Evaluation of intestinal microbiota and use of probiotics in Alzheimer's disease

Authors

  • Janaína Carla Parizotto da Rosa Especializanda, Psiquiatria, Hospital Vida, HV, Londrina, PR, Brasil https://orcid.org/0009-0006-8645-2340
  • Isadora Goldbaum Calil Lopes Especializanda, Psiquiatria, Hospital Vida, HV, Londrina, PR, Brasil https://orcid.org/0009-0006-0487-9413
  • Amanda Letícia Rainieri Especializanda, Psiquiatria, Hospital Vida, HV, Londrina, PR, Brasil https://orcid.org/0009-0006-5369-1193
  • Renato Daniel Ramalho Cardoso Doutor, Patologia Experimental, Universidade Estadual de Londrina, UEL, Londrina, PR, Brasil https://orcid.org/0000-0001-8193-8137
  • Paula Souza Lage Doutora, Programa de Pós-Graduação em Ciências da Saúde, Infectologia e Medicina Tropical, Faculdade de Medicina, Universidade Federal de Minas Gerais, UFMG, Belo Horizonte, MG, Brasil https://orcid.org/0000-0002-2744-3253

DOI:

https://doi.org/10.25118/2763-9037.2024.v14.1346

Keywords:

Alzheimer disease, intestinal microbiota, probiotics, gastrointestinal microbiome

Abstract

Introduction: Alzheimer's disease is a disease resulting from a neurodegenerative process that is manifested by cognitive losses, particularly episodic memory and learning. As it is a neurocognitive disorder that affects memory, thinking and behavior, it is the most common cause of dementia and has a significant impact on daily activities, with high morbidity and mortality. The gut microbiota plays an important role in regulating brain functions and behavior, through the microbiota-gut-brain axis. Several studies have demonstrated a correlation between dysregulation of the intestinal microbiota and neurodegenerative diseases.  Objective: To describe and analyze the involvement of the intestinal microbiota and the relationship of probiotics in Alzheimer's disease. Methodology: An integrative review of the literature was carried out and articles published in journals indexed in the Scientific Electronic Library Online (SCIELO), National Library of Medicine/NLM (MEDLINE) and National Library of Medicine/NLM (PUBMED) databases were selected. Results: The studies evaluated demonstrated a positive relationship between the intestinal microbiota in the development or progression of Alzheimer's disease and although there are few clinical trials evaluating the effect of probiotic consumption in humans with Alzheimer's disease, the results found so far indicate that supplementation with probiotics has a contribution beneficial effects, such as a reduction in the inflammatory process and the progression of the disease in question. Conclusion: The intestinal microbiota can be influenced by probiotics in patients with Alzheimer's disease, bringing cognitive and behavioral improvements, thus improving the quality of life of these patients.  

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Author Biographies

Janaína Carla Parizotto da Rosa, Especializanda, Psiquiatria, Hospital Vida, HV, Londrina, PR, Brasil

Studying in Psychiatry at Hospital Vida de Londrina - Class 2022-2025Postgraduate latu sensu in Psychiatry at the Medical and Surgical Clinic at Faculdade Israelita de Ciências da Saúde Albert Einstein in 2021.Graduate in Medicine from the Pontifical Catholic University of Paraná - Campus Londrina in 2018 . Degree in Business Administration from the Pontifical Catholic University of Paraná - Londrina Campus in 2011.

Isadora Goldbaum Calil Lopes, Especializanda, Psiquiatria, Hospital Vida, HV, Londrina, PR, Brasil

Graduated in Medicine from the University of Marília (2021).

Amanda Letícia Rainieri, Especializanda, Psiquiatria, Hospital Vida, HV, Londrina, PR, Brasil

Graduated in Medicine from the University of Mogi das Cruzes (2019). He is currently undergoing a training program in Psychiatry at Hospital Vida, in Londrina/PR, since February 2022, expected to be completed in February 2025.

Renato Daniel Ramalho Cardoso, Doutor, Patologia Experimental, Universidade Estadual de Londrina, UEL, Londrina, PR, Brasil

PhD from the Postgraduate Program in Experimental Pathology at the State University of Londrina - UEL; Master's degree from the Postgraduate Program in Experimental Pathology at the State University of Londrina - UEL. Postgraduate specialist in Psychiatry and Mental Health from the Brazilian School of Medicine; Postgraduate specialist in Public Health Management from Faculdade UNINA; Postgraduate specialist in Family Health from Faculdade UNINA; Graduated in Medicine from the Pontifical Catholic University of Paraná (PUCPR) - Londrina Campus

Paula Souza Lage, Doutora, Programa de Pós-Graduação em Ciências da Saúde, Infectologia e Medicina Tropical, Faculdade de Medicina, Universidade Federal de Minas Gerais, UFMG, Belo Horizonte, MG, Brasil

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Published

2024-12-31

How to Cite

1.
Rosa JCP da, Lopes IGC, Rainieri AL, Cardoso RDR, Lage PS. Evaluation of intestinal microbiota and use of probiotics in Alzheimer’s disease. Debates em Psiquiatria [Internet]. 2024 Dec. 31 [cited 2025 Feb. 5];14:1-20. Available from: https://revistardp.org.br/revista/article/view/1346

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