Modelo animal de mania induzido por anfetamina como método de identificação de novos alvos terapêuticos para o transtorno bipolar
DOI:
https://doi.org/10.25118/2763-9037.2014.v4.259Palavras-chave:
Transtorno bipolar, fisiopatologia, TerapêuticaResumo
O Transtorno Bipolar é um transtorno do humor grave com grande morbidade e mortalidade. É caracterizado por recorrentes episódios de mania e depressão. Pouco se sabe sobre a precisa neurobiologia do TB, que é essencial para o desenvolvimento de terapias específicas que funcionem rapidamente e sejam mais eficazes e toleráveis que as terapias existentes. Dadas as limitações das tecnologias não invasivas atuais para estudar o cérebro humano, os modelos animais de transtornos psiquiátricos são uma das ferramentas mais importantes para os estudos neurobiológicos. Nessa revisão são abordados alguns novos alvos terapêuticos para o tratamento do transtorno bipolar, descobertos através de estudo com modelos animais. Estudos com o modelo animal de mania induzido por anfetamina apresentam excelentes resultados apontando o envolvimento do estresse oxidativo, da Proteína Quinase C e das Histonas Deacetilases na fisiopatologia do transtorno bipolar, assim como seu potencial enquanto alvos terapêuticos, porém, esses alvos devem ser continuamente explorados nos transtornos de humor.
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Copyright (c) 2014 Roger Bitencourt Varela, Wilson Rodrigues Resende , João Quevedo
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