. Washington: American Psychiatric Association; 2013. https://doi.org/10.1176/appi.books.9780890425596 DOI: https://doi.org/10.1176/appi.books.9780890425596

National Institute of Mental Health. Obsessive-Compulsive Disorder (OCD). Bethesda: National Institute of Mental Health; [cited 2007 Feb 23]. https://www.nimh.nih.gov/health/statistics/obsessive-compulsive-disorder-ocd

Ruscio AM, Stein DJ, Chiu WT, Kessler RC. The epidemiology of obsessive-compulsive disorder in the National Comorbidity Survey Replication. Mol Psychiatry. 2010;15(1):53-63. https://doi.org/10.1038/mp.2008.94 PMID:18725912 - PMCID:PMC2797569 DOI: https://doi.org/10.1038/mp.2008.94

Veale D, Roberts A. Obsessive-compulsive disorder. BMJ. 2014;348:g2183. https://doi.org/10.1136/bmj.g2183 PMID:24709802 DOI: https://doi.org/10.1136/bmj.g2183

Phillips KA, Stein DJ. Obsessive-Compulsive Disorder (OCD). [place unknown]: MSD Manual Professional Version; 2023. https://www.msdmanuals.com/professional/psychiatric-disorders/obsessive-compulsive-and-related-disorders/obsessive-compulsive-disorder-ocd

Burkle JJ, Fendel JC, Schmidt S. Mindfulness-based and acceptance-based programmes in the treatment of obsessive-compulsive disorder: a study protocol for a systematic review and meta-analysis. BMJ Open. 2021;11(6):e050329. https://doi.org/10.1136/bmjopen-2021-050329 PMID:34172553 - PMCID:PMC8237723 DOI: https://doi.org/10.1136/bmjopen-2021-050329

International OCD Foundation. Transcranial Magnetic Stimulation (TMS) for OCD. Boston: International OCD Foundation; c2024. https://iocdf.org/about-ocd/treatment/tms/

Kelly, O. OCD medications: how antidepressants and antipsychotics can help. New York: Verywell Mind; 2024. https://www.verywellmind.com/medications-to-treat-ocd-2510644

Del Casale A, Sorice S, Padovano A, Simmaco M, Ferracuti S, Lamis DA, Rapinesi C, Sani G, Girardi P, Kotzalidis GD, Pompili M. Psychopharmacological treatment of obsessive-compulsive disorder (OCD). Curr Neuropharmacol. 2019;17(8):710-36. https://doi.org/10.2174/1570159x16666180813155017 PMID:30101713 - PMCID:PMC7059159. DOI: https://doi.org/10.2174/1570159X16666180813155017

Finch R, Vargas BE. We tried 100+ therapy services and apps-and we recommend these 8 for online CBT. New York: Verywell Mind; 2024. https://www.verywellmind.com/online-cbt-therapy-7371586

Akhouri D, Hamza, Kumar S, Reyazuddin M. Acceptance and commitment therapy as an add-on treatment for the management of patients with obsessive-compulsive disorder. Ind Psychiatry J. 2023;32(Suppl 1):S179-85. https://doi.org/10.4103/ipj.ipj_213_23 PMID:38370965 - PMCID:PMC10871435 DOI: https://doi.org/10.4103/ipj.ipj_213_23

Olivine A. What is mindfulness therapy? Mindfulness-based cognitive behavioral therapy and cognitive therapy, MBCBT, MBCT. New York: Verywell Health; 2024. https://www.verywellhealth.com/mindfulness-therapy-5212796

Bommarito S, Morris M. The role of antipsychotics in OCD. Silver Spring: Anxiety and Depression Association of America; 2023. https://adaa.org/learn-from-us/from-the-experts/blog-posts/professional/role-antipsychotics-ocd

Huang Y, Weng Y, Lan L, Zhu C, Shen T, Tang W, Lai HY. Insight in obsessive-compulsive disorder: conception, clinical characteristics, neuroimaging, and treatment. Psychoradiology. 2023;3:kkad025. https://doi.org/10.1093/psyrad/kkad025 PMID:38666121 - PMCID:PMC10917385 DOI: https://doi.org/10.1093/psyrad/kkad025

Garakani A, Freire RC, Buono FD, Thom RP, Larkin K, Funaro MC, Salehi M, Perez-Rodriguez MM. An umbrella review on the use of antipsychotics in anxiety disorders: a registered report protocol. PLoS One. 2022;17(6):e0269772. https://doi.org/10.1371/journal.pone.0269772 PMID:35709149 PMCID:PMC9202921 DOI: https://doi.org/10.1371/journal.pone.0269772

Food and Drug Administration. FDA permits marketing of transcranial magnetic stimulation for treatment of obsessive compulsive disorder. Silver Spring: Food and Drug Administration; 2018. https://www.fda.gov/news-events/press-announcements/fda-permits-marketing-transcranial-magnetic-stimulation-treatment-obsessive-compulsive-disorder

Tendler A, Blackman S. Achieving OCD relief: consideration of TMS earlier in the treatment continuum. Cranbury: Psychiatric Times; 2023. https://www.psychiatrictimes.com/view/achieving-ocd-relief-consideration-of-tms-earlier-in-the-treatment-continuum

Karas PJ, Lee S, Jimenez-Shahed J, Goodman WK, Viswanathan A, Sheth SA. Deep brain stimulation for obsessive compulsive disorder: evolution of surgical stimulation target parallels changing model of dysfunctional brain circuits. Front Neurosci. 2019;12:998. https://doi.org/10.3389/fnins.2018.00998 PMID:30670945 - PMCID:PMC6331476 DOI: https://doi.org/10.3389/fnins.2018.00998

Groves DA, Brown VJ. Vagal nerve stimulation: a review of its applications and potential mechanisms that mediate its clinical effects. Neurosci Biobehav Rev. 2005;29(3):493-500. https://doi.org/10.1016/j.neubiorev.2005.01.004 PMID:15820552 DOI: https://doi.org/10.1016/j.neubiorev.2005.01.004

Aspvall K, Andersson E, Melin K, Norlin L, Eriksson V, Vigerland S, Jolstedt M, Silverberg-Morse M, Wallin L, Sampaio F, Feldman I, Bottai M, Lenhard F, Mataix-Cols D, Serlachius E. Effect of an internet-delivered stepped-care program vs in-person cognitive behavioral therapy on obsessive-compulsive disorder symptoms in children and adolescents: a randomized clinical trial. JAMA. 2021;325(18):1863-73. https://doi.org/10.1001/jama.2021.3839 PMID:33974020 - PMCID:PMC8114140 DOI: https://doi.org/10.1001/jama.2021.3839

McGrath P. Can exercise help with OCD? Chicago: NOCD; 2021. https://www.treatmyocd.com/blog/can-exercise-help-with-ocd

Hedman E, Furmark T, Carlbring P, Ljotsson B, Ruck C, Lindefors N, Andersson G. A 5-Year follow-up of internet-based cognitive behavior therapy for social anxiety disorder. J Med Internet Res. 2011;13(2):e39. https://doi.org/10.2196/jmir.1776 PMID:21676694 - PMCID:PMC3221374 DOI: https://doi.org/10.2196/jmir.1776

Stein DJ, Costa DLC, Lochner C, Miguel EC, Reddy YCJ, Shavitt RG, van den Heuvel OA, Simpson HB. Obsessive-compulsive disorder. Nat Rev Dis Primers. 2019;5(1):52. https://doi.org/10.1038/s41572-019-0102-3 PMID:31371720 PMCID:PMC7370844 DOI: https://doi.org/10.1038/s41572-019-0102-3

Mahjani B, Bey K, Boberg J, Burton C. Genetics of obsessive-compulsive disorder. Psychol Med. 2021;51(13):2247-59. https://doi.org/10.1017/s0033291721001744 PMID:34030745 PMCID:PMC8477226 DOI: https://doi.org/10.1017/S0033291721001744

Pauls DL, Abramovitch A, Rauch SL, Geller DA. Obsessive-compulsive disorder: an integrative genetic and neurobiological perspective. Nat Rev Neurosci. 2014;15(6):410-24. https://doi.org/10.1038/nrn3746 PMID:24840803 DOI: https://doi.org/10.1038/nrn3746

Jiang C, Zou J, Lv Q, Yang Y. Systematic review and meta-analysis of the efficacy of N-acetylcysteine in the treatment of acute exacerbation of chronic obstructive pulmonary disease. Ann Palliat Med. 2021;10(6):6564-76. https://doi.org/10.21037/apm-21-1138 PMID:34237968 DOI: https://doi.org/10.21037/apm-21-1138

Fux M, Levine J, Aviv A, Belmaker RH. Inositol treatment of obsessive-compulsive disorder. Am J Psychiatry. 1996;153(9):1219-21. https://doi.org/10.1176/ajp.153.9.1219 PMID:8780431 DOI: https://doi.org/10.1176/ajp.153.9.1219

Katz DE, Rector NA, McCabe RE, Hawley LL, Rowa K, Richter MA, Ornstein T, Regev R, McKinnon M, Laposa JM. The effect of aerobic exercise alone and in combination with cognitive behavioural therapy on obsessive compulsive disorder: a randomized control study. J Anxiety Disord. 2023;98:102746. https://doi.org/10.1016/j.janxdis.2023.102746 PMID:37494756 DOI: https://doi.org/10.1016/j.janxdis.2023.102746

Didonna F, Lanfredi M, Xodo E, Ferrari C, Rossi R, Pedrini L. Mindfulness-based cognitive therapy for obsessive-compulsive disorder: a pilot study. J Psychiatr Pract. 2019;25(2):156-70. https://doi.org/10.1097/pra.0000000000000377 PMID:30849066 DOI: https://doi.org/10.1097/PRA.0000000000000377

Cervin M. [Podcast] Which Treatments Work for Pediatric OCD? Efficacy and Acceptability of CBT and Serotonin Reuptake Inhibitors. London: ACAMH; 2024. [33 min., 56 sec]. https://www.acamh.org/podcasts/which-treatments-work-for-pediatric-ocd/

Peris TS, Thamrin H, Rozenman MS. Family intervention for child and adolescent anxiety: a meta-analytic review of therapy targets, techniques, and outcomes. J Affect Disord. 2021;286:282-95. https://doi.org/10.1016/j.jad.2021.02.053 PMID:33756306 DOI: https://doi.org/10.1016/j.jad.2021.02.053

Angelosante A, Colognori D, Goldstein CR, Warner CM. School-based interventions for anxiety in youth. In: McKay D, Storch E, editors. Handbook of child and adolescent anxiety disorders. New York: Springer; 2011. https://doi.org/10.1007/978-1-4419-7784-7_28 DOI: https://doi.org/10.1007/978-1-4419-7784-7_28

Fineberg NA, Hollander E, Pallanti S, Walitza S, Grunblatt E, Dell'Osso BM, Albert U, Geller DA, Brakoulias V, Janardhan Reddy YC, Arumugham SS, Shavitt RG, Drummond L, Grancini B, De Carlo V, Cinosi E, Chamberlain SR, Ioannidis K, Rodriguez CI, Garg K, Castle D, Van Ameringen M, Stein DJ, Carmi L, Zohar J, Menchon JM. Clinical advances in obsessive-compulsive disorder: a position statement by the International College of Obsessive-Compulsive Spectrum Disorders. Int Clin Psychopharmacol. 2020;35(4):173-93. https://doi.org/10.1097/yic.0000000000000314 PMID:32433254 PMCID:PMC7255490 DOI: https://doi.org/10.1097/YIC.0000000000000314

Hirschtritt ME, Bloch MH, Mathews CA. Obsessive-compulsive disorder: advances in diagnosis and treatment. JAMA. 2017;317(13):1358-67. https://doi.org/10.1001/jama.2017.2200 PMID:28384832 DOI: https://doi.org/10.1001/jama.2017.2200

Simpson HB, Rynn MA. OCD: current research and future directions. Cranbury: Psychiatric Times; 2015. https://www.psychiatrictimes.com/view/ocd-current-research-and-future-directions

Ioannidis K, Chamberlain SR, Treder MS, Kiraly F, Leppink EW, Redden SA, Stein DJ, Lochner C, Grant JE. Problematic internet use (PIU): associations with the impulsive-compulsive spectrum. An application of machine learning in psychiatry. J Psychiatr Res. 2016;83:94-102. https://doi.org/10.1016/j.jpsychires.2016.08.010 PMID:27580487 - PMCID:PMC5119576 DOI: https://doi.org/10.1016/j.jpsychires.2016.08.010

Hollander E, Stein DJ, Fineberg NA, Marteau F, Legault M. Quality of life outcomes in patients with obsessive-compulsive disorder: relationship to treatment response and symptom relapse. J Clin Psychiatry. 2010;71(6):784-92. https://doi.org/10.4088/jcp.09m05911blu PMID:20492845 DOI: https://doi.org/10.4088/JCP.09m05911blu

Publicado

2024-08-22

Cómo citar

1.
Eskandar K. Tendencias emergentes en el tratamiento del trastorno obsesivo-compulsivo: una revisión de la literatura. Debates em Psiquiatria [Internet]. 22 de agosto de 2024 [citado 22 de diciembre de 2024];14:1-19. Disponible en: https://revistardp.org.br/revista/article/view/1309

Número

Sección

Artículo de revisión

Plaudit