Animal model of mania induced by amphetamine as a method of identification of new therapeutic targets for bipolar disorder
DOI:
https://doi.org/10.25118/2763-9037.2014.v4.259Keywords:
Bipolar disorder, Pathophysiology, TherapeuticsAbstract
Bipolar disorder is a severe mood disorder with high morbidity and mortality. Is characterized by recurrent manic and depressive episodes. Little is known about the precise neurobiology of TB, that is essential to the development of specifics therapies that work quickly and be more effective and better tolerable than existing therapies. Given the limitations of actual noninvasive technologies to study the human brain, the animal models of psychiatric disorders are one of the most relevant tools to neurobiological studies. This review focuses in some new therapeutic targets to the treatment of bipolar disorder, discovered through the animal model studies. Studies with animal model of mania induced by amphetamine shows excellent results indicating the involvement os oxidative stress, Protein Kinase C and histones deacetylase on bipolar pathophysiology, as its potential as therapeutics targets, however, these targets should be continuously explored on mood disorders
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