Evaluation of intestinal microbiota and use of probiotics in Alzheimer's disease
DOI:
https://doi.org/10.25118/2763-9037.2024.v14.1346Keywords:
Alzheimer disease, intestinal microbiota, probiotics, gastrointestinal microbiomeAbstract
Introduction: Alzheimer's disease is a disease resulting from a neurodegenerative process that is manifested by cognitive losses, particularly episodic memory and learning. As it is a neurocognitive disorder that affects memory, thinking and behavior, it is the most common cause of dementia and has a significant impact on daily activities, with high morbidity and mortality. The gut microbiota plays an important role in regulating brain functions and behavior, through the microbiota-gut-brain axis. Several studies have demonstrated a correlation between dysregulation of the intestinal microbiota and neurodegenerative diseases. Objective: To describe and analyze the involvement of the intestinal microbiota and the relationship of probiotics in Alzheimer's disease. Methodology: An integrative review of the literature was carried out and articles published in journals indexed in the Scientific Electronic Library Online (SCIELO), National Library of Medicine/NLM (MEDLINE) and National Library of Medicine/NLM (PUBMED) databases were selected. Results: The studies evaluated demonstrated a positive relationship between the intestinal microbiota in the development or progression of Alzheimer's disease and although there are few clinical trials evaluating the effect of probiotic consumption in humans with Alzheimer's disease, the results found so far indicate that supplementation with probiotics has a contribution beneficial effects, such as a reduction in the inflammatory process and the progression of the disease in question. Conclusion: The intestinal microbiota can be influenced by probiotics in patients with Alzheimer's disease, bringing cognitive and behavioral improvements, thus improving the quality of life of these patients.
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