The use of clozapine and other antipsychotics for treatment-resistant schizophrenia at the brazilian psychosocial care centers in Joao Pessoa, PB, Brazil
DOI:
https://doi.org/10.25118/2763-9037.2023.v13.511Keywords:
resistant schizophrenia, clozapine, antipsychoticsAbstract
Introduction: Although Clozapine is the drug recommended for treatment-resistant schizophrenia (TRS), it is underprescribed. Objectives: To analyze the pattern of clozapine prescription and use of other antipsychotics for patients with treatment-resistant schizophrenia in community mental health centers in Joao Pessoa. Methods: Antipsychotic prescriptions and medical records of patients with schizophrenia were reviewed. The psychiatrists of the services completed a survey on the difficulties associated with prescribing clozapine. Results: Among 381 patients with schizophrenia, 102 (26.8%) met the TRS criteria. Forty of the TRS patients (39.2%) were in polypharmacy; 25 in atypical antipsychotic monotherapy (24.6%), 3 with typical antipsychotic monotherapy (3%), and only 34 were using clozapine (33.3%). An important obstacle is the logistics required for blood counts routine. Conclusion: The most TRS patients (66.7%) was prescribed non-clozapine treatment, mostly polypharmacy, at the Brazilian Psychosocial Care Centers in Joao Pessoa.
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